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Medication-Related Osteonecrosis of Jaws (MRONJ) Prevention and Diagnosis: Italian Consensus Update 2020

Author

Listed:
  • Giuseppina Campisi

    (Department of Surgical, Oncological, and Oral Sciences, University of Palermo, 90127 Palermo, Italy
    IAC-ONJ (Italian Allied Committee on ONJ), Temporary Chair at University of Palermo, 90100 Piazza Marina, Italy)

  • Rodolfo Mauceri

    (Department of Surgical, Oncological, and Oral Sciences, University of Palermo, 90127 Palermo, Italy
    IAC-ONJ (Italian Allied Committee on ONJ), Temporary Chair at University of Palermo, 90100 Piazza Marina, Italy
    Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98124 Messina, Italy)

  • Francesco Bertoldo

    (IAC-ONJ (Italian Allied Committee on ONJ), Temporary Chair at University of Palermo, 90100 Piazza Marina, Italy
    Department of Medicine, University of Verona, 37134 Verona, Italy)

  • Giordana Bettini

    (IAC-ONJ (Italian Allied Committee on ONJ), Temporary Chair at University of Palermo, 90100 Piazza Marina, Italy
    Regional Center for Prevention, Diagnosis and Treatment of Medication and Radiation-Related Bone Diseases of the Head and Neck, University of Padova, 35128 Padova, Italy)

  • Matteo Biasotto

    (Department of Medical, Surgical and Health Sciences, University of Trieste, 34129 Trieste, Italy)

  • Giuseppe Colella

    (Department of Medical, Surgical and Dental Speciality, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy)

  • Ugo Consolo

    (Department of Surgery, Medicine, Dentistry and Morphological Sciences with Transplant Surgery, Oncology and Regenerative Medicine Relevance, University of Modena and Reggio Emilia, 41125 Modena, Italy)

  • Olga Di Fede

    (Department of Surgical, Oncological, and Oral Sciences, University of Palermo, 90127 Palermo, Italy
    IAC-ONJ (Italian Allied Committee on ONJ), Temporary Chair at University of Palermo, 90100 Piazza Marina, Italy)

  • Gianfranco Favia

    (Department of Interdisciplinary Medicine, University of Bari Aldo Moro, 70124 Bari, Italy)

  • Vittorio Fusco

    (IAC-ONJ (Italian Allied Committee on ONJ), Temporary Chair at University of Palermo, 90100 Piazza Marina, Italy
    Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo, 15121 Alessandria, Italy)

  • Mario Gabriele

    (Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, 56126 Pisa, Italy)

  • Antonio Lo Casto

    (Department of Surgical, Oncological, and Oral Sciences, University of Palermo, 90127 Palermo, Italy
    IAC-ONJ (Italian Allied Committee on ONJ), Temporary Chair at University of Palermo, 90100 Piazza Marina, Italy)

  • Lorenzo Lo Muzio

    (Department of Clinical and Experimental Medicine, University of Foggia, 71121 Foggia, Italy)

  • Antonia Marcianò

    (Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98124 Messina, Italy)

  • Marco Mascitti

    (Department of Clinical Specialistic and Dental Sciences, Marche Polytechnic University, 60126 Ancona, Italy)

  • Marco Meleti

    (Department of Medicine and Surgery, University of Parma, 43125 Parma, Italy)

  • Michele D. Mignogna

    (Department of Neuroscience, Reproductive and Odontostomatological Sciences, University of Naples Federico II, 80131 Napoli, Italy)

  • Giacomo Oteri

    (Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98124 Messina, Italy)

  • Vera Panzarella

    (Department of Surgical, Oncological, and Oral Sciences, University of Palermo, 90127 Palermo, Italy
    IAC-ONJ (Italian Allied Committee on ONJ), Temporary Chair at University of Palermo, 90100 Piazza Marina, Italy)

  • Umberto Romeo

    (Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, 00161 Roma, Italy)

  • Andrea Santarelli

    (Department of Clinical Specialistic and Dental Sciences, Marche Polytechnic University, 60126 Ancona, Italy)

  • Paolo Vescovi

    (IAC-ONJ (Italian Allied Committee on ONJ), Temporary Chair at University of Palermo, 90100 Piazza Marina, Italy
    Department of Medicine and Surgery, University of Parma, 43125 Parma, Italy)

  • Claudio Marchetti

    (IAC-ONJ (Italian Allied Committee on ONJ), Temporary Chair at University of Palermo, 90100 Piazza Marina, Italy
    Department of Biomedical and Neuromotor Sciences, University of Bologna, 40125 Bologna, Italy)

  • Alberto Bedogni

    (IAC-ONJ (Italian Allied Committee on ONJ), Temporary Chair at University of Palermo, 90100 Piazza Marina, Italy
    Regional Center for Prevention, Diagnosis and Treatment of Medication and Radiation-Related Bone Diseases of the Head and Neck, University of Padova, 35128 Padova, Italy)

Abstract

The Medication-Related Osteonecrosis of Jaws (MRONJ) diagnosis process and its prevention play a role of great and rising importance, not only on the Quality of Life (QoL) of patients, but also on the decision-making process by the majority of dentists and oral surgeons involved in MRONJ prevention (primary and secondary). The present paper reports the update of the conclusions from the Consensus Conference—held at the Symposium of the Italian Society of Oral Pathology and Medicine (SIPMO) (20 October 2018, Ancona, Italy)—after the newest recommendations (2020) on MRONJ were published by two scientific societies (Italian Societies of Maxillofacial Surgery and Oral Pathology and Medicine, SICMF and SIPMO), written on the inputs of the experts of the Italian Allied Committee on ONJ (IAC-ONJ). The conference focused on the topic of MRONJ, and in particular on the common practices at risk of inappropriateness in MRONJ diagnosis and therapy, as well as on MRONJ prevention and the dental management of patients at risk of MRONJ. It is a matter of cancer and osteometabolic patients that are at risk since being exposed to several drugs with antiresorptive (i.e., bisphosphonates and denosumab) or, more recently, antiangiogenic activities. At the same time, the Conference traced for dentists and oral surgeons some easy applicable indications and procedures to reduce MRONJ onset risk and to diagnose it early. Continuous updating on these issues, so important for the patient community, is recommended.

Suggested Citation

  • Giuseppina Campisi & Rodolfo Mauceri & Francesco Bertoldo & Giordana Bettini & Matteo Biasotto & Giuseppe Colella & Ugo Consolo & Olga Di Fede & Gianfranco Favia & Vittorio Fusco & Mario Gabriele & An, 2020. "Medication-Related Osteonecrosis of Jaws (MRONJ) Prevention and Diagnosis: Italian Consensus Update 2020," IJERPH, MDPI, vol. 17(16), pages 1-15, August.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:16:p:5998-:d:400627
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    Citations

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    Cited by:

    1. Olga Di Fede & Federica Canepa & Vera Panzarella & Rodolfo Mauceri & Carmine Del Gaizo & Alberto Bedogni & Vittorio Fusco & Pietro Tozzo & Giuseppe Pizzo & Giuseppina Campisi & Antonio Galvano, 2021. "The Treatment of Medication-Related Osteonecrosis of the Jaw (MRONJ): A Systematic Review with a Pooled Analysis of Only Surgery versus Combined Protocols," IJERPH, MDPI, vol. 18(16), pages 1-23, August.
    2. Mayte Buchbender & Charlotte Bauerschmitz & Sebastian Pirkl & Marco R. Kesting & Christian M. Schmitt, 2022. "A Retrospective Data Analysis for the Risk Evaluation of the Development of Drug-Associated Jaw Necrosis through Dentoalveolar Interventions," IJERPH, MDPI, vol. 19(7), pages 1-14, April.
    3. Thomas Rückschloß & Julius Moratin & Sven Zittel & Maximilian Pilz & Christoph Roser & Michael Engel & Christian Freudlsperger & Jürgen Hoffmann & Oliver Ristow, 2021. "Influence of Preventive Tooth Extractions on Quality of Life in Patients with Antiresorptive Intake—A Prospective Longitudinal Study," IJERPH, MDPI, vol. 18(21), pages 1-10, November.
    4. Emanuel Bruckmoser & Miriam Palaoro & Lukas Latzko & Dagmar Schnabl & Sabrina B. Neururer & Johannes Laimer, 2021. "Choosing the Right Partner for Medication Related Osteonecrosis of the Jaw: What Central European Dentists Know," IJERPH, MDPI, vol. 18(9), pages 1-10, April.
    5. Ellen Pick & Nicolas Leuenberger & Irina Kuster & Nicole Selina Stutzmann & Bernd Stadlinger & Silvio Valdec, 2021. "Evaluation of Preventive Treatment Protocols for Patients under Antiresorptive Therapy Undergoing Tooth Extraction at a Swiss University Clinic," IJERPH, MDPI, vol. 18(18), pages 1-14, September.
    6. Anna Winter & Stefan M. Schulz & Marc Schmitter & Roman C. Brands & Anton Straub & Alexander Kübler & Anna Borgmann & Stefan Hartmann, 2022. "Oral-Health-Related Quality of Life in Patients with Medication-Related Osteonecrosis of the Jaw: A Prospective Clinical Study," IJERPH, MDPI, vol. 19(18), pages 1-15, September.
    7. Guillermo Pardo-Zamora & Yanet Martínez & Jose Antonio Moreno & Antonio J. Ortiz-Ruíz, 2021. "Treatment of Stage 2 Medication-Induced Osteonecrosis of the Jaw: A Case Series," IJERPH, MDPI, vol. 18(3), pages 1-18, January.
    8. Magdalena Kaczoruk-Wieremczuk & Paulina Adamska & Łukasz Jan Adamski & Piotr Wychowański & Barbara Alicja Jereczek-Fossa & Anna Starzyńska, 2021. "Oral Surgery Procedures in a Patient with Hajdu-Cheney Syndrome Treated with Denosumab—A Rare Case Report," IJERPH, MDPI, vol. 18(17), pages 1-10, August.
    9. Edoardo Brauner & Silvia Mezi & Alessandro Ciolfi & Chiara Ciolfi & Resi Pucci & Andrea Cassoni & Andrea Battisti & Gabriele Piesco & Francesca De Felice & Nicola Pranno & Matteo Armida & Francesca De, 2021. "A New Medical Record Proposal to the Prognostic Risk Assessment for MRONJ in Oncologic Patients: “Sapienza Head and Neck Unit” Proposal," IJERPH, MDPI, vol. 18(4), pages 1-12, February.

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