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In Vitro and In Vivo Experimental Studies of PM 2.5 on Disease Progression

Author

Listed:
  • Ching-Chang Cho

    (Department of Biological Science and Technology, National Chiao Tung University, 75 Boai Street, Hsinchu 300, Taiwan)

  • Wen-Yeh Hsieh

    (Division of Chest Medicine, Department of Internal Medicine, Hsinchu Mackay Memorial Hospital, 690 Section 2, Guangfu Road, Hsinchu 300, Taiwan)

  • Chin-Hung Tsai

    (Department of Biological Science and Technology, National Chiao Tung University, 75 Boai Street, Hsinchu 300, Taiwan
    Division of Pulmonary Medicine, Department of Internal Medicine, Tungs’ Taichung Metro Harbor Hospital, 699 Section 8, Taiwan Blvd., Taichung 435, Taiwan)

  • Cheng-Yi Chen

    (Department of Biological Science and Technology, National Chiao Tung University, 75 Boai Street, Hsinchu 300, Taiwan
    Division of Nephrology, Department of Internal Medicine, Hsinchu Mackay Memorial Hospital, 690 Section 2, Guangfu Road, Hsinchu 300, Taiwan)

  • Hui-Fang Chang

    (Department of Biological Science and Technology, National Chiao Tung University, 75 Boai Street, Hsinchu 300, Taiwan
    Division of Endocrinology, Department of Internal Medicine, Hsinchu Mackay Memorial Hospital, 690 Section 2, Guangfu Road, Hsinchu 300, Taiwan)

  • Chih-Sheng Lin

    (Department of Biological Science and Technology, National Chiao Tung University, 75 Boai Street, Hsinchu 300, Taiwan)

Abstract

Air pollution is a very critical issue worldwide, particularly in developing countries. Particulate matter (PM) is a type of air pollution that comprises a heterogeneous mixture of different particle sizes and chemical compositions. There are various sources of fine PM (PM 2.5 ), and the components may also have different effects on people. The pathogenesis of PM 2.5 in several diseases remains to be clarified. There is a long history of epidemiological research on PM 2.5 in several diseases. Numerous studies show that PM 2.5 can induce a variety of chronic diseases, such as respiratory system damage, cardiovascular dysfunction, and diabetes mellitus. However, the epidemiological evidence associated with potential mechanisms in the progression of diseases need to be proved precisely through in vitro and in vivo investigations. Suggested mechanisms of PM 2.5 that lead to adverse effects and chronic diseases include increasing oxidative stress, inflammatory responses, and genotoxicity. The aim of this review is to provide a brief overview of in vitro and in vivo experimental studies of PM 2.5 in the progression of various diseases from the last decade. The summarized research results could provide clear information about the mechanisms and progression of PM 2.5 -induced disease.

Suggested Citation

  • Ching-Chang Cho & Wen-Yeh Hsieh & Chin-Hung Tsai & Cheng-Yi Chen & Hui-Fang Chang & Chih-Sheng Lin, 2018. "In Vitro and In Vivo Experimental Studies of PM 2.5 on Disease Progression," IJERPH, MDPI, vol. 15(7), pages 1-26, July.
    • Handle: RePEc:gam:jijerp:v:15:y:2018:i:7:p:1380-:d:155492
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    References listed on IDEAS

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    1. Bin Luo & Hongxia Shi & Lina Wang & Yanrong Shi & Cheng Wang & Jingli Yang & Yaxiong Wan & Jingping Niu, 2014. "Rat Lung Response to PM 2.5 Exposure under Different Cold Stresses," IJERPH, MDPI, vol. 11(12), pages 1-12, December.
    2. Chenchen Wang & Yifan Tu & Zongliang Yu & Rongzhu Lu, 2015. "PM 2.5 and Cardiovascular Diseases in the Elderly: An Overview," IJERPH, MDPI, vol. 12(7), pages 1-11, July.
    3. Yiling Pei & Rongfang Jiang & Yunzeng Zou & Yu Wang & Suhui Zhang & Guanghe Wang & Jinzhuo Zhao & Weimin Song, 2016. "Effects of Fine Particulate Matter (PM 2.5 ) on Systemic Oxidative Stress and Cardiac Function in ApoE −/− Mice," IJERPH, MDPI, vol. 13(5), pages 1-15, May.
    4. Athanasios Valavanidis & Thomais Vlachogianni & Konstantinos Fiotakis & Spyridon Loridas, 2013. "Pulmonary Oxidative Stress, Inflammation and Cancer: Respirable Particulate Matter, Fibrous Dusts and Ozone as Major Causes of Lung Carcinogenesis through Reactive Oxygen Species Mechanisms," IJERPH, MDPI, vol. 10(9), pages 1-22, August.
    5. Shang-Shyue Tsai & Chih-Ching Chang & Chun-Yuh Yang, 2013. "Fine Particulate Air Pollution and Hospital Admissions for Chronic Obstructive Pulmonary Disease: A Case-Crossover Study in Taipei," IJERPH, MDPI, vol. 10(11), pages 1-12, November.
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    Cited by:

    1. Yuanni Huang & Mian Bao & Jiefeng Xiao & Zhaolong Qiu & Kusheng Wu, 2019. "Effects of PM 2.5 on Cardio-Pulmonary Function Injury in Open Manganese Mine Workers," IJERPH, MDPI, vol. 16(11), pages 1-10, June.
    2. Daoru Liu & Qinli Deng & Zeng Zhou & Yaolin Lin & Junwei Tao, 2018. "Variation Trends of Fine Particulate Matter Concentration in Wuhan City from 2013 to 2017," IJERPH, MDPI, vol. 15(7), pages 1-18, July.
    3. Jiyun Jung & Jae Yoon Park & Yong Chul Kim & Hyewon Lee & Ejin Kim & Yong-Lim Kim & Yon Su Kim & Jung Pyo Lee & Ho Kim & Clinical Research Center for End-Stage Renal Disease (CRC for ESRD) Investigato, 2020. "Long-Term Effects of Air Pollutants on Mortality Risk in Patients with End-Stage Renal Disease," IJERPH, MDPI, vol. 17(2), pages 1-12, January.
    4. Yueming Wen & Jiawei Leng & Xiaobing Shen & Gang Han & Lijun Sun & Fei Yu, 2020. "Environmental and Health Effects of Ventilation in Subway Stations: A Literature Review," IJERPH, MDPI, vol. 17(3), pages 1-37, February.

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