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Maternal dietary fat during lactation shapes single nucleus transcriptomic profile of postnatal offspring hypothalamus in a sexually dimorphic manner in mice

Author

Listed:
  • Yi Huang

    (Chinese Academy of Sciences
    Metabolism Program)

  • Anyongqi Wang

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Wenjiang Zhou

    (Fudan University)

  • Baoguo Li

    (Chinese Academy of Sciences
    Zhengzhou University)

  • Linshan Zhang

    (Fudan University)

  • Agata M. Rudolf

    (Chinese Academy of Sciences)

  • Zengguang Jin

    (Chinese Academy of Sciences)

  • Catherine Hambly

    (University of Aberdeen)

  • Guanlin Wang

    (Fudan University)

  • John R. Speakman

    (Chinese Academy of Sciences
    Chinese Academy of Sciences
    University of Aberdeen
    China Medical University)

Abstract

Maternal overnutrition during lactation predisposes offspring to develop metabolic diseases and exacerbates the relevant syndromes in males more than females in later life. The hypothalamus is a heterogenous brain region that regulates energy balance. Here we combined metabolic trait quantification of mother and offspring mice under low and high fat diet (HFD) feeding during lactation, with single nucleus transcriptomic profiling of their offspring hypothalamus at peak lacation to understand the cellular and molecular alterations in response to maternal dietary pertubation. We found significant expansion in neuronal subpopulations including histaminergic (Hdc), arginine vasopressin/retinoic acid receptor-related orphan receptor β (Avp/Rorb) and agouti-related peptide/neuropeptide Y (AgRP/Npy) in male offspring when their mothers were fed HFD, and increased Npy-astrocyte interactions in offspring responding to maternal overnutrition. Our study provides a comprehensive offspring hypothalamus map at the peak lactation and reveals how the cellular subpopulations respond to maternal dietary fat in a sex-specific manner during development.

Suggested Citation

  • Yi Huang & Anyongqi Wang & Wenjiang Zhou & Baoguo Li & Linshan Zhang & Agata M. Rudolf & Zengguang Jin & Catherine Hambly & Guanlin Wang & John R. Speakman, 2024. "Maternal dietary fat during lactation shapes single nucleus transcriptomic profile of postnatal offspring hypothalamus in a sexually dimorphic manner in mice," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-46589-x
    DOI: 10.1038/s41467-024-46589-x
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