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Effects of bilateral anterior agranular insula lesions on food anticipatory activity in rats

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  • Alex M Gavrila
  • Suzanne Hood
  • Barry Robinson
  • Shimon Amir

Abstract

Food anticipatory activity (FAA) refers to a daily rhythm of locomotor activity that emerges under conditions of food restriction, whereby animals develop an intense, predictable period of activity in the few hours leading up to a predictable, daily delivery of food. The neural mechanisms by which FAA is regulated are not yet fully understood. Although a number of brain regions appear to be involved in regulating the development and expression of FAA, there is little evidence to date concerning the role of the anterior agranular insular cortex (AICa). The AICa plays a critical role in integrating the perception of visceral states with motivational behaviour such as feeding. We assessed the effect of bilateral electrolytic or ibotenic acid lesions of the AICa on FAA in male Wistar rats receiving food for varying lengths of time (2 h, 3 h, or 5 h) during the middle of the light phase (starting at either ZT4 or ZT6). Contrary to our initial expectations, we found that both electrolytic and ibotenic acid lesions significantly increased, rather than decreased, the amount of FAA expressed in lesioned rats. Despite increased FAA, lesioned rats did not eat significantly more during restricted feeding (RF) periods than control rats. Similar to controls, AlCa-lesioned rats showed negligible anticipatory activity to a restricted treat suggesting that the increased anticipatory activity in lesioned rats is associated with food restriction, rather than the appetitive value of the meal. Monitoring behaviour in an open field indicated that increased FAA in AlCa-lesioned rats was not explained by a general increase in locomotor activity. Together, these findings suggest that the AICa contributes to the network of brain regions involved in FAA.

Suggested Citation

  • Alex M Gavrila & Suzanne Hood & Barry Robinson & Shimon Amir, 2017. "Effects of bilateral anterior agranular insula lesions on food anticipatory activity in rats," PLOS ONE, Public Library of Science, vol. 12(6), pages 1-21, June.
    • Handle: RePEc:plo:pone00:0179370
    DOI: 10.1371/journal.pone.0179370
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    References listed on IDEAS

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    1. Michael W. Schwartz & Stephen C. Woods & Daniel Porte & Randy J. Seeley & Denis G. Baskin, 2000. "Central nervous system control of food intake," Nature, Nature, vol. 404(6778), pages 661-671, April.
    2. Samuel Greenhouse & Seymour Geisser, 1959. "On methods in the analysis of profile data," Psychometrika, Springer;The Psychometric Society, vol. 24(2), pages 95-112, June.
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