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Genomics of Particulate Matter Exposure Associated Cardiopulmonary Disease: A Narrative Review

Author

Listed:
  • Julia Citron

    (Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, NYU, School of Medicine, New York, NY 10016, USA)

  • Emma Willcocks

    (Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, NYU, School of Medicine, New York, NY 10016, USA)

  • George Crowley

    (Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, NYU, School of Medicine, New York, NY 10016, USA)

  • Sophia Kwon

    (Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, NYU, School of Medicine, New York, NY 10016, USA)

  • Anna Nolan

    (Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, NYU, School of Medicine, New York, NY 10016, USA
    Department of Environmental Medicine, New York University, School of Medicine, New York, NY 10016, USA
    Bureau of Health Services, Fire Department of New York, Brooklyn, NY 11201, USA)

Abstract

Particulate matter (PM) exposure is associated with the development of cardiopulmonary disease. Our group has studied the adverse health effects of World Trade Center particulate matter (WTC-PM) exposure on firefighters. To fully understand the complex interplay between exposure, organism, and resultant disease phenotype, it is vital to analyze the underlying role of genomics in mediating this relationship. A PubMed search was performed focused on environmental exposure, genomics, and cardiopulmonary disease. We included original research published within 10 years, on epigenetic modifications and specific genetic or allelic variants. The initial search resulted in 95 studies. We excluded manuscripts that focused on work-related chemicals, heavy metals and tobacco smoke as primary sources of exposure, as well as reviews, prenatal research, and secondary research studies. Seven full-text articles met pre-determined inclusion criteria, and were reviewed. The effects of air pollution were evaluated in terms of methylation ( n = 3), oxidative stress ( n = 2), and genetic variants ( n = 2). There is evidence to suggest that genomics plays a meditating role in the formation of adverse cardiopulmonary symptoms and diseases that surface after exposure events. Genomic modifications and variations affect the association between environmental exposure and cardiopulmonary disease, but additional research is needed to further define this relationship.

Suggested Citation

  • Julia Citron & Emma Willcocks & George Crowley & Sophia Kwon & Anna Nolan, 2019. "Genomics of Particulate Matter Exposure Associated Cardiopulmonary Disease: A Narrative Review," IJERPH, MDPI, vol. 16(22), pages 1-11, November.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:22:p:4335-:d:284381
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    References listed on IDEAS

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    1. Sophia Kwon & George Crowley & Mena Mikhail & Rachel Lam & Emily Clementi & Rachel Zeig-Owens & Theresa M. Schwartz & Mengling Liu & David J. Prezant & Anna Nolan, 2019. "Metabolic Syndrome Biomarkers of World Trade Center Airway Hyperreactivity: A 16-Year Prospective Cohort Study," IJERPH, MDPI, vol. 16(9), pages 1-14, April.
    2. Krystal L. Cleven & Kenny Ye & Rachel Zeig-Owens & Kerry M. Hena & Cristina Montagna & Jidong Shan & H. Dean Hosgood & Nadia Jaber & Michael D. Weiden & Hilary L. Colbeth & David G. Goldfarb & Simon D, 2019. "Genetic Variants Associated with FDNY WTC-Related Sarcoidosis," IJERPH, MDPI, vol. 16(10), pages 1-10, May.
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    Cited by:

    1. Joan Reibman & Caralee Caplan-Shaw & Yinxiang Wu & Mengling Liu & Milan R. Amin & Kenneth I. Berger & Maria L. Cotrina-Vidal & Angeliki Kazeros & Nedim Durmus & Maria-Elena Fernandez-Beros & Roberta M, 2020. "Characterization of Persistent Uncontrolled Asthma Symptoms in Community Members Exposed to World Trade Center Dust and Fumes," IJERPH, MDPI, vol. 17(18), pages 1-17, September.

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