IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v19y2022i7p4339-d786967.html
   My bibliography  Save this article

A Retrospective Data Analysis for the Risk Evaluation of the Development of Drug-Associated Jaw Necrosis through Dentoalveolar Interventions

Author

Listed:
  • Mayte Buchbender

    (Department of Oral and Maxillofacial Surgery, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Glückstraße 11, 91054 Erlangen, Germany
    These authors contributed equally to this work.)

  • Charlotte Bauerschmitz

    (Department of Oral and Maxillofacial Surgery, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Glückstraße 11, 91054 Erlangen, Germany
    These authors contributed equally to this work.)

  • Sebastian Pirkl

    (Department of Oral and Maxillofacial Surgery, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Glückstraße 11, 91054 Erlangen, Germany)

  • Marco R. Kesting

    (Department of Oral and Maxillofacial Surgery, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Glückstraße 11, 91054 Erlangen, Germany)

  • Christian M. Schmitt

    (Department of Oral and Maxillofacial Surgery, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Glückstraße 11, 91054 Erlangen, Germany)

Abstract

This study aimed to analyse the development of medication-related osteonecrosis of the jaw (MRONJ) in patients who underwent surgical intervention to identify potential risk factors between three different groups sorted by the type of oral surgery (single tooth extraction, multiple extraction, osteotomy). Data from patients with this medical history between 2010 and 2017 were retrospectively analysed. The following parameters were collected: sex, age, medical status, surgical intervention location of dentoalveolar intervention and form of medication. A total of 115 patients fulfilled the criteria and underwent 115 dental surgical interventions (female n = 90, male n = 25). In total, 73 (63.47%) of them had metastatic underlying diseases, and 42 (36.52%) had osteoporotic ones. MRONJ occurred in 10 patients (8.70%) (female n = 5, male n = 5). The occurrence of MRONJ was significantly correlated ( p ≤ 0.05) with the mandible site and male sex. Tooth removal at the mandible site remains the main risk factor for the development of MRONJ. The risk profile of developing MRONJ after dentoalveolar interventions could be expected as follows: tooth osteotomy > multiple extractions > single tooth extraction.

Suggested Citation

  • Mayte Buchbender & Charlotte Bauerschmitz & Sebastian Pirkl & Marco R. Kesting & Christian M. Schmitt, 2022. "A Retrospective Data Analysis for the Risk Evaluation of the Development of Drug-Associated Jaw Necrosis through Dentoalveolar Interventions," IJERPH, MDPI, vol. 19(7), pages 1-14, April.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:7:p:4339-:d:786967
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/19/7/4339/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/19/7/4339/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Giuseppina Campisi & Rodolfo Mauceri & Francesco Bertoldo & Giordana Bettini & Matteo Biasotto & Giuseppe Colella & Ugo Consolo & Olga Di Fede & Gianfranco Favia & Vittorio Fusco & Mario Gabriele & An, 2020. "Medication-Related Osteonecrosis of Jaws (MRONJ) Prevention and Diagnosis: Italian Consensus Update 2020," IJERPH, MDPI, vol. 17(16), pages 1-15, August.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Anna Winter & Stefan M. Schulz & Marc Schmitter & Roman C. Brands & Anton Straub & Alexander Kübler & Anna Borgmann & Stefan Hartmann, 2022. "Oral-Health-Related Quality of Life in Patients with Medication-Related Osteonecrosis of the Jaw: A Prospective Clinical Study," IJERPH, MDPI, vol. 19(18), pages 1-15, September.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Thomas Rückschloß & Julius Moratin & Sven Zittel & Maximilian Pilz & Christoph Roser & Michael Engel & Christian Freudlsperger & Jürgen Hoffmann & Oliver Ristow, 2021. "Influence of Preventive Tooth Extractions on Quality of Life in Patients with Antiresorptive Intake—A Prospective Longitudinal Study," IJERPH, MDPI, vol. 18(21), pages 1-10, November.
    2. Guillermo Pardo-Zamora & Yanet Martínez & Jose Antonio Moreno & Antonio J. Ortiz-Ruíz, 2021. "Treatment of Stage 2 Medication-Induced Osteonecrosis of the Jaw: A Case Series," IJERPH, MDPI, vol. 18(3), pages 1-18, January.
    3. Anna Winter & Stefan M. Schulz & Marc Schmitter & Roman C. Brands & Anton Straub & Alexander Kübler & Anna Borgmann & Stefan Hartmann, 2022. "Oral-Health-Related Quality of Life in Patients with Medication-Related Osteonecrosis of the Jaw: A Prospective Clinical Study," IJERPH, MDPI, vol. 19(18), pages 1-15, September.
    4. Emanuel Bruckmoser & Miriam Palaoro & Lukas Latzko & Dagmar Schnabl & Sabrina B. Neururer & Johannes Laimer, 2021. "Choosing the Right Partner for Medication Related Osteonecrosis of the Jaw: What Central European Dentists Know," IJERPH, MDPI, vol. 18(9), pages 1-10, April.
    5. Edoardo Brauner & Silvia Mezi & Alessandro Ciolfi & Chiara Ciolfi & Resi Pucci & Andrea Cassoni & Andrea Battisti & Gabriele Piesco & Francesca De Felice & Nicola Pranno & Matteo Armida & Francesca De, 2021. "A New Medical Record Proposal to the Prognostic Risk Assessment for MRONJ in Oncologic Patients: “Sapienza Head and Neck Unit” Proposal," IJERPH, MDPI, vol. 18(4), pages 1-12, February.
    6. Olga Di Fede & Federica Canepa & Vera Panzarella & Rodolfo Mauceri & Carmine Del Gaizo & Alberto Bedogni & Vittorio Fusco & Pietro Tozzo & Giuseppe Pizzo & Giuseppina Campisi & Antonio Galvano, 2021. "The Treatment of Medication-Related Osteonecrosis of the Jaw (MRONJ): A Systematic Review with a Pooled Analysis of Only Surgery versus Combined Protocols," IJERPH, MDPI, vol. 18(16), pages 1-23, August.
    7. Ellen Pick & Nicolas Leuenberger & Irina Kuster & Nicole Selina Stutzmann & Bernd Stadlinger & Silvio Valdec, 2021. "Evaluation of Preventive Treatment Protocols for Patients under Antiresorptive Therapy Undergoing Tooth Extraction at a Swiss University Clinic," IJERPH, MDPI, vol. 18(18), pages 1-14, September.
    8. Magdalena Kaczoruk-Wieremczuk & Paulina Adamska & Łukasz Jan Adamski & Piotr Wychowański & Barbara Alicja Jereczek-Fossa & Anna Starzyńska, 2021. "Oral Surgery Procedures in a Patient with Hajdu-Cheney Syndrome Treated with Denosumab—A Rare Case Report," IJERPH, MDPI, vol. 18(17), pages 1-10, August.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:19:y:2022:i:7:p:4339-:d:786967. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.