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Molecular Clustering Analysis of Blood Biomarkers in World Trade Center Exposed Community Members with Persistent Lower Respiratory Symptoms

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  • Gabriele Grunig

    (Department of Environmental Medicine, New York University Grossman School of Medicine, New York, NY 10010, USA
    Division of Pulmonary Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, NY 10016, USA)

  • Nedim Durmus

    (Division of Pulmonary Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, NY 10016, USA
    World Trade Center Environmental Health Center, NYC Health + Hospitals, New York, NY 10016, USA)

  • Yian Zhang

    (World Trade Center Environmental Health Center, NYC Health + Hospitals, New York, NY 10016, USA
    Division of Biostatistics, Department of Population Health, New York University Grossman School of Medicine, New York, NY 10016, USA)

  • Yuting Lu

    (World Trade Center Environmental Health Center, NYC Health + Hospitals, New York, NY 10016, USA
    Division of Biostatistics, Department of Population Health, New York University Grossman School of Medicine, New York, NY 10016, USA)

  • Sultan Pehlivan

    (Division of Pulmonary Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, NY 10016, USA)

  • Yuyan Wang

    (World Trade Center Environmental Health Center, NYC Health + Hospitals, New York, NY 10016, USA
    Division of Biostatistics, Department of Population Health, New York University Grossman School of Medicine, New York, NY 10016, USA)

  • Kathleen Doo

    (Pulmonary, Kaiser Permanente East Bay, Oakland, CA 94611, USA)

  • Maria L. Cotrina-Vidal

    (Division of Pulmonary Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, NY 10016, USA)

  • Roberta Goldring

    (Division of Pulmonary Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, NY 10016, USA)

  • Kenneth I. Berger

    (Division of Pulmonary Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, NY 10016, USA)

  • Mengling Liu

    (World Trade Center Environmental Health Center, NYC Health + Hospitals, New York, NY 10016, USA
    Division of Biostatistics, Department of Population Health, New York University Grossman School of Medicine, New York, NY 10016, USA)

  • Yongzhao Shao

    (Department of Environmental Medicine, New York University Grossman School of Medicine, New York, NY 10010, USA
    World Trade Center Environmental Health Center, NYC Health + Hospitals, New York, NY 10016, USA
    Division of Biostatistics, Department of Population Health, New York University Grossman School of Medicine, New York, NY 10016, USA)

  • Joan Reibman

    (Department of Environmental Medicine, New York University Grossman School of Medicine, New York, NY 10010, USA
    Division of Pulmonary Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, NY 10016, USA
    World Trade Center Environmental Health Center, NYC Health + Hospitals, New York, NY 10016, USA)

Abstract

The destruction of the World Trade Center (WTC) on September 11, 2001 (9/11) released large amounts of toxic dusts and fumes into the air that exposed many community members who lived and/or worked in the local area. Many community members, defined as WTC survivors by the federal government, developed lower respiratory symptoms (LRS). We previously reported the persistence of these symptoms in patients with normal spirometry despite treatment with inhaled corticosteroids and/or long-acting bronchodilators. This report expands upon our study of this group with the goal to identify molecular markers associated with exposure and heterogeneity in WTC survivors with LRS using a selected plasma biomarker approach. Samples from WTC survivors with LRS ( n = 73, WTCS) and samples from healthy control participants of the NYU Bellevue Asthma Registry (NYUBAR, n = 55) were compared. WTCS provided information regarding WTC dust exposure intensity. Hierarchical clustering of the linear biomarker data identified two clusters within WTCS and two clusters within NYUBAR controls. Comparison of the WTCS clusters showed that one cluster had significantly increased levels of circulating matrix metalloproteinases (MMP1, 2, 3, 8, 12, 13), soluble inflammatory receptors (receptor for advanced glycation end-products-RAGE, Interleukin-1 receptor antagonist (IL-1RA), suppression of tumorigenicity (ST)2, triggering receptor expressed on myeloid cells (TREM)1, IL-6Ra, tumor necrosis factor (TNF)RI, TNFRII), and chemokines (IL-8, CC chemokine ligand- CCL17). Furthermore, this WTCS cluster was associated with WTC exposure variables, ash at work, and the participant category workers; but not with the exposure variable WTC dust cloud at 9/11. A comparison of WTC exposure categorial variables identified that chemokines (CCL17, CCL11), circulating receptors (RAGE, TREM1), MMPs (MMP3, MMP12), and vascular markers (Angiogenin, vascular cell adhesion molecule-VCAM1) significantly increased in the more exposed groups. Circulating biomarkers of remodeling and inflammation identified clusters within WTCS and were associated with WTC exposure.

Suggested Citation

  • Gabriele Grunig & Nedim Durmus & Yian Zhang & Yuting Lu & Sultan Pehlivan & Yuyan Wang & Kathleen Doo & Maria L. Cotrina-Vidal & Roberta Goldring & Kenneth I. Berger & Mengling Liu & Yongzhao Shao & J, 2022. "Molecular Clustering Analysis of Blood Biomarkers in World Trade Center Exposed Community Members with Persistent Lower Respiratory Symptoms," IJERPH, MDPI, vol. 19(13), pages 1-18, July.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:13:p:8102-:d:853945
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    References listed on IDEAS

    as
    1. Yongzhao Shao & Nedim Durmus & Yian Zhang & Sultan Pehlivan & Maria-Elena Fernandez-Beros & Lisette Umana & Rachel Corona & Adrienne Addessi & Sharon A. Abbott & Sheila Smyth-Giambanco & Alan A. Arsla, 2021. "The Development of a WTC Environmental Health Center Pan-Cancer Database," IJERPH, MDPI, vol. 18(4), pages 1-18, February.
    2. Alan A. Arslan & Stephanie Tuminello & Lei Yang & Yian Zhang & Nedim Durmus & Matija Snuderl & Adriana Heguy & Anne Zeleniuch-Jacquotte & Yongzhao Shao & Joan Reibman, 2020. "Genome-Wide DNA Methylation Profiles in Community Members Exposed to the World Trade Center Disaster," IJERPH, MDPI, vol. 17(15), pages 1-13, July.
    3. Sophia Kwon & George Crowley & Mena Mikhail & Rachel Lam & Emily Clementi & Rachel Zeig-Owens & Theresa M. Schwartz & Mengling Liu & David J. Prezant & Anna Nolan, 2019. "Metabolic Syndrome Biomarkers of World Trade Center Airway Hyperreactivity: A 16-Year Prospective Cohort Study," IJERPH, MDPI, vol. 16(9), pages 1-14, April.
    4. Rebecca Rosen & Zhaoyin Zhu & Yongzhao Shao & Mengling Liu & Jia Bao & Nomi Levy-Carrick & Joan Reibman, 2019. "Longitudinal Change of PTSD Symptoms in Community Members after the World Trade Center Destruction," IJERPH, MDPI, vol. 16(7), pages 1-12, April.
    5. Alan A. Arslan & Yian Zhang & Nedim Durmus & Sultan Pehlivan & Adrienne Addessi & Freya Schnabel & Yongzhao Shao & Joan Reibman, 2021. "Breast Cancer Characteristics in the Population of Survivors Participating in the World Trade Center Environmental Health Center Program 2002–2019," IJERPH, MDPI, vol. 18(14), pages 1-11, July.
    6. Ridhwan Y. Baba & Yian Zhang & Yongzhao Shao & Kenneth I. Berger & Roberta M. Goldring & Mengling Liu & Angeliki Kazeros & Rebecca Rosen & Joan Reibman, 2022. "COPD in Smoking and Non-Smoking Community Members Exposed to the World Trade Center Dust and Fumes," IJERPH, MDPI, vol. 19(7), pages 1-12, April.
    7. Nedim Durmus & Sultan Pehlivan & Yian Zhang & Yongzhao Shao & Alan A. Arslan & Rachel Corona & Ian Henderson & Daniel H. Sterman & Joan Reibman, 2021. "Lung Cancer Characteristics in the World Trade Center Environmental Health Center," IJERPH, MDPI, vol. 18(5), pages 1-14, March.
    8. Miranda J. Spratlen & Frederica P. Perera & Andreas Sjodin & Yuyan Wang & Julie B. Herbstman & Leonardo Trasande, 2022. "Understanding the Role of Persistent Organic Pollutants and Stress in the Association between Proximity to the World Trade Center Disaster and Birth Outcomes," IJERPH, MDPI, vol. 19(4), pages 1-16, February.
    9. Rebecca Rosen & Yongzhao Shao & Qiao Zhang & Jia Bao & Yian Zhang & Arjun Masurkar & Thomas Wisniewski & Nina Urban & Joan Reibman, 2022. "Cognitive Function among World Trade Center-Exposed Community Members with Mental Health Symptoms," IJERPH, MDPI, vol. 19(6), pages 1-13, March.
    10. Rachel Lam & Syed H. Haider & George Crowley & Erin J. Caraher & Dean F. Ostrofsky & Angela Talusan & Sophia Kwon & David J. Prezant & Yuyan Wang & Mengling Liu & Anna Nolan, 2020. "Synergistic Effect of WTC-Particulate Matter and Lysophosphatidic Acid Exposure and the Role of RAGE: In-Vitro and Translational Assessment," IJERPH, MDPI, vol. 17(12), pages 1-22, June.
    11. Joan Reibman & Caralee Caplan-Shaw & Yinxiang Wu & Mengling Liu & Milan R. Amin & Kenneth I. Berger & Maria L. Cotrina-Vidal & Angeliki Kazeros & Nedim Durmus & Maria-Elena Fernandez-Beros & Roberta M, 2020. "Characterization of Persistent Uncontrolled Asthma Symptoms in Community Members Exposed to World Trade Center Dust and Fumes," IJERPH, MDPI, vol. 17(18), pages 1-17, September.
    12. Nedim Durmus & Yongzhao Shao & Alan A. Arslan & Yian Zhang & Sultan Pehlivan & Maria-Elena Fernandez-Beros & Lisette Umana & Rachel Corona & Sheila Smyth-Giambanco & Sharon A. Abbott & Joan Reibman, 2020. "Characteristics of Cancer Patients in the World Trade Center Environmental Health Center," IJERPH, MDPI, vol. 17(19), pages 1-15, October.
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