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Oral-Health-Related Quality of Life in Patients with Medication-Related Osteonecrosis of the Jaw: A Prospective Clinical Study

Author

Listed:
  • Anna Winter

    (Department of Prosthodontics, Julius Maximilian University Würzburg, Pleicherwall 2, 97070 Würzburg, Germany)

  • Stefan M. Schulz

    (Department of Behavioural Medicine and Principles of Human Biology for the Health Sciences, Trier University, Universitätsring 15, 54296 Trier, Germany)

  • Marc Schmitter

    (Department of Prosthodontics, Julius Maximilian University Würzburg, Pleicherwall 2, 97070 Würzburg, Germany)

  • Roman C. Brands

    (Department of Oral and Maxillofacial Plastic Surgery, University Hospital Würzburg, Pleicherwall 2, 97070 Würzburg, Germany)

  • Anton Straub

    (Department of Oral and Maxillofacial Plastic Surgery, University Hospital Würzburg, Pleicherwall 2, 97070 Würzburg, Germany)

  • Alexander Kübler

    (Department of Oral and Maxillofacial Plastic Surgery, University Hospital Würzburg, Pleicherwall 2, 97070 Würzburg, Germany)

  • Anna Borgmann

    (Department of Oral and Maxillofacial Plastic Surgery, University Hospital Würzburg, Pleicherwall 2, 97070 Würzburg, Germany)

  • Stefan Hartmann

    (Department of Oral and Maxillofacial Plastic Surgery, University Hospital Würzburg, Pleicherwall 2, 97070 Würzburg, Germany)

Abstract

Medication-related osteonecrosis of the jaw (MRONJ) represents an adverse side effect of antiresorptive and antiangiogenic medications. It is associated with impaired quality of life, oral health, and oral function and can be classified into various stages. The purpose of this prospective clinical study is to evaluate the impact of stages I and II MRONJ on oral-health-related quality of life (OHRQoL) and related parameters. Patients’ OHRQoL, satisfaction with life, oral discomfort, and oral health were assessed using the German version of the Oral Health Impact Profile (OHIP-G49), visual analog scales (VAS), and Satisfaction with Life Scale (SWLS) at baseline (T0), 10 days (T1), and 3 months after treatment (T2) in 36 patients. Data were analyzed using Kolmogorov–Smirnov test, two-way mixed ANOVAs, and follow-up Mann–Whitney U tests. The impact of treatment effects on the original seven OHIP domain structures and the recently introduced four-dimensional OHIP structure were evaluated using linear regression analysis. Thirty-six patients received surgical MRONJ treatment. Before treatment, patients’ perceived OHRQoL, oral discomfort, oral health, and satisfaction with life were negatively affected by MRONJ. Surgical treatment significantly improved OHRQoL and related parameters (all p ≤ 0.012). This improvement was greater in patients with higher impairment at T0. OHRQoL and oral restrictions were still impaired after treatment in patients who needed prosthetic treatment. The four-dimensional structure revealed valuable information beyond the standard seven OHIP domains. Increased awareness of MRONJ risks and an interdisciplinary treatment approach for MRONJ patients are needed.

Suggested Citation

  • Anna Winter & Stefan M. Schulz & Marc Schmitter & Roman C. Brands & Anton Straub & Alexander Kübler & Anna Borgmann & Stefan Hartmann, 2022. "Oral-Health-Related Quality of Life in Patients with Medication-Related Osteonecrosis of the Jaw: A Prospective Clinical Study," IJERPH, MDPI, vol. 19(18), pages 1-15, September.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:18:p:11709-:d:917059
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    References listed on IDEAS

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    1. Ewa Rodakowska & Jacek Jamiolkowski & Joanna Baginska & Inga Kaminska & Katarzyna Gabiec & Zofia Stachurska & Marcin Kondraciuk & Marlena Dubatowka & Karol Adam Kaminski, 2022. "Oral Health–Related Quality of Life and Missing Teeth in an Adult Population: A Cross-Sectional Study from Poland," IJERPH, MDPI, vol. 19(3), pages 1-10, January.
    2. Giacomo Oteri & Gianluca Trifirò & Matteo Peditto & Loredana Lo Presti & Ilaria Marcianò & Francesco Giorgianni & Janet Sultana & Antonia Marcianò, 2018. "Treatment of Medication-Related Osteonecrosis of the Jaw and its Impact on a Patient’s Quality of Life: A Single-Center, 10-Year Experience from Southern Italy," Drug Safety, Springer, vol. 41(1), pages 111-123, January.
    3. Eitan Mijiritsky & Yael Lerman & Ori Mijiritsky & Asaf Shely & Joseph Meyerson & Maayan Shacham, 2020. "Development and Validation of a Questionnaire Evaluating the Impact of Prosthetic Dental Treatments on Patients’ Oral Health Quality of Life: A Prospective Pilot Study," IJERPH, MDPI, vol. 17(14), pages 1-19, July.
    4. Yuka Kojima & Sakiko Soutome & Mitsunobu Otsuru & Saki Hayashida & Yuki Sakamoto & Shunsuke Sawada & Masahiro Umeda, 2022. "Factors Exacerbating Clinical Symptoms and CT Findings in Patients with Medication-Related Osteonecrosis of the Jaw Receiving Conservative Therapy: A Multicenter Retrospective Study of 53 Cases," IJERPH, MDPI, vol. 19(13), pages 1-12, June.
    5. Olga Di Fede & Federica Canepa & Vera Panzarella & Rodolfo Mauceri & Carmine Del Gaizo & Alberto Bedogni & Vittorio Fusco & Pietro Tozzo & Giuseppe Pizzo & Giuseppina Campisi & Antonio Galvano, 2021. "The Treatment of Medication-Related Osteonecrosis of the Jaw (MRONJ): A Systematic Review with a Pooled Analysis of Only Surgery versus Combined Protocols," IJERPH, MDPI, vol. 18(16), pages 1-23, August.
    6. Giuseppina Campisi & Rodolfo Mauceri & Francesco Bertoldo & Giordana Bettini & Matteo Biasotto & Giuseppe Colella & Ugo Consolo & Olga Di Fede & Gianfranco Favia & Vittorio Fusco & Mario Gabriele & An, 2020. "Medication-Related Osteonecrosis of Jaws (MRONJ) Prevention and Diagnosis: Italian Consensus Update 2020," IJERPH, MDPI, vol. 17(16), pages 1-15, August.
    7. Mayte Buchbender & Charlotte Bauerschmitz & Sebastian Pirkl & Marco R. Kesting & Christian M. Schmitt, 2022. "A Retrospective Data Analysis for the Risk Evaluation of the Development of Drug-Associated Jaw Necrosis through Dentoalveolar Interventions," IJERPH, MDPI, vol. 19(7), pages 1-14, April.
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    1. Anton Straub & Maximilian Stapf & Markus Fischer & Andreas Vollmer & Christian Linz & Thiên-Trí Lâm & Alexander Kübler & Roman C. Brands & Oliver Scherf-Clavel & Stefan Hartmann, 2022. "Bone Concentration of Ampicillin/Sulbactam: A Pilot Study in Patients with Osteonecrosis of the Jaw," IJERPH, MDPI, vol. 19(22), pages 1-12, November.

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