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Food Intake REstriction for Health OUtcome Support and Education (FIREHOUSE) Protocol: A Randomized Clinical Trial

Author

Listed:
  • Sophia Kwon

    (Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, School of Medicine, New York University, New York, NY 10016, USA
    Contributed equally.)

  • Jessica Riggs

    (Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, School of Medicine, New York University, New York, NY 10016, USA
    Contributed equally.)

  • George Crowley

    (Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, School of Medicine, New York University, New York, NY 10016, USA)

  • Rachel Lam

    (Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, School of Medicine, New York University, New York, NY 10016, USA)

  • Isabel R. Young

    (Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, School of Medicine, New York University, New York, NY 10016, USA)

  • Christine Nayar

    (Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, School of Medicine, New York University, New York, NY 10016, USA)

  • Maria Sunseri

    (Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, School of Medicine, New York University, New York, NY 10016, USA)

  • Mena Mikhail

    (Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, School of Medicine, New York University, New York, NY 10016, USA)

  • Dean Ostrofsky

    (Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, School of Medicine, New York University, New York, NY 10016, USA)

  • Arul Veerappan

    (Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, School of Medicine, New York University, New York, NY 10016, USA)

  • Rachel Zeig-Owens

    (Bureau of Health Services and Office of Medical Affairs, Fire Department of New York, Brooklyn, NY 11201, USA
    Pulmonary Medicine Division, Department of Medicine, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, NY 10461, USA)

  • Theresa Schwartz

    (Bureau of Health Services and Office of Medical Affairs, Fire Department of New York, Brooklyn, NY 11201, USA)

  • Hilary Colbeth

    (Bureau of Health Services and Office of Medical Affairs, Fire Department of New York, Brooklyn, NY 11201, USA)

  • Mengling Liu

    (Department of Population Health, Division of Biostatistics, New York University School of Medicine, New York, NY 10016, USA
    Department of Environmental Medicine, School of Medicine, New York University, New York, NY 10016, USA)

  • Mary Lou Pompeii

    (Department of Population Health, Division of Health and Behavior, Center for Healthful Behavior Change, School of Medicine, New York University, New York, NY 10016, USA)

  • David St-Jules

    (Department of Population Health, Division of Health and Behavior, Center for Healthful Behavior Change, School of Medicine, New York University, New York, NY 10016, USA)

  • David J. Prezant

    (Bureau of Health Services and Office of Medical Affairs, Fire Department of New York, Brooklyn, NY 11201, USA
    Pulmonary Medicine Division, Department of Medicine, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, NY 10461, USA)

  • Mary Ann Sevick

    (Department of Population Health, Division of Health and Behavior, Center for Healthful Behavior Change, School of Medicine, New York University, New York, NY 10016, USA
    Departments of Medicine, Division of Endocrinology, School of Medicine, New York University, New York, NY 10016, USA)

  • Anna Nolan

    (Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, School of Medicine, New York University, New York, NY 10016, USA
    Bureau of Health Services and Office of Medical Affairs, Fire Department of New York, Brooklyn, NY 11201, USA
    Department of Environmental Medicine, School of Medicine, New York University, New York, NY 10016, USA)

Abstract

Fire Department of New York (FDNY) rescue and recovery workers exposed to World Trade Center (WTC) particulates suffered loss of forced expiratory volume in 1 s (FEV 1 ). Metabolic Syndrome increased the risk of developing WTC-lung injury (WTC-LI) . We aim to attenuate the deleterious effects of WTC exposure through a dietary intervention targeting these clinically relevant disease modifiers. We hypothesize that a calorie-restricted Mediterranean dietary intervention will improve metabolic risk, subclinical indicators of cardiopulmonary disease, quality of life, and lung function in firefighters with WTC-LI. To assess our hypothesis, we developed the Food Intake REstriction for Health OUtcome Support and Education (FIREHOUSE), a randomized controlled clinical trial (RCT). Male firefighters with WTC-LI and a BMI > 27 kg/m 2 will be included. We will randomize subjects (1:1) to either: (1) Low Calorie Mediterranean (LoCalMed)—an integrative multifactorial, technology-supported approach focused on behavioral modification, nutritional education that will include a self-monitored diet with feedback, physical activity recommendations, and social cognitive theory-based group counseling sessions; or (2) Usual Care. Outcomes include reduction in body mass index (BMI) (primary), improvement in FEV 1 , fractional exhaled nitric oxide, pulse wave velocity, lipid profiles, targeted metabolic/clinical biomarkers, and quality of life measures (secondary). By implementing a technology-supported LoCalMed diet our FIREHOUSE RCT may help further the treatment of WTC associated pulmonary disease.

Suggested Citation

  • Sophia Kwon & Jessica Riggs & George Crowley & Rachel Lam & Isabel R. Young & Christine Nayar & Maria Sunseri & Mena Mikhail & Dean Ostrofsky & Arul Veerappan & Rachel Zeig-Owens & Theresa Schwartz & , 2020. "Food Intake REstriction for Health OUtcome Support and Education (FIREHOUSE) Protocol: A Randomized Clinical Trial," IJERPH, MDPI, vol. 17(18), pages 1-15, September.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:18:p:6569-:d:411164
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    References listed on IDEAS

    as
    1. Sophia Kwon & George Crowley & Mena Mikhail & Rachel Lam & Emily Clementi & Rachel Zeig-Owens & Theresa M. Schwartz & Mengling Liu & David J. Prezant & Anna Nolan, 2019. "Metabolic Syndrome Biomarkers of World Trade Center Airway Hyperreactivity: A 16-Year Prospective Cohort Study," IJERPH, MDPI, vol. 16(9), pages 1-14, April.
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    Cited by:

    1. James E. Cone & Albeliz Santiago-Colón & Roberto Lucchini, 2021. "9/11 Health Update," IJERPH, MDPI, vol. 18(12), pages 1-5, June.

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