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Influence of Preventive Tooth Extractions on Quality of Life in Patients with Antiresorptive Intake—A Prospective Longitudinal Study

Author

Listed:
  • Thomas Rückschloß

    (Department of Oral and Maxillofacial Surgery, University of Heidelberg, Im Neuenheimer Feld 400, D-69120 Heidelberg, Germany)

  • Julius Moratin

    (Department of Oral and Maxillofacial Surgery, University of Heidelberg, Im Neuenheimer Feld 400, D-69120 Heidelberg, Germany)

  • Sven Zittel

    (Department of Oral and Maxillofacial Surgery, University of Heidelberg, Im Neuenheimer Feld 400, D-69120 Heidelberg, Germany)

  • Maximilian Pilz

    (Department of Biometry, Institute of Medical Biometry and Informatics, University of Heidelberg, Im Neuenheimer Feld 130.3, D-69120 Heidelberg, Germany)

  • Christoph Roser

    (Department of Orthodontics, University of Heidelberg, Im Neuenheimer Feld 400, D-69120 Heidelberg, Germany)

  • Michael Engel

    (Department of Oral and Maxillofacial Surgery, University of Heidelberg, Im Neuenheimer Feld 400, D-69120 Heidelberg, Germany)

  • Christian Freudlsperger

    (Department of Oral and Maxillofacial Surgery, University of Heidelberg, Im Neuenheimer Feld 400, D-69120 Heidelberg, Germany)

  • Jürgen Hoffmann

    (Department of Oral and Maxillofacial Surgery, University of Heidelberg, Im Neuenheimer Feld 400, D-69120 Heidelberg, Germany)

  • Oliver Ristow

    (Department of Oral and Maxillofacial Surgery, University of Heidelberg, Im Neuenheimer Feld 400, D-69120 Heidelberg, Germany)

Abstract

Background: To find out whether preventive tooth extractions in patients on antiresorptive therapy have a direct impact on the patients’ overall quality of life (QoL); Methods: QoL using the five-level version of the EuroQol Group’s EQ-5D instrument (EQ-5D-5L) was longitudinally assessed in N = 114 prospectively enrolled patients with indication of preventive tooth extraction over a period of 12 months. Patients were stratified as high-risk (malignant disease with bone metastasis or multiple myeloma, with monthly high-dose antiresorptive therapy delivered intravenously [bisphosphonate] or subcutaneously [denosumab]) and low-risk/osteoporosis patients (weekly low-dose antiresorptive therapy administered orally [bisphosphonate] or half-yearly subcutaneously [denosumab]). The measurement time points were 4 weeks preoperatively (T0), 2 months (T1) and 1 year postoperatively (T2), respectively. Results: EQ-5D-5L index scores fell in a range from −0.21 to 1.00 in the low-risk group to 0.15 to 1.00 in the high-risk group. The t -test comparing the baseline index scores of both groups showed EQ-5D-5L index score in the low-risk group (0.708 ± 0.292) to be significantly smaller ( p = 0.037) than in the high-risk group (0.807 ± 0.19). ANCOVA showed no significant differences in EQ-5D-5L index scores between the groups at T1 and T2. Conclusions: Preventive tooth extractions in patients undergoing antiresorptive treatment have no negative effect on QoL. Therefore, if indicated, preventive tooth extraction should not be omitted. Patient-oriented outcome measures are important to obtain a good risk–benefit balance for patient-specific treatment.

Suggested Citation

  • Thomas Rückschloß & Julius Moratin & Sven Zittel & Maximilian Pilz & Christoph Roser & Michael Engel & Christian Freudlsperger & Jürgen Hoffmann & Oliver Ristow, 2021. "Influence of Preventive Tooth Extractions on Quality of Life in Patients with Antiresorptive Intake—A Prospective Longitudinal Study," IJERPH, MDPI, vol. 18(21), pages 1-10, November.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:21:p:11650-:d:673412
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    References listed on IDEAS

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    1. Giuseppina Campisi & Rodolfo Mauceri & Francesco Bertoldo & Giordana Bettini & Matteo Biasotto & Giuseppe Colella & Ugo Consolo & Olga Di Fede & Gianfranco Favia & Vittorio Fusco & Mario Gabriele & An, 2020. "Medication-Related Osteonecrosis of Jaws (MRONJ) Prevention and Diagnosis: Italian Consensus Update 2020," IJERPH, MDPI, vol. 17(16), pages 1-15, August.
    2. Giacomo Oteri & Gianluca Trifirò & Matteo Peditto & Loredana Lo Presti & Ilaria Marcianò & Francesco Giorgianni & Janet Sultana & Antonia Marcianò, 2018. "Treatment of Medication-Related Osteonecrosis of the Jaw and its Impact on a Patient’s Quality of Life: A Single-Center, 10-Year Experience from Southern Italy," Drug Safety, Springer, vol. 41(1), pages 111-123, January.
    3. Kristina Ludwig & J.-Matthias Graf von der Schulenburg & Wolfgang Greiner, 2018. "German Value Set for the EQ-5D-5L," PharmacoEconomics, Springer, vol. 36(6), pages 663-674, June.
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