IDEAS home Printed from https://ideas.repec.org/a/spr/drugsa/v41y2018i1d10.1007_s40264-017-0582-6.html
   My bibliography  Save this article

Treatment of Medication-Related Osteonecrosis of the Jaw and its Impact on a Patient’s Quality of Life: A Single-Center, 10-Year Experience from Southern Italy

Author

Listed:
  • Giacomo Oteri

    (AOU Policlinico “G.Martino”
    University of Messina)

  • Gianluca Trifirò

    (University of Messina
    AOU Policlinico “G. Martino”
    Erasmus Medical Centre)

  • Matteo Peditto

    (University of Messina)

  • Loredana Lo Presti

    (AOU Policlinico “G.Martino”)

  • Ilaria Marcianò

    (AOU Policlinico “G. Martino”)

  • Francesco Giorgianni

    (AOU Policlinico “G. Martino”)

  • Janet Sultana

    (University of Messina
    Erasmus Medical Centre)

  • Antonia Marcianò

    (University of Messina)

Abstract

Introduction No official guidelines are available for the management of medication-related osteonecrosis of the jaw (MR-ONJ). The additional benefit of surgery after pharmacological treatment is debated by both clinicians and patients. Objective The aim of this study was to evaluate the changes in patients’ MR-ONJ-related quality of life (QoL) after pharmacological treatment with or without surgery in a large cohort affected by MR-ONJ. Methods Anonymized data on patients diagnosed with MR-ONJ were extracted from the database of the Osteonecrosis of the Jaw Treatment Center (University of Messina, Italy) in the years 2005–2015. QoL was evaluated at the moment of MR-ONJ diagnoses (T0), after pharmacological treatment with or without surgery (T1 and T2, respectively), based on scores from the European Organisation for Research and Treatment of Cancer (EORTC) QOL Module for Head and Neck Cancer (global oral health status [GOHS]) and a visual analog scale (VAS), stratified by indication for use. Results Among 100 patients, 36% were affected by osteoporosis (OSTEO group) and 64% were affected by cancer (ONC group). Considering T0, QoL scores were higher in the OSTEO group then in the ONC group. At T1, GOHS and VAS increased in both groups (OSTEO group: +9.9% and +39.9%; ONC group: +35.4 and +97.2%, respectively). Pharmacological treatment was effective in reducing pain (OSTEO group: −22.0%; ONC group: −44.8%), and social contact troubles (OSTEO group: −40.3%; ONC group: −26.7%). At T2, GOHS and VAS further increased. Scores related to ‘pain’ and the troubles related to the ‘social dimension’ also decreased (OSTEO group: −91.3% and −72.0%; ONC group: 50.8% and −16.4%, respectively). Conclusions MR-ONJ-related QoL increased after pharmacological treatment and, more notably, after surgery, which may offer benefits to selected patients. QoL data may help clinicians in promoting tailored management of MR-ONJ.

Suggested Citation

  • Giacomo Oteri & Gianluca Trifirò & Matteo Peditto & Loredana Lo Presti & Ilaria Marcianò & Francesco Giorgianni & Janet Sultana & Antonia Marcianò, 2018. "Treatment of Medication-Related Osteonecrosis of the Jaw and its Impact on a Patient’s Quality of Life: A Single-Center, 10-Year Experience from Southern Italy," Drug Safety, Springer, vol. 41(1), pages 111-123, January.
    • Handle: RePEc:spr:drugsa:v:41:y:2018:i:1:d:10.1007_s40264-017-0582-6
    DOI: 10.1007/s40264-017-0582-6
    as

    Download full text from publisher

    File URL: http://link.springer.com/10.1007/s40264-017-0582-6
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1007/s40264-017-0582-6?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Thomas Rückschloß & Julius Moratin & Sven Zittel & Maximilian Pilz & Christoph Roser & Michael Engel & Christian Freudlsperger & Jürgen Hoffmann & Oliver Ristow, 2021. "Influence of Preventive Tooth Extractions on Quality of Life in Patients with Antiresorptive Intake—A Prospective Longitudinal Study," IJERPH, MDPI, vol. 18(21), pages 1-10, November.
    2. Anna Winter & Stefan M. Schulz & Marc Schmitter & Roman C. Brands & Anton Straub & Alexander Kübler & Anna Borgmann & Stefan Hartmann, 2022. "Oral-Health-Related Quality of Life in Patients with Medication-Related Osteonecrosis of the Jaw: A Prospective Clinical Study," IJERPH, MDPI, vol. 19(18), pages 1-15, September.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:spr:drugsa:v:41:y:2018:i:1:d:10.1007_s40264-017-0582-6. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.springer.com/economics/journal/40264 .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.