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Central nervous system control of food intake and body weight

Author

Listed:
  • G. J. Morton

    (Harborview Medical Center and University of Washington)

  • D. E. Cummings

    (Veterans Affairs Puget Sound Health Care System and University of Washington)

  • D. G. Baskin

    (Veterans Affairs Puget Sound Health Care System and University of Washington
    University of Washington)

  • G. S. Barsh

    (Stanford University School of Medicine)

  • M. W. Schwartz

    (Harborview Medical Center and University of Washington)

Abstract

The capacity to adjust food intake in response to changing energy requirements is essential for survival. Recent progress has provided an insight into the molecular, cellular and behavioural mechanisms that link changes of body fat stores to adaptive adjustments of feeding behaviour. The physiological importance of this homeostatic control system is highlighted by the severe obesity that results from dysfunction of any of several of its key components. This new information provides a biological context within which to consider the global obesity epidemic and identifies numerous potential avenues for therapeutic intervention and future research.

Suggested Citation

  • G. J. Morton & D. E. Cummings & D. G. Baskin & G. S. Barsh & M. W. Schwartz, 2006. "Central nervous system control of food intake and body weight," Nature, Nature, vol. 443(7109), pages 289-295, September.
    • Handle: RePEc:nat:nature:v:443:y:2006:i:7109:d:10.1038_nature05026
    DOI: 10.1038/nature05026
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    Cited by:

    1. Mingming Xing & Yang Li & Yuqi Zhang & Juemou Zhou & Danting Ma & Mengqi Zhang & Minglei Tang & Ting Ouyang & Fumiao Zhang & Xiaofeng Shi & Jianyuan Sun & Zuxin Chen & Weiping J. Zhang & Shuli Zhang &, 2024. "Paraventricular hypothalamic RUVBL2 neurons suppress appetite by enhancing excitatory synaptic transmission in distinct neurocircuits," Nature Communications, Nature, vol. 15(1), pages 1-21, December.
    2. Sheng Qiu & Qinan Wu & Hao Wang & Dongfang Liu & Chen Chen & Zhiming Zhu & Hongting Zheng & Gangyi Yang & Ling Li & Mengliu Yang, 2024. "AZGP1 in POMC neurons modulates energy homeostasis and metabolism through leptin-mediated STAT3 phosphorylation," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    3. Nathan Fearby & Samantha Penman & Panayotis Thanos, 2022. "Effects of Δ9-Tetrahydrocannibinol (THC) on Obesity at Different Stages of Life: A Literature Review," IJERPH, MDPI, vol. 19(6), pages 1-28, March.
    4. Miharu Tamaoki & Ikumi Honda & Keisuke Nakanishi & Maki Nakajima & Sophathya Cheam & Manabu Okawada & Hisataka Sakakibara, 2022. "Lifestyle Factors Associated with Metabolic Syndrome in Urban Cambodia," IJERPH, MDPI, vol. 19(17), pages 1-11, August.
    5. Laia Guardia-Escote & Jordi Blanco & Pia Basaure & Judit Biosca-Brull & Rikst Nynke Verkaik-Schakel & Maria Cabré & Fiona Peris-Sampedro & Cristian Pérez-Fernández & Fernando Sánchez-Santed & Torsten , 2020. "Sex and Exposure to Postnatal Chlorpyrifos Influence the Epigenetics of Feeding-Related Genes in a Transgenic APOE Mouse Model: Long-Term Implications on Body Weight after a High-Fat Diet," IJERPH, MDPI, vol. 18(1), pages 1-17, December.
    6. Gregorini, Pablo & Beukes, Pierre C. & Romera, Alvaro J. & Levy, Gil & Hanigan, Mark D., 2013. "A model of diurnal grazing patterns and herbage intake of a dairy cow, MINDY: Model description," Ecological Modelling, Elsevier, vol. 270(C), pages 11-29.
    7. Yanine, Franco Fernando & Caballero, Federico I. & Sauma, Enzo E. & Córdova, Felisa M., 2014. "Building sustainable energy systems: Homeostatic control of grid-connected microgrids, as a means to reconcile power supply and energy demand response management," Renewable and Sustainable Energy Reviews, Elsevier, vol. 40(C), pages 1168-1191.
    8. Yunpo Zhao & Mohammed A. Khallaf & Emilia Johansson & Najat Dzaki & Shreelatha Bhat & Johannes Alfredsson & Jianli Duan & Bill S. Hansson & Markus Knaden & Mattias Alenius, 2022. "Hedgehog-mediated gut-taste neuron axis controls sweet perception in Drosophila," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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