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Rationally designed ruthenium complexes for 1- and 2-photon photodynamic therapy

Author

Listed:
  • Johannes Karges

    (PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Laboratory for Inorganic Chemical Biology)

  • Shi Kuang

    (Sun Yat-sen University)

  • Federica Maschietto

    (PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Theoretical Chemistry and Modelling)

  • Olivier Blacque

    (University of Zurich)

  • Ilaria Ciofini

    (PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Theoretical Chemistry and Modelling)

  • Hui Chao

    (Sun Yat-sen University)

  • Gilles Gasser

    (PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Laboratory for Inorganic Chemical Biology)

Abstract

The use of photodynamic therapy (PDT) against cancer has received increasing attention over recent years. However, the application of the currently approved photosensitizers (PSs) is limited by their poor aqueous solubility, aggregation, photobleaching and slow clearance from the body. To overcome these limitations, there is a need for the development of new classes of PSs with ruthenium(II) polypyridine complexes currently gaining momentum. However, these compounds generally lack significant absorption in the biological spectral window, limiting their application to treat deep-seated or large tumors. To overcome this drawback, ruthenium(II) polypyridine complexes designed in silico with (E,E′)-4,4′-bisstyryl-2,2′-bipyridine ligands show impressive 1- and 2-Photon absorption up to a magnitude higher than the ones published so far. While nontoxic in the dark, these compounds are phototoxic in various 2D monolayer cells, 3D multicellular tumor spheroids and are able to eradicate a multiresistant tumor inside a mouse model upon clinically relevant 1-Photon and 2-Photon excitation.

Suggested Citation

  • Johannes Karges & Shi Kuang & Federica Maschietto & Olivier Blacque & Ilaria Ciofini & Hui Chao & Gilles Gasser, 2020. "Rationally designed ruthenium complexes for 1- and 2-photon photodynamic therapy," Nature Communications, Nature, vol. 11(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-16993-0
    DOI: 10.1038/s41467-020-16993-0
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    Cited by:

    1. Nong Lu & Zhihong Deng & Jing Gao & Chao Liang & Haiping Xia & Pingyu Zhang, 2022. "An osmium-peroxo complex for photoactive therapy of hypoxic tumors," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    2. Yuling Xu & Chonglu Li & Shuai Lu & Zhizheng Wang & Shuang Liu & Xiujun Yu & Xiaopeng Li & Yao Sun, 2022. "Construction of emissive ruthenium(II) metallacycle over 1000 nm wavelength for in vivo biomedical applications," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    3. Na Feng & Zhen Peng & Xin Zhang & Yiling Lin & Lianrui Hu & Lei Zheng & Ben Zhong Tang & Jing Zhang, 2024. "Strategically engineered Au(I) complexes for orchestrated tumor eradication via chemo-phototherapy and induced immunogenic cell death," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    4. Guanqun Han & Guodong Li & Jie Huang & Chuang Han & Claudia Turro & Yujie Sun, 2022. "Two-photon-absorbing ruthenium complexes enable near infrared light-driven photocatalysis," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    5. Gang Xu & Chengwei Li & Chen Chi & Luyan Wu & Yanyan Sun & Jian Zhao & Xing-Hua Xia & Shaohua Gou, 2022. "A supramolecular photosensitizer derived from an Arene-Ru(II) complex self-assembly for NIR activated photodynamic and photothermal therapy," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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