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Ten-Year Probabilities of Death Due to Cancer and Cardiovascular Disease among Breast Cancer Patients Diagnosed in North-Eastern Spain

Author

Listed:
  • Ramon Clèries

    (Pla Director d’Oncología, Av Gran Vía 199-203, 08908 L’Hospitalet de Llobregat, Barcelona, Spain
    Bellvitge Biomedical Research Institute, IDIBELL, Av. Gran Via de l’Hospitalet, 199-203-1a planta, 08908 L’Hospitalet de Llobregat, Barcelona, Spain
    Clinical Sciences Department, Universitat de Barcelona, 08907 Barcelona, Spain)

  • Alberto Ameijide

    (Tarragona Cancer Registry, Epidemiology and Cancer Prevention Service, Hospital Universitari Sant Joan de Reus, IISPV, 43204 Reus, Spain)

  • Maria Buxó

    (Girona Biomedical Research Institute, IDIBGI, C/Dr. Castany s/n, Edifici M2, Parc Hospitalari Martí i Julià, 17190 Salt, Spain)

  • Mireia Vilardell

    (Independent Researcher, 08700 Barcelona, Spain)

  • José Miguel Martínez

    (Statistics and Operational Research Department, Universitat Politècnica de Catalunya, EDIFICI H, Diagonal 647, 08028 Barcelona, Spain
    Public Health Research Group, University of Alicante, 03690 Alicante, Spain)

  • Rebeca Font

    (Pla Director d’Oncología, Av Gran Vía 199-203, 08908 L’Hospitalet de Llobregat, Barcelona, Spain
    Bellvitge Biomedical Research Institute, IDIBELL, Av. Gran Via de l’Hospitalet, 199-203-1a planta, 08908 L’Hospitalet de Llobregat, Barcelona, Spain)

  • Rafael Marcos-Gragera

    (Girona Biomedical Research Institute, IDIBGI, C/Dr. Castany s/n, Edifici M2, Parc Hospitalari Martí i Julià, 17190 Salt, Spain
    Girona Cancer Registry, Epidemiology Unit, Pla Director d’Oncologia, Institut Català d’Oncología, Group for Descriptive Epidemiology, Genetics and Cancer Prevention, Girona-IDIBGI, 17005 Girona, Spain
    Medical School, Universitat de Girona (UdG), 17071 Girona, Spain
    Epidemiology and Public Health Research Network Centre (CIBERESP), 28029 Madrid, Spain)

  • Montse Puigdemont

    (Girona Cancer Registry, Epidemiology Unit, Pla Director d’Oncologia, Institut Català d’Oncología, Group for Descriptive Epidemiology, Genetics and Cancer Prevention, Girona-IDIBGI, 17005 Girona, Spain)

  • Gemma Viñas

    (Medical Oncology Service, Catalan Institute of Oncology, Hospital Universitari de Girona “Doctor Josep Trueta”, 17005 Girona, Spain)

  • Marià Carulla

    (Tarragona Cancer Registry, Epidemiology and Cancer Prevention Service, Hospital Universitari Sant Joan de Reus, IISPV, 43204 Reus, Spain)

  • Josep Alfons Espinàs

    (Pla Director d’Oncología, Av Gran Vía 199-203, 08908 L’Hospitalet de Llobregat, Barcelona, Spain
    Bellvitge Biomedical Research Institute, IDIBELL, Av. Gran Via de l’Hospitalet, 199-203-1a planta, 08908 L’Hospitalet de Llobregat, Barcelona, Spain)

  • Jaume Galceran

    (Tarragona Cancer Registry, Epidemiology and Cancer Prevention Service, Hospital Universitari Sant Joan de Reus, IISPV, 43204 Reus, Spain)

  • Ángel Izquierdo

    (Girona Cancer Registry, Epidemiology Unit, Pla Director d’Oncologia, Institut Català d’Oncología, Group for Descriptive Epidemiology, Genetics and Cancer Prevention, Girona-IDIBGI, 17005 Girona, Spain
    Medical Oncology Service, Catalan Institute of Oncology, Hospital Universitari de Girona “Doctor Josep Trueta”, 17005 Girona, Spain)

  • Josep Maria Borràs

    (Pla Director d’Oncología, Av Gran Vía 199-203, 08908 L’Hospitalet de Llobregat, Barcelona, Spain
    Bellvitge Biomedical Research Institute, IDIBELL, Av. Gran Via de l’Hospitalet, 199-203-1a planta, 08908 L’Hospitalet de Llobregat, Barcelona, Spain
    Clinical Sciences Department, Universitat de Barcelona, 08907 Barcelona, Spain)

Abstract

Mortality from cardiovascular disease (CVD), second tumours, and other causes is of clinical interest in the long-term follow-up of breast cancer (BC) patients. Using a cohort of BC patients (N = 6758) from the cancer registries of Girona and Tarragona (north-eastern Spain), we studied the 10-year probabilities of death due to BC, other cancers, and CVD according to stage at diagnosis and hormone receptor (HR) status. Among the non-BC causes of death (N = 720), CVD (N = 218) surpassed other cancers (N = 196). The BC cohort presented a significantly higher risk of death due to endometrial and ovarian cancers than the general population. In Stage I, HR− patients showed a 1.72-fold higher probability of all-cause death and a 6.11-fold higher probability of breast cancer death than HR+ patients. In Stages II–III, the probability of CVD death (range 3.11% to 3.86%) surpassed that of other cancers (range 0.54% to 3.11%). In Stage IV patients, the probability of death from any cancer drove the mortality risk. Promoting screening and preventive measures in BC patients are warranted, since long-term control should encompass early detection of second neoplasms, ruling out the possibility of late recurrence. In patients diagnosed in Stages II–III at an older age, surveillance for preventing late cardiotoxicity is crucial.

Suggested Citation

  • Ramon Clèries & Alberto Ameijide & Maria Buxó & Mireia Vilardell & José Miguel Martínez & Rebeca Font & Rafael Marcos-Gragera & Montse Puigdemont & Gemma Viñas & Marià Carulla & Josep Alfons Espinàs &, 2022. "Ten-Year Probabilities of Death Due to Cancer and Cardiovascular Disease among Breast Cancer Patients Diagnosed in North-Eastern Spain," IJERPH, MDPI, vol. 20(1), pages 1-17, December.
    • Handle: RePEc:gam:jijerp:v:20:y:2022:i:1:p:405-:d:1016087
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    References listed on IDEAS

    as
    1. Ramon Clèries & Maria Buxó & Mireia Vilardell & Alberto Ameijide & José Miguel Martínez & Rebeca Font & Rafael Marcos-Gragera & Montse Puigdemont & Gemma Viñas & Marià Carulla & Josep Alfons Espinàs &, 2022. "No Excess Mortality up to 10 Years in Early Stages of Breast Cancer in Women Adherent to Oral Endocrine Therapy: A Probabilistic Graphical Modeling Approach," IJERPH, MDPI, vol. 19(6), pages 1-17, March.
    2. Sturtz, Sibylle & Ligges, Uwe & Gelman, Andrew, 2005. "R2WinBUGS: A Package for Running WinBUGS from R," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 12(i03).
    3. Paula Peremiquel-Trillas & Jon Frias-Gomez & Laia Alemany & Alberto Ameijide & Mireia Vilardell & Rafael Marcos-Gragera & Sònia Paytubi & Jordi Ponce & José Manuel Martínez & Marta Pineda & Joan Brune, 2022. "Predicting Ovarian-Cancer Burden in Catalonia by 2030: An Age–Period–Cohort Modelling," IJERPH, MDPI, vol. 19(3), pages 1-8, January.
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