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The Role of Neighborhood Air Pollution Exposure on Somatic Non-Small Cell Lung Cancer Mutations in the Los Angeles Basin (2013–2018)

Author

Listed:
  • Noémie Letellier

    (Scripps Institution of Oceanography, University of California San Diego, La Jolla, San Diego, CA 92093, USA)

  • Sam E. Wing

    (Department of Population Sciences, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA)

  • Jiue-An Yang

    (Department of Population Sciences, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA)

  • Stacy W. Gray

    (Department of Population Sciences, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA)

  • Tarik Benmarhnia

    (Scripps Institution of Oceanography, University of California San Diego, La Jolla, San Diego, CA 92093, USA)

  • Loretta Erhunmwunsee

    (Department of Population Sciences, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA
    Department of Surgery, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA)

  • Marta M. Jankowska

    (Department of Population Sciences, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA)

Abstract

Limited previous work has identified a relationship between exposure to ambient air pollution and aggressive somatic lung tumor mutations. More work is needed to confirm this relationship, especially using spatially resolved air pollution. We aimed to quantify the association between different air pollution metrics and aggressive tumor biology. Among patients treated at City of Hope Comprehensive Cancer Center in Duarte, CA (2013–2018), three non-small cell lung cancer somatic tumor mutations, TP53 , KRAS , and KRAS G12C / V , were documented. PM 2.5 exposure was assessed using state-of-the art ensemble models five and ten years before lung cancer diagnosis. We also explored the role of NO 2 using inverse-distance-weighting approaches. We fitted logistic regression models to estimate odds ratio (OR) and their 95% confidence intervals (CIs). Among 435 participants (median age: 67, female: 51%), an IQR increase in NO 2 exposure (3.5 μg/m 3 ) five years before cancer diagnosis was associated with an increased risk in TP53 mutation (OR, 95% CI: 1.30, 0.99–1.71). We found an association between highly-exposed participants to PM 2.5 (>12 μg/m 3 ) five and ten years before cancer diagnosis and TP53 mutation (OR, 95% CI: 1.61, 0.95–2.73; 1.57, 0.93–2.64, respectively). Future studies are needed to confirm this association and better understand how air pollution impacts somatic profiles and the molecular mechanisms through which they operate.

Suggested Citation

  • Noémie Letellier & Sam E. Wing & Jiue-An Yang & Stacy W. Gray & Tarik Benmarhnia & Loretta Erhunmwunsee & Marta M. Jankowska, 2022. "The Role of Neighborhood Air Pollution Exposure on Somatic Non-Small Cell Lung Cancer Mutations in the Los Angeles Basin (2013–2018)," IJERPH, MDPI, vol. 19(17), pages 1-10, September.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:17:p:11027-:d:905879
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    References listed on IDEAS

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    1. van Buuren, Stef & Groothuis-Oudshoorn, Karin, 2011. "mice: Multivariate Imputation by Chained Equations in R," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 45(i03).
    2. Hong-Bae Kim & Jae-Yong Shim & Byoungjin Park & Yong-Jae Lee, 2018. "Long-Term Exposure to Air Pollutants and Cancer Mortality: A Meta-Analysis of Cohort Studies," IJERPH, MDPI, vol. 15(11), pages 1-15, November.
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