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Treatment of Stage 2 Medication-Induced Osteonecrosis of the Jaw: A Case Series

Author

Listed:
  • Guillermo Pardo-Zamora

    (Department of General Dentistry and Implants, Faculty of Medicine and Dentistry, University of Murcia, 30008 Murcia, Spain)

  • Yanet Martínez

    (Department of General Dentistry and Implants, Faculty of Medicine and Dentistry, University of Murcia, 30008 Murcia, Spain)

  • Jose Antonio Moreno

    (Department of General Dentistry and Implants, Faculty of Medicine and Dentistry, University of Murcia, 30008 Murcia, Spain)

  • Antonio J. Ortiz-Ruíz

    (Department of General Dentistry and Implants, Faculty of Medicine and Dentistry, University of Murcia, 30008 Murcia, Spain)

Abstract

Medication-induced jaw osteonecrosis (MRONJ) is a rare and serious disease with a negative impact on patients’ quality of life, whose exact cause remains unclear and which may have a multifactorial origin. Although there are different therapeutic protocols, there is still no consensus. This case series evaluated three patients diagnosed with staged 2 MRONJ treated at the University of Murcia dental clinic according to the protocols described by the Spanish Society of Oral and Maxillofacial Surgery and the American Association of Oral and Maxillofacial Surgeons. Within 12 months of the application of therapeutic protocols, the lesions were completely healed in all cases. Radiography showed slow but progressive healing with normal bone structure. Conservative treatment with antibiotics, chlorhexidine rinses and minimally invasive surgical intervention with necrotic bone resection is effective in treating stage 2 of MRONJ. In cases of refractory osteonecrosis, the application of platelet and leukocyte-rich fibrin (PRF-L) in the surgical approach improves the outcome in soft tissue healing and bone regeneration but further research is needed to confirm its effectiveness.

Suggested Citation

  • Guillermo Pardo-Zamora & Yanet Martínez & Jose Antonio Moreno & Antonio J. Ortiz-Ruíz, 2021. "Treatment of Stage 2 Medication-Induced Osteonecrosis of the Jaw: A Case Series," IJERPH, MDPI, vol. 18(3), pages 1-18, January.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:3:p:1018-:d:486089
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    References listed on IDEAS

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    1. Giuseppina Campisi & Rodolfo Mauceri & Francesco Bertoldo & Giordana Bettini & Matteo Biasotto & Giuseppe Colella & Ugo Consolo & Olga Di Fede & Gianfranco Favia & Vittorio Fusco & Mario Gabriele & An, 2020. "Medication-Related Osteonecrosis of Jaws (MRONJ) Prevention and Diagnosis: Italian Consensus Update 2020," IJERPH, MDPI, vol. 17(16), pages 1-15, August.
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