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The Development of a WTC Environmental Health Center Pan-Cancer Database

Author

Listed:
  • Yongzhao Shao

    (Division of Biostatistics, Department of Population Health, NYU Grossman School of Medicine (NYUGSOM), New York University, New York, NY 10016, USA
    Department of Environmental Medicine, NYUG-SOM, New York University, New York, NY 10016, USA
    World Trade Center Environmental Health Center, NYC Health + Hospitals, New York, NY 10016, USA
    NYU Perlmutter Comprehensive Cancer Center, New York, NY 10016, USA)

  • Nedim Durmus

    (World Trade Center Environmental Health Center, NYC Health + Hospitals, New York, NY 10016, USA
    Division of Pulmonary Medicine, School of Medicine (SOM), NYUG-SOM, New York University, New York, NY 10016, USA)

  • Yian Zhang

    (Division of Biostatistics, Department of Population Health, NYU Grossman School of Medicine (NYUGSOM), New York University, New York, NY 10016, USA
    World Trade Center Environmental Health Center, NYC Health + Hospitals, New York, NY 10016, USA)

  • Sultan Pehlivan

    (World Trade Center Environmental Health Center, NYC Health + Hospitals, New York, NY 10016, USA
    Division of Pulmonary Medicine, School of Medicine (SOM), NYUG-SOM, New York University, New York, NY 10016, USA)

  • Maria-Elena Fernandez-Beros

    (World Trade Center Environmental Health Center, NYC Health + Hospitals, New York, NY 10016, USA
    Division of Pulmonary Medicine, School of Medicine (SOM), NYUG-SOM, New York University, New York, NY 10016, USA)

  • Lisette Umana

    (World Trade Center Environmental Health Center, NYC Health + Hospitals, New York, NY 10016, USA
    Division of Pulmonary Medicine, School of Medicine (SOM), NYUG-SOM, New York University, New York, NY 10016, USA)

  • Rachel Corona

    (World Trade Center Environmental Health Center, NYC Health + Hospitals, New York, NY 10016, USA
    Division of Pulmonary Medicine, School of Medicine (SOM), NYUG-SOM, New York University, New York, NY 10016, USA)

  • Adrienne Addessi

    (World Trade Center Environmental Health Center, NYC Health + Hospitals, New York, NY 10016, USA)

  • Sharon A. Abbott

    (World Trade Center Environmental Health Center, NYC Health + Hospitals, New York, NY 10016, USA)

  • Sheila Smyth-Giambanco

    (World Trade Center Environmental Health Center, NYC Health + Hospitals, New York, NY 10016, USA)

  • Alan A. Arslan

    (Division of Biostatistics, Department of Population Health, NYU Grossman School of Medicine (NYUGSOM), New York University, New York, NY 10016, USA
    Department of Environmental Medicine, NYUG-SOM, New York University, New York, NY 10016, USA
    World Trade Center Environmental Health Center, NYC Health + Hospitals, New York, NY 10016, USA
    NYU Perlmutter Comprehensive Cancer Center, New York, NY 10016, USA)

  • Joan Reibman

    (Department of Environmental Medicine, NYUG-SOM, New York University, New York, NY 10016, USA
    World Trade Center Environmental Health Center, NYC Health + Hospitals, New York, NY 10016, USA
    Division of Pulmonary Medicine, School of Medicine (SOM), NYUG-SOM, New York University, New York, NY 10016, USA)

Abstract

(1) Background: Recent studies have reported elevated risks of multiple cancers in the World Trade Center (WTC) affected community members (also called WTC “Survivors”). The large variety of WTC-cancers created a need to develop a comprehensive cancer database. This paper describes the development of a pan-cancer database at the WTC Environmental Health Center (EHC) Data Center. (2) Methods: A new REDCap-based pan-cancer database was created using the pathology reports and available biomarker data of confirmed cancer cases after review by a cancer epidemiologist, a pathologist, physicians and biostatisticians. (3) Results: The WTC EHC pan-cancer database contains cancer characteristics and emerging biomarker information for cancers of individuals enrolled in the WTC EHC and diagnosed after 11 September 2001 and up to 31 December 2019 obtained from WTC EHC clinical records, pathological reports and state cancer registries. As of 31 December 2019, the database included 3440 cancer cases with cancer characteristics and biomarker information. (4) Conclusions: This evolving database represents an important resource for the scientific community facilitating future research about the etiology, heterogeneity, characteristics and outcomes of cancers and comorbid mental health conditions, cancer economics and gene–environment interaction in the unique population of WTC survivors.

Suggested Citation

  • Yongzhao Shao & Nedim Durmus & Yian Zhang & Sultan Pehlivan & Maria-Elena Fernandez-Beros & Lisette Umana & Rachel Corona & Adrienne Addessi & Sharon A. Abbott & Sheila Smyth-Giambanco & Alan A. Arsla, 2021. "The Development of a WTC Environmental Health Center Pan-Cancer Database," IJERPH, MDPI, vol. 18(4), pages 1-18, February.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:4:p:1646-:d:496265
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    References listed on IDEAS

    as
    1. Alan A. Arslan & Stephanie Tuminello & Lei Yang & Yian Zhang & Nedim Durmus & Matija Snuderl & Adriana Heguy & Anne Zeleniuch-Jacquotte & Yongzhao Shao & Joan Reibman, 2020. "Genome-Wide DNA Methylation Profiles in Community Members Exposed to the World Trade Center Disaster," IJERPH, MDPI, vol. 17(15), pages 1-13, July.
    2. Rebecca Rosen & Zhaoyin Zhu & Yongzhao Shao & Mengling Liu & Jia Bao & Nomi Levy-Carrick & Joan Reibman, 2019. "Longitudinal Change of PTSD Symptoms in Community Members after the World Trade Center Destruction," IJERPH, MDPI, vol. 16(7), pages 1-12, April.
    3. Sujata Thawani & Bin Wang & Yongzhao Shao & Joan Reibman & Michael Marmor, 2019. "Time to Onset of Paresthesia Among Community Members Exposed to the World Trade Center Disaster," IJERPH, MDPI, vol. 16(8), pages 1-11, April.
    4. Maslow, C.B. & Friedman, S.M. & Pillai, P.S. & Reibman, J. & Berger, K.I. & Goldring, R. & Stellman, S.D. & Farfel, M., 2012. "Chronic and acute exposures to the world trade center disaster and lower respiratory symptoms: Area residents and workers," American Journal of Public Health, American Public Health Association, vol. 102(6), pages 1186-1194.
    5. Yongzhao Shao & Yian Zhang & Mengling Liu & Maria-Elena Fernandez-Beros & Meng Qian & Joan Reibman, 2020. "Gene-Environment Interaction between the IL1RN Variants and Childhood Environmental Tobacco Smoke Exposure in Asthma Risk," IJERPH, MDPI, vol. 17(6), pages 1-16, March.
    6. Paru Patrawalla & Angeliki Kazeros & Linda Rogers & Yongzhao Shao & Mengling Liu & Maria-Elena Fernandez-Beros & Shulian Shang & Joan Reibman, 2012. "Application of the Asthma Phenotype Algorithm from the Severe Asthma Research Program to an Urban Population," PLOS ONE, Public Library of Science, vol. 7(9), pages 1-7, September.
    7. Nedim Durmus & Yongzhao Shao & Alan A. Arslan & Yian Zhang & Sultan Pehlivan & Maria-Elena Fernandez-Beros & Lisette Umana & Rachel Corona & Sheila Smyth-Giambanco & Sharon A. Abbott & Joan Reibman, 2020. "Characteristics of Cancer Patients in the World Trade Center Environmental Health Center," IJERPH, MDPI, vol. 17(19), pages 1-15, October.
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    Cited by:

    1. Rebecca Lynn Florsheim & Qiao Zhang & Nedim Durmus & Yian Zhang & Sultan Pehlivan & Alan A. Arslan & Yongzhao Shao & Joan Reibman, 2022. "Characteristics of Cancers in Community Members Exposed to the World Trade Center Disaster at a Young Age," IJERPH, MDPI, vol. 19(22), pages 1-17, November.
    2. Yian Zhang & Rebecca Rosen & Joan Reibman & Yongzhao Shao, 2022. "Posttraumatic Stress Disorder Mediates the Association between Traumatic World Trade Center Dust Cloud Exposure and Ongoing Systemic Inflammation in Community Members," IJERPH, MDPI, vol. 19(14), pages 1-16, July.
    3. James E. Cone & Albeliz Santiago-Colón & Roberto Lucchini, 2021. "9/11 Health Update," IJERPH, MDPI, vol. 18(12), pages 1-5, June.
    4. Alan A. Arslan & Yian Zhang & Nedim Durmus & Sultan Pehlivan & Adrienne Addessi & Freya Schnabel & Yongzhao Shao & Joan Reibman, 2021. "Breast Cancer Characteristics in the Population of Survivors Participating in the World Trade Center Environmental Health Center Program 2002–2019," IJERPH, MDPI, vol. 18(14), pages 1-11, July.
    5. Nedim Durmus & Sultan Pehlivan & Yian Zhang & Yongzhao Shao & Alan A. Arslan & Rachel Corona & Ian Henderson & Daniel H. Sterman & Joan Reibman, 2021. "Lung Cancer Characteristics in the World Trade Center Environmental Health Center," IJERPH, MDPI, vol. 18(5), pages 1-14, March.
    6. Rebecca Rosen & Yongzhao Shao & Qiao Zhang & Jia Bao & Yian Zhang & Arjun Masurkar & Thomas Wisniewski & Nina Urban & Joan Reibman, 2022. "Cognitive Function among World Trade Center-Exposed Community Members with Mental Health Symptoms," IJERPH, MDPI, vol. 19(6), pages 1-13, March.
    7. Gabriele Grunig & Nedim Durmus & Yian Zhang & Yuting Lu & Sultan Pehlivan & Yuyan Wang & Kathleen Doo & Maria L. Cotrina-Vidal & Roberta Goldring & Kenneth I. Berger & Mengling Liu & Yongzhao Shao & J, 2022. "Molecular Clustering Analysis of Blood Biomarkers in World Trade Center Exposed Community Members with Persistent Lower Respiratory Symptoms," IJERPH, MDPI, vol. 19(13), pages 1-18, July.
    8. Stephanie Tuminello & Yian Zhang & Lei Yang & Nedim Durmus & Matija Snuderl & Adriana Heguy & Anne Zeleniuch-Jacquotte & Yu Chen & Yongzhao Shao & Joan Reibman & Alan A. Arslan, 2022. "Global DNA Methylation Profiles in Peripheral Blood of WTC-Exposed Community Members with Breast Cancer," IJERPH, MDPI, vol. 19(9), pages 1-15, April.
    9. Elaine Shum & Nedim Durmus & Sultan Pehlivan & Yuting Lu & Yian Zhang & Alan A. Arslan & Yongzhao Shao & Joan Reibman, 2022. "Characteristics of Women with Lung Adenocarcinoma in the World Trade Center Environmental Health Center," IJERPH, MDPI, vol. 19(13), pages 1-10, June.

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