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Genome-Wide DNA Methylation Profiles in Community Members Exposed to the World Trade Center Disaster

Author

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  • Alan A. Arslan

    (Department of Obstetrics and Gynecology, New York University Langone Health, New York, NY 10016, USA
    Department of Population Health, New York University Langone Health, New York, NY 10016, USA
    NYU Perlmutter Comprehensive Cancer Center, New York, NY 10016, USA)

  • Stephanie Tuminello

    (Department of Population Health, New York University Langone Health, New York, NY 10016, USA)

  • Lei Yang

    (Department of Population Health, New York University Langone Health, New York, NY 10016, USA)

  • Yian Zhang

    (Department of Population Health, New York University Langone Health, New York, NY 10016, USA)

  • Nedim Durmus

    (Department of Medicine, New York University Langone Health, New York, NY 10016, USA)

  • Matija Snuderl

    (Department of Pathology, New York University Langone Health, New York, NY 10016, USA)

  • Adriana Heguy

    (Department of Pathology, New York University Langone Health, New York, NY 10016, USA
    NYU Langone’s Genome Technology Center, New York, NY 10016, USA)

  • Anne Zeleniuch-Jacquotte

    (Department of Population Health, New York University Langone Health, New York, NY 10016, USA
    NYU Perlmutter Comprehensive Cancer Center, New York, NY 10016, USA)

  • Yongzhao Shao

    (Department of Population Health, New York University Langone Health, New York, NY 10016, USA
    NYU Perlmutter Comprehensive Cancer Center, New York, NY 10016, USA)

  • Joan Reibman

    (Department of Medicine, New York University Langone Health, New York, NY 10016, USA)

Abstract

The primary goal of this pilot study was to assess feasibility of studies among local community members to address the hypothesis that complex exposures to the World Trade Center (WTC) dust and fumes resulted in long-term epigenetic changes. We enrolled 18 WTC-exposed cancer-free women from the WTC Environmental Health Center (WTC EHC) who agreed to donate blood samples during their standard clinical visits. As a reference WTC unexposed group, we randomly selected 24 age-matched cancer-free women from an existing prospective cohort who donated blood samples before 11 September 2001. The global DNA methylation analyses were performed using Illumina Infinium MethylationEpic arrays. Statistical analyses were performed using R Bioconductor package. Functional genomic analyses were done by mapping the top 5000 differentially expressed CpG sites to the Kyoto Encyclopedia of Genes and Genomes (KEGG) Pathway database. Among cancer-free subjects, we observed substantial methylation differences between WTC-exposed and unexposed women. The top 15 differentially methylated gene probes included BCAS2, OSGIN1, BMI1, EEF1A2, SPTBN5, CHD8, CDCA7L, AIDA, DDN, SNORD45C, ZFAND6, ARHGEF7, UBXN8, USF1, and USP12. Several cancer-related pathways were enriched in the WTC-exposed subjects, including endocytosis, mitogen-activated protein kinase (MAPK), viral carcinogenesis, as well as Ras-associated protein-1 (Rap1) and mammalian target of rapamycin (mTOR) signaling. The study provides preliminary data on substantial differences in DNA methylation between WTC-exposed and unexposed populations that require validation in further studies.

Suggested Citation

  • Alan A. Arslan & Stephanie Tuminello & Lei Yang & Yian Zhang & Nedim Durmus & Matija Snuderl & Adriana Heguy & Anne Zeleniuch-Jacquotte & Yongzhao Shao & Joan Reibman, 2020. "Genome-Wide DNA Methylation Profiles in Community Members Exposed to the World Trade Center Disaster," IJERPH, MDPI, vol. 17(15), pages 1-13, July.
  • Handle: RePEc:gam:jijerp:v:17:y:2020:i:15:p:5493-:d:391801
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    Citations

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    Cited by:

    1. Yongzhao Shao & Nedim Durmus & Yian Zhang & Sultan Pehlivan & Maria-Elena Fernandez-Beros & Lisette Umana & Rachel Corona & Adrienne Addessi & Sharon A. Abbott & Sheila Smyth-Giambanco & Alan A. Arsla, 2021. "The Development of a WTC Environmental Health Center Pan-Cancer Database," IJERPH, MDPI, vol. 18(4), pages 1-18, February.
    2. Gabriele Grunig & Nedim Durmus & Yian Zhang & Yuting Lu & Sultan Pehlivan & Yuyan Wang & Kathleen Doo & Maria L. Cotrina-Vidal & Roberta Goldring & Kenneth I. Berger & Mengling Liu & Yongzhao Shao & J, 2022. "Molecular Clustering Analysis of Blood Biomarkers in World Trade Center Exposed Community Members with Persistent Lower Respiratory Symptoms," IJERPH, MDPI, vol. 19(13), pages 1-18, July.
    3. Joan Reibman & Caralee Caplan-Shaw & Yinxiang Wu & Mengling Liu & Milan R. Amin & Kenneth I. Berger & Maria L. Cotrina-Vidal & Angeliki Kazeros & Nedim Durmus & Maria-Elena Fernandez-Beros & Roberta M, 2020. "Characterization of Persistent Uncontrolled Asthma Symptoms in Community Members Exposed to World Trade Center Dust and Fumes," IJERPH, MDPI, vol. 17(18), pages 1-17, September.
    4. Stephanie Tuminello & Yian Zhang & Lei Yang & Nedim Durmus & Matija Snuderl & Adriana Heguy & Anne Zeleniuch-Jacquotte & Yu Chen & Yongzhao Shao & Joan Reibman & Alan A. Arslan, 2022. "Global DNA Methylation Profiles in Peripheral Blood of WTC-Exposed Community Members with Breast Cancer," IJERPH, MDPI, vol. 19(9), pages 1-15, April.

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