IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v18y2020i1p184-d469879.html
   My bibliography  Save this article

Sex and Exposure to Postnatal Chlorpyrifos Influence the Epigenetics of Feeding-Related Genes in a Transgenic APOE Mouse Model: Long-Term Implications on Body Weight after a High-Fat Diet

Author

Listed:
  • Laia Guardia-Escote

    (Research in Neurobehavior and Health (NEUROLAB), Universitat Rovira i Virgili, 43007 Tarragona, Spain
    Department of Psychology and Research Center for Behavior Assessment (CRAMC), Universitat Rovira i Virgili, Campus Sescelades, 43007 Tarragona, Spain
    Laboratory of Toxicology and Environmental Health, School of Medicine, IISPV, Universitat Rovira i Virgili, 43201 Reus, Spain)

  • Jordi Blanco

    (Research in Neurobehavior and Health (NEUROLAB), Universitat Rovira i Virgili, 43007 Tarragona, Spain
    Laboratory of Toxicology and Environmental Health, School of Medicine, IISPV, Universitat Rovira i Virgili, 43201 Reus, Spain
    Department of Basic Medical Sciences, Universitat Rovira i Virgili, 43201 Reus, Spain)

  • Pia Basaure

    (Research in Neurobehavior and Health (NEUROLAB), Universitat Rovira i Virgili, 43007 Tarragona, Spain)

  • Judit Biosca-Brull

    (Research in Neurobehavior and Health (NEUROLAB), Universitat Rovira i Virgili, 43007 Tarragona, Spain
    Department of Psychology and Research Center for Behavior Assessment (CRAMC), Universitat Rovira i Virgili, Campus Sescelades, 43007 Tarragona, Spain
    Laboratory of Toxicology and Environmental Health, School of Medicine, IISPV, Universitat Rovira i Virgili, 43201 Reus, Spain)

  • Rikst Nynke Verkaik-Schakel

    (Department of Obstetrics and Gynecology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands)

  • Maria Cabré

    (Research in Neurobehavior and Health (NEUROLAB), Universitat Rovira i Virgili, 43007 Tarragona, Spain
    Department of Biochemistry and Biotechnology, Universitat Rovira i Virgili, 43007 Tarragona, Spain)

  • Fiona Peris-Sampedro

    (Department of Physiology/Endocrinology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, 405 30 Gothenburg, Sweden)

  • Cristian Pérez-Fernández

    (Department of Psychology and Health Research Center (CEINSA), Almeria University-ceiA3, 04120 Almeria, Spain)

  • Fernando Sánchez-Santed

    (Department of Psychology and Health Research Center (CEINSA), Almeria University-ceiA3, 04120 Almeria, Spain)

  • Torsten Plösch

    (Department of Obstetrics and Gynecology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands)

  • José L. Domingo

    (Laboratory of Toxicology and Environmental Health, School of Medicine, IISPV, Universitat Rovira i Virgili, 43201 Reus, Spain
    Department of Basic Medical Sciences, Universitat Rovira i Virgili, 43201 Reus, Spain)

  • Maria Teresa Colomina

    (Research in Neurobehavior and Health (NEUROLAB), Universitat Rovira i Virgili, 43007 Tarragona, Spain
    Department of Psychology and Research Center for Behavior Assessment (CRAMC), Universitat Rovira i Virgili, Campus Sescelades, 43007 Tarragona, Spain
    Laboratory of Toxicology and Environmental Health, School of Medicine, IISPV, Universitat Rovira i Virgili, 43201 Reus, Spain)

Abstract

Developmental exposure to toxicants and diet can interact with an individual’s genetics and produce long-lasting metabolic adaptations. The different isoforms of the apolipoprotein E ( APOE ) are an important source of variability in metabolic disorders and influence the response to the pesticide chlorpyrifos (CPF). We aimed to study the epigenetic regulation on feeding control genes and the influence of postnatal CPF exposure, APOE genotype, and sex, and how these modifications impact on the metabolic response to a high-fat diet (HFD). Both male and female apoE3- and apoE4-TR mice were exposed to CPF on postnatal days 10–15. The DNA methylation pattern of proopiomelanocortin, neuropeptide Y, leptin receptor, and insulin-like growth factor 2 was studied in the hypothalamus. At adulthood, the mice were given a HFD for eight weeks. The results highlight the importance of sex in the epigenetic regulation and the implication of CPF treatment and APOE genotype. The body weight progression exhibited sex-dimorphic differences, apoE4-TR males being the most susceptible to the effects induced by CPF and HFD. Overall, these results underscore the pivotal role of sex, APOE genotype, and developmental exposure to CPF on subsequent metabolic disturbances later in life and show that sex is a key variable in epigenetic regulation.

Suggested Citation

  • Laia Guardia-Escote & Jordi Blanco & Pia Basaure & Judit Biosca-Brull & Rikst Nynke Verkaik-Schakel & Maria Cabré & Fiona Peris-Sampedro & Cristian Pérez-Fernández & Fernando Sánchez-Santed & Torsten , 2020. "Sex and Exposure to Postnatal Chlorpyrifos Influence the Epigenetics of Feeding-Related Genes in a Transgenic APOE Mouse Model: Long-Term Implications on Body Weight after a High-Fat Diet," IJERPH, MDPI, vol. 18(1), pages 1-17, December.
    • Handle: RePEc:gam:jijerp:v:18:y:2020:i:1:p:184-:d:469879
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/18/1/184/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/18/1/184/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Michael W. Schwartz & Stephen C. Woods & Daniel Porte & Randy J. Seeley & Denis G. Baskin, 2000. "Central nervous system control of food intake," Nature, Nature, vol. 404(6778), pages 661-671, April.
    2. Dhiraj G. Kabra & Katrin Pfuhlmann & Cristina García-Cáceres & Sonja C. Schriever & Veronica Casquero García & Adam Fiseha Kebede & Esther Fuente-Martin & Chitrang Trivedi & Kristy Heppner & N. Henrie, 2016. "Hypothalamic leptin action is mediated by histone deacetylase 5," Nature Communications, Nature, vol. 7(1), pages 1-12, April.
    3. G. J. Morton & D. E. Cummings & D. G. Baskin & G. S. Barsh & M. W. Schwartz, 2006. "Central nervous system control of food intake and body weight," Nature, Nature, vol. 443(7109), pages 289-295, September.
    4. Alexander M. Herman & Joshua Ortiz-Guzman & Mikhail Kochukov & Isabella Herman & Kathleen B. Quast & Jay M. Patel & Burak Tepe & Jeffrey C. Carlson & Kevin Ung & Jennifer Selever & Qingchun Tong & Ben, 2016. "A cholinergic basal forebrain feeding circuit modulates appetite suppression," Nature, Nature, vol. 538(7624), pages 253-256, October.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Yanine, Franco Fernando & Caballero, Federico I. & Sauma, Enzo E. & Córdova, Felisa M., 2014. "Building sustainable energy systems: Homeostatic control of grid-connected microgrids, as a means to reconcile power supply and energy demand response management," Renewable and Sustainable Energy Reviews, Elsevier, vol. 40(C), pages 1168-1191.
    2. Trenton Smith, 2009. "Reconciling psychology with economics: Obesity, behavioral biology, and rational overeating," Journal of Bioeconomics, Springer, vol. 11(3), pages 249-282, December.
    3. Yi Huang & Anyongqi Wang & Wenjiang Zhou & Baoguo Li & Linshan Zhang & Agata M. Rudolf & Zengguang Jin & Catherine Hambly & Guanlin Wang & John R. Speakman, 2024. "Maternal dietary fat during lactation shapes single nucleus transcriptomic profile of postnatal offspring hypothalamus in a sexually dimorphic manner in mice," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    4. Nathan Fearby & Samantha Penman & Panayotis Thanos, 2022. "Effects of Δ9-Tetrahydrocannibinol (THC) on Obesity at Different Stages of Life: A Literature Review," IJERPH, MDPI, vol. 19(6), pages 1-28, March.
    5. Mingming Xing & Yang Li & Yuqi Zhang & Juemou Zhou & Danting Ma & Mengqi Zhang & Minglei Tang & Ting Ouyang & Fumiao Zhang & Xiaofeng Shi & Jianyuan Sun & Zuxin Chen & Weiping J. Zhang & Shuli Zhang &, 2024. "Paraventricular hypothalamic RUVBL2 neurons suppress appetite by enhancing excitatory synaptic transmission in distinct neurocircuits," Nature Communications, Nature, vol. 15(1), pages 1-21, December.
    6. Hui Chen & David Simar & Margaret J Morris, 2009. "Hypothalamic Neuroendocrine Circuitry is Programmed by Maternal Obesity: Interaction with Postnatal Nutritional Environment," PLOS ONE, Public Library of Science, vol. 4(7), pages 1-10, July.
    7. Smith, Trenton G, 2002. "Obesity and Nature's Thumbprint: How Modern Waistlines Can Inform Economic Theory," University of California at Santa Barbara, Economics Working Paper Series qt31g1m028, Department of Economics, UC Santa Barbara.
    8. Brad Shuck & Joy L. Hart & Kandi L. Walker & Jayesh Rai & Shweta Srivastava & Sanjay Srivastava & Shesh Rai & Aruni Bhatnagar & Rachel J. Keith, 2022. "Workplace Culture and Biomarkers of Health Risk," IJERPH, MDPI, vol. 19(19), pages 1-18, September.
    9. Yanyi Li & Jiabo Zhang, 2020. "The Effect of Acute Erythromycin Exposure on the Swimming Ability of Zebrafish ( Danio rerio ) and Medaka ( Oryzias latipes )," IJERPH, MDPI, vol. 17(10), pages 1-16, May.
    10. Alex M Gavrila & Suzanne Hood & Barry Robinson & Shimon Amir, 2017. "Effects of bilateral anterior agranular insula lesions on food anticipatory activity in rats," PLOS ONE, Public Library of Science, vol. 12(6), pages 1-21, June.
    11. Gregorini, Pablo & Beukes, Pierre C. & Romera, Alvaro J. & Levy, Gil & Hanigan, Mark D., 2013. "A model of diurnal grazing patterns and herbage intake of a dairy cow, MINDY: Model description," Ecological Modelling, Elsevier, vol. 270(C), pages 11-29.
    12. Franklin Amuakwa-Mensah & George Marbuah & Mwenya Mubanga, 2016. "Climate variability and infectious diseases nexus: evidence from Sweden," Working Papers 2016.02, FAERE - French Association of Environmental and Resource Economists.
    13. Yunpo Zhao & Mohammed A. Khallaf & Emilia Johansson & Najat Dzaki & Shreelatha Bhat & Johannes Alfredsson & Jianli Duan & Bill S. Hansson & Markus Knaden & Mattias Alenius, 2022. "Hedgehog-mediated gut-taste neuron axis controls sweet perception in Drosophila," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    14. Sheng Qiu & Qinan Wu & Hao Wang & Dongfang Liu & Chen Chen & Zhiming Zhu & Hongting Zheng & Gangyi Yang & Ling Li & Mengliu Yang, 2024. "AZGP1 in POMC neurons modulates energy homeostasis and metabolism through leptin-mediated STAT3 phosphorylation," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    15. Baohua Jing & Qing Yang & Weidong Xin & Luo Xu, 2019. "The Nesfatin-1 Pathway from Hippocampus to Ventromedial Nucleus and its Regulation on Gastric Motility in Diabetic Rat," International Journal of Sciences, Office ijSciences, vol. 8(02), pages 20-24, February.
    16. Jessica Schwarz & Jasmine Burguet & Olivier Rampin & Gilles Fromentin & Philippe Andrey & Daniel Tomé & Yves Maurin & Nicolas Darcel, 2010. "Three-Dimensional Macronutrient-Associated Fos Expression Patterns in the Mouse Brainstem," PLOS ONE, Public Library of Science, vol. 5(2), pages 1-8, February.
    17. Stéphane Leon & Vincent Simon & Thomas H. Lee & Lukas Steuernagel & Samantha Clark & Nasim Biglari & Thierry Lesté-Lasserre & Nathalie Dupuy & Astrid Cannich & Luigi Bellocchio & Philippe Zizzari & Ca, 2024. "Single cell tracing of Pomc neurons reveals recruitment of ‘Ghost’ subtypes with atypical identity in a mouse model of obesity," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    18. Miharu Tamaoki & Ikumi Honda & Keisuke Nakanishi & Maki Nakajima & Sophathya Cheam & Manabu Okawada & Hisataka Sakakibara, 2022. "Lifestyle Factors Associated with Metabolic Syndrome in Urban Cambodia," IJERPH, MDPI, vol. 19(17), pages 1-11, August.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:18:y:2020:i:1:p:184-:d:469879. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.