IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v20y2023i4p2803-d1058196.html
   My bibliography  Save this article

Effect of Fine Particulate Matter Exposure on Liver Enzymes: A Systematic Review and Meta-Analysis

Author

Listed:
  • Ling Pan

    (Research Institute for Environment and Health, Nanjing University of Information Science and Technology, Nanjing 210044, China)

  • Jing Sui

    (Research Institute for Environment and Health, Nanjing University of Information Science and Technology, Nanjing 210044, China
    Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China)

  • Ying Xu

    (Research Institute for Environment and Health, Nanjing University of Information Science and Technology, Nanjing 210044, China)

  • Qun Zhao

    (Research Institute for Environment and Health, Nanjing University of Information Science and Technology, Nanjing 210044, China)

  • Yinyin Cai

    (Institute of Atmospheric Environmental Economics, Nanjing University of Information Science and Technology, Nanjing 210044, China)

  • Guiju Sun

    (Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China)

  • Hui Xia

    (Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China)

Abstract

Although previous studies have presented that fine particulate matter (PM2.5) regulates liver enzyme levels in the development of liver diseases, the evidence regarding the relationship between PM2.5 exposure and liver enzyme is not robust. We further aimed to conduct a systematic review and meta-analysis of observational studies to summarize the recent evidence on the effects of PM2.5 on liver enzyme in humans. In the meta-analysis, we retrieved online databases including PubMed and Web of Science database from 1982 up to 2022. A random-effects model was applied to evaluate the correlation between PM2.5 and liver enzyme level. A total of 10 studies fulfilled the inclusion criteria, including five prospective cohort studies, two cross-sectional studies, two longitudinal studies, and one time-series analysis. Each 10 μg/m 3 increase in PM2.5 concentration was significantly correlated with a 4.45% increase in alanine aminotransferase (ALT) level (95% CI: 0.51–8.38%, p = 0.03), a 3.99% increase in aspartate transferase (AST) level (95% CI: 0.88–7.10%, p = 0.01), and a 2.91% increase in gamma-glutamyl transferase (GGT) level (95% CI: 1.18–4.64%, p < 0.001), but this significant association was not observed in alkaline phosphatase (ALP). Subgroup analysis revealed that PM2.5 has a significant correlation with ALT (5.07%, 95% CI: 0.81–9.33%), AST (4.11%, 95% CI: 0.74–7.48%), and GGT (2.74%, 95% CI: 1.09–4.38%) in Asia. Our meta-analysis showed that increments in PM2.5 exposure were significantly associated with a higher level of ALT, AST, and GGT. In addition, investigations into liver enzyme subtypes and specific chemical components of PM2.5 are important directions for future research.

Suggested Citation

  • Ling Pan & Jing Sui & Ying Xu & Qun Zhao & Yinyin Cai & Guiju Sun & Hui Xia, 2023. "Effect of Fine Particulate Matter Exposure on Liver Enzymes: A Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 20(4), pages 1-11, February.
    • Handle: RePEc:gam:jijerp:v:20:y:2023:i:4:p:2803-:d:1058196
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/20/4/2803/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/20/4/2803/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Jing Sui & Hui Xia & Qun Zhao & Guiju Sun & Yinyin Cai, 2022. "Long-Term Exposure to Fine Particulate Matter and the Risk of Chronic Liver Diseases: A Meta-Analysis of Observational Studies," IJERPH, MDPI, vol. 19(16), pages 1-13, August.
    2. Jinxia Xu & Wei Zhang & Zhongbing Lu & Fang Zhang & Wenjun Ding, 2017. "Airborne PM 2.5 -Induced Hepatic Insulin Resistance by Nrf2/JNK-Mediated Signaling Pathway," IJERPH, MDPI, vol. 14(7), pages 1-15, July.
    3. Hong-Bae Kim & Jae-Yong Shim & Byoungjin Park & Yong-Jae Lee, 2018. "Long-Term Exposure to Air Pollutants and Cancer Mortality: A Meta-Analysis of Cohort Studies," IJERPH, MDPI, vol. 15(11), pages 1-15, November.
    4. Athanasios Valavanidis & Thomais Vlachogianni & Konstantinos Fiotakis & Spyridon Loridas, 2013. "Pulmonary Oxidative Stress, Inflammation and Cancer: Respirable Particulate Matter, Fibrous Dusts and Ozone as Major Causes of Lung Carcinogenesis through Reactive Oxygen Species Mechanisms," IJERPH, MDPI, vol. 10(9), pages 1-22, August.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Roberto Cazzolla Gatti, 2021. "Why We Will Continue to Lose Our Battle with Cancers If We Do Not Stop Their Triggers from Environmental Pollution," IJERPH, MDPI, vol. 18(11), pages 1-19, June.
    2. Yue Wang & Yi Huang & Chen Li, 2023. "The Effects of Air Pollutants on Mortality in the Elderly at Different Ages: A Case of the Prefecture with Most Serious Aging in China," Sustainability, MDPI, vol. 15(22), pages 1-14, November.
    3. Sharon A. McClellan & Robert Wright & Farooq Muhammed & Linda D. Hazlett, 2024. "Impact of Airborne Exposure to PM 10 Increases Susceptibility to P. aeruginosa Infection," IJERPH, MDPI, vol. 21(6), pages 1-17, May.
    4. Shih-Chiang Hung & Hsiao-Yuan Cheng & Chen-Cheng Yang & Chia-I Lin & Chi-Kung Ho & Wen-Huei Lee & Fu-Jen Cheng & Chao-Jui Li & Hung-Yi Chuang, 2021. "The Association of White Blood Cells and Air Pollutants—A Population-Based Study," IJERPH, MDPI, vol. 18(5), pages 1-13, March.
    5. Bing-Yu Niu & Wen-Ke Li & Jiang-Shuai Li & Qi-Hao Hong & Sara Khodahemmati & Jing-Feng Gao & Zhi-Xiang Zhou, 2020. "Effects of DNA Damage and Oxidative Stress in Human Bronchial Epithelial Cells Exposed to PM 2.5 from Beijing, China, in Winter," IJERPH, MDPI, vol. 17(13), pages 1-15, July.
    6. Wei Wen & Tongxin Hua & Lei Liu & Xiaoyu Liu & Xin Ma & Song Shen & Zifan Deng, 2023. "Oxidative Potential Characterization of Different PM 2.5 Sources and Components in Beijing and the Surrounding Region," IJERPH, MDPI, vol. 20(6), pages 1-18, March.
    7. Kung-Min Wang & Kun-Huang Chen & Chrestella Ayu Hernanda & Shih-Hsien Tseng & Kung-Jeng Wang, 2022. "How Is the Lung Cancer Incidence Rate Associated with Environmental Risks? Machine-Learning-Based Modeling and Benchmarking," IJERPH, MDPI, vol. 19(14), pages 1-19, July.
    8. Antonin Ambroz & Pavel Rossner & Andrea Rossnerova & Katerina Honkova & Alena Milcova & Anna Pastorkova & Jiri Klema & Jana Pulkrabova & Ondrej Parizek & Veronika Vondraskova & Jaroslav Zelenka & Niko, 2022. "Oxidative Stress and Antioxidant Response in Populations of the Czech Republic Exposed to Various Levels of Environmental Pollutants," IJERPH, MDPI, vol. 19(6), pages 1-16, March.
    9. Alessio Facciolà & Giuseppa Visalli & Marianna Pruiti Ciarello & Angela Di Pietro, 2021. "Newly Emerging Airborne Pollutants: Current Knowledge of Health Impact of Micro and Nanoplastics," IJERPH, MDPI, vol. 18(6), pages 1-17, March.
    10. Omolola Okunromade & Jingjing Yin & Clara Ray & Atin Adhikari, 2022. "Air Quality and Cancer Prevalence Trends across the Sub-Saharan African Regions during 2005–2020," IJERPH, MDPI, vol. 19(18), pages 1-18, September.
    11. Laura Franza & Rossella Cianci, 2021. "Pollution, Inflammation, and Vaccines: A Complex Crosstalk," IJERPH, MDPI, vol. 18(12), pages 1-16, June.
    12. Ammar Javed & Farheen Aamir & Umar Farooq Gohar & Hamid Mukhtar & Muhammad Zia-UI-Haq & Modhi O. Alotaibi & May Nasser Bin-Jumah & Romina Alina Marc (Vlaic) & Oana Lelia Pop, 2021. "The Potential Impact of Smog Spell on Humans’ Health Amid COVID-19 Rages," IJERPH, MDPI, vol. 18(21), pages 1-19, October.
    13. Leonardo Alberghini & Alessandro Truant & Serena Santonicola & Giampaolo Colavita & Valerio Giaccone, 2022. "Microplastics in Fish and Fishery Products and Risks for Human Health: A Review," IJERPH, MDPI, vol. 20(1), pages 1-17, December.
    14. Vanessa Santos-Sánchez & Juan Antonio Córdoba-Doña & Javier García-Pérez & Antonio Escolar-Pujolar & Lucia Pozzi & Rebeca Ramis, 2020. "Cancer Mortality and Deprivation in the Proximity of Polluting Industrial Facilities in an Industrial Region of Spain," IJERPH, MDPI, vol. 17(6), pages 1-15, March.
    15. Jagriti Saini & Maitreyee Dutta & Gonçalo Marques, 2020. "Indoor Air Quality Monitoring Systems Based on Internet of Things: A Systematic Review," IJERPH, MDPI, vol. 17(14), pages 1-22, July.
    16. Melania Maria Serafini & Ambra Maddalon & Martina Iulini & Valentina Galbiati, 2022. "Air Pollution: Possible Interaction between the Immune and Nervous System?," IJERPH, MDPI, vol. 19(23), pages 1-24, November.
    17. Chenying Li & Tiantian Zhang & Xi Wang & Zefeng Lian, 2022. "Site Selection of Urban Parks Based on Fuzzy-Analytic Hierarchy Process (F-AHP): A Case Study of Nanjing, China," IJERPH, MDPI, vol. 19(20), pages 1-27, October.
    18. David Rojas-Rueda & Emily Morales-Zamora & Wael Abdullah Alsufyani & Christopher H. Herbst & Salem M. AlBalawi & Reem Alsukait & Mashael Alomran, 2021. "Environmental Risk Factors and Health: An Umbrella Review of Meta-Analyses," IJERPH, MDPI, vol. 18(2), pages 1-38, January.
    19. Miyoun Shin & Ok-Jin Kim & Seongwoo Yang & Seung-Ah Choe & Sun-Young Kim, 2022. "Different Mortality Risks of Long-Term Exposure to Particulate Matter across Different Cancer Sites," IJERPH, MDPI, vol. 19(6), pages 1-13, March.
    20. Jing Sui & Hui Xia & Qun Zhao & Guiju Sun & Yinyin Cai, 2022. "Long-Term Exposure to Fine Particulate Matter and the Risk of Chronic Liver Diseases: A Meta-Analysis of Observational Studies," IJERPH, MDPI, vol. 19(16), pages 1-13, August.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:20:y:2023:i:4:p:2803-:d:1058196. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.