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Central nervous system control of food intake

Author

Listed:
  • Michael W. Schwartz

    (Harborview Medical Center and VA Puget Sound Health Care System, University of Washington)

  • Stephen C. Woods

    (University of Cincinnati)

  • Daniel Porte

    (Harborview Medical Center and VA Puget Sound Health Care System, University of Washington)

  • Randy J. Seeley

    (University of Cincinnati)

  • Denis G. Baskin

    (Harborview Medical Center and VA Puget Sound Health Care System, University of Washington
    University of Washington)

Abstract

New information regarding neuronal circuits that control food intake and their hormonal regulation has extended our understanding of energy homeostasis, the process whereby energy intake is matched to energy expenditure over time. The profound obesity that results in rodents (and in the rare human case as well) from mutation of key signalling molecules involved in this regulatory system highlights its importance to human health. Although each new signalling pathway discovered in the hypothalamus is a potential target for drug development in the treatment of obesity, the growing number of such signalling molecules indicates that food intake is controlled by a highly complex process. To better understand how energy homeostasis can be achieved, we describe a model that delineates the roles of individual hormonal and neuropeptide signalling pathways in the control of food intake and the means by which obesity can arise from inherited or acquired defects in their function.

Suggested Citation

  • Michael W. Schwartz & Stephen C. Woods & Daniel Porte & Randy J. Seeley & Denis G. Baskin, 2000. "Central nervous system control of food intake," Nature, Nature, vol. 404(6778), pages 661-671, April.
    • Handle: RePEc:nat:nature:v:404:y:2000:i:6778:d:10.1038_35007534
    DOI: 10.1038/35007534
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    Cited by:

    1. Yi Huang & Anyongqi Wang & Wenjiang Zhou & Baoguo Li & Linshan Zhang & Agata M. Rudolf & Zengguang Jin & Catherine Hambly & Guanlin Wang & John R. Speakman, 2024. "Maternal dietary fat during lactation shapes single nucleus transcriptomic profile of postnatal offspring hypothalamus in a sexually dimorphic manner in mice," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. Franklin Amuakwa-Mensah & George Marbuah & Mwenya Mubanga, 2016. "Climate variability and infectious diseases nexus: evidence from Sweden," Working Papers 2016.02, FAERE - French Association of Environmental and Resource Economists.
    3. Jessica Schwarz & Jasmine Burguet & Olivier Rampin & Gilles Fromentin & Philippe Andrey & Daniel Tomé & Yves Maurin & Nicolas Darcel, 2010. "Three-Dimensional Macronutrient-Associated Fos Expression Patterns in the Mouse Brainstem," PLOS ONE, Public Library of Science, vol. 5(2), pages 1-8, February.
    4. Hui Chen & David Simar & Margaret J Morris, 2009. "Hypothalamic Neuroendocrine Circuitry is Programmed by Maternal Obesity: Interaction with Postnatal Nutritional Environment," PLOS ONE, Public Library of Science, vol. 4(7), pages 1-10, July.
    5. Laia Guardia-Escote & Jordi Blanco & Pia Basaure & Judit Biosca-Brull & Rikst Nynke Verkaik-Schakel & Maria Cabré & Fiona Peris-Sampedro & Cristian Pérez-Fernández & Fernando Sánchez-Santed & Torsten , 2020. "Sex and Exposure to Postnatal Chlorpyrifos Influence the Epigenetics of Feeding-Related Genes in a Transgenic APOE Mouse Model: Long-Term Implications on Body Weight after a High-Fat Diet," IJERPH, MDPI, vol. 18(1), pages 1-17, December.
    6. Trenton Smith, 2009. "Reconciling psychology with economics: Obesity, behavioral biology, and rational overeating," Journal of Bioeconomics, Springer, vol. 11(3), pages 249-282, December.
    7. Yanine, Franco Fernando & Caballero, Federico I. & Sauma, Enzo E. & Córdova, Felisa M., 2014. "Building sustainable energy systems: Homeostatic control of grid-connected microgrids, as a means to reconcile power supply and energy demand response management," Renewable and Sustainable Energy Reviews, Elsevier, vol. 40(C), pages 1168-1191.
    8. Baohua Jing & Qing Yang & Weidong Xin & Luo Xu, 2019. "The Nesfatin-1 Pathway from Hippocampus to Ventromedial Nucleus and its Regulation on Gastric Motility in Diabetic Rat," International Journal of Sciences, Office ijSciences, vol. 8(02), pages 20-24, February.
    9. Smith, Trenton G, 2002. "Obesity and Nature's Thumbprint: How Modern Waistlines Can Inform Economic Theory," University of California at Santa Barbara, Economics Working Paper Series qt31g1m028, Department of Economics, UC Santa Barbara.
    10. Brad Shuck & Joy L. Hart & Kandi L. Walker & Jayesh Rai & Shweta Srivastava & Sanjay Srivastava & Shesh Rai & Aruni Bhatnagar & Rachel J. Keith, 2022. "Workplace Culture and Biomarkers of Health Risk," IJERPH, MDPI, vol. 19(19), pages 1-18, September.
    11. Yanyi Li & Jiabo Zhang, 2020. "The Effect of Acute Erythromycin Exposure on the Swimming Ability of Zebrafish ( Danio rerio ) and Medaka ( Oryzias latipes )," IJERPH, MDPI, vol. 17(10), pages 1-16, May.
    12. Alex M Gavrila & Suzanne Hood & Barry Robinson & Shimon Amir, 2017. "Effects of bilateral anterior agranular insula lesions on food anticipatory activity in rats," PLOS ONE, Public Library of Science, vol. 12(6), pages 1-21, June.

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