IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v17y2020i18p6811-d415506.html
   My bibliography  Save this article

Effects and Mechanisms of Phthalates’ Action on Reproductive Processes and Reproductive Health: A Literature Review

Author

Listed:
  • Henrieta Hlisníková

    (Department of Zoology and Anthropology, Faculty of Natural Sciences, Constantine the Philosopher University in Nitra, 949 74 Nitra, Slovakia)

  • Ida Petrovičová

    (Department of Zoology and Anthropology, Faculty of Natural Sciences, Constantine the Philosopher University in Nitra, 949 74 Nitra, Slovakia)

  • Branislav Kolena

    (Department of Zoology and Anthropology, Faculty of Natural Sciences, Constantine the Philosopher University in Nitra, 949 74 Nitra, Slovakia)

  • Miroslava Šidlovská

    (Department of Zoology and Anthropology, Faculty of Natural Sciences, Constantine the Philosopher University in Nitra, 949 74 Nitra, Slovakia)

  • Alexander Sirotkin

    (Department of Zoology and Anthropology, Faculty of Natural Sciences, Constantine the Philosopher University in Nitra, 949 74 Nitra, Slovakia)

Abstract

The production of plastic products, which requires phthalate plasticizers, has resulted in the problems for human health, especially that of reproductive health. Phthalate exposure can induce reproductive disorders at various regulatory levels. The aim of this review was to compile the evidence concerning the association between phthalates and reproductive diseases, phthalates-induced reproductive disorders, and their possible endocrine and intracellular mechanisms. Phthalates may induce alterations in puberty, the development of testicular dysgenesis syndrome, cancer, and fertility disorders in both males and females. At the hormonal level, phthalates can modify the release of hypothalamic, pituitary, and peripheral hormones. At the intracellular level, phthalates can interfere with nuclear receptors, membrane receptors, intracellular signaling pathways, and modulate gene expression associated with reproduction. To understand and to treat the adverse effects of phthalates on human health, it is essential to expand the current knowledge concerning their mechanism of action in the organism.

Suggested Citation

  • Henrieta Hlisníková & Ida Petrovičová & Branislav Kolena & Miroslava Šidlovská & Alexander Sirotkin, 2020. "Effects and Mechanisms of Phthalates’ Action on Reproductive Processes and Reproductive Health: A Literature Review," IJERPH, MDPI, vol. 17(18), pages 1-37, September.
  • Handle: RePEc:gam:jijerp:v:17:y:2020:i:18:p:6811-:d:415506
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/17/18/6811/pdf
    Download Restriction: no

    File URL: https://www.mdpi.com/1660-4601/17/18/6811/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Andrzej M. Brzozowski & Ashley C. W. Pike & Zbigniew Dauter & Roderick E. Hubbard & Tomas Bonn & Owe Engström & Lars Öhman & Geoffrey L. Greene & Jan-Åke Gustafsson & Mats Carlquist, 1997. "Molecular basis of agonism and antagonism in the oestrogen receptor," Nature, Nature, vol. 389(6652), pages 753-758, October.
    2. Xiaoheng Li & Xiaomin Chen & Guoxin Hu & Linxi Li & Huina Su & Yiyan Wang & Dongxin Chen & Qiqi Zhu & Chao Li & Junwei Li & Mingcang Wang & Qingquan Lian & Ren-Shan Ge, 2016. "Effects of in Utero Exposure to Dicyclohexyl Phthalate on Rat Fetal Leydig Cells," IJERPH, MDPI, vol. 13(3), pages 1-12, February.
    3. Te Liu & Yiyang Jia & Liting Zhou & Qi Wang & Di Sun & Jin Xu & Juan Wu & Huaiji Chen & Feng Xu & Lin Ye, 2016. "Effects of Di-(2-ethylhexyl) Phthalate on the Hypothalamus–Uterus in Pubertal Female Rats," IJERPH, MDPI, vol. 13(11), pages 1-15, November.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Ilaria Di Napoli & Sara Tagliaferri & Eduardo Sommella & Emanuela Salviati & Debora Porri & Benedetta Raspini & Hellas Cena & Pietro Campiglia & Cinzia La Rocca & Rosa Maria Cerbo & Rachele De Giusepp, 2021. "Lifestyle Habits and Exposure to BPA and Phthalates in Women of Childbearing Age from Northern Italy: A Pilot Study," IJERPH, MDPI, vol. 18(18), pages 1-16, September.
    2. Mariana Segovia-Mendoza & Margarita Isabel Palacios-Arreola & Lenin Pavón & Luis Enrique Becerril & Karen Elizabeth Nava-Castro & Omar Amador-Muñoz & Jorge Morales-Montor, 2022. "Environmental Pollution to Blame for Depressive Disorder?," IJERPH, MDPI, vol. 19(3), pages 1-13, February.
    3. Shuman Sheng & Wei Liu & Yafei Xue & Zhengwu Pan & Lanlan Zhao & Fei Wang & Xiaoyi Qi, 2022. "Follicle-Stimulating Hormone Promotes the Development of Endometrial Cancer In Vitro and In Vivo," IJERPH, MDPI, vol. 19(22), pages 1-11, November.
    4. Lidia Caporossi & Paola Viganò & Enrico Paci & Silvia Capanna & Alessandra Alteri & Daniela Pigini & Giovanna Tranfo & Bruno Papaleo, 2022. "A Case–Control Study on the Effects of Plasticizers Exposure on Male Fertility," IJERPH, MDPI, vol. 20(1), pages 1-14, December.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Wei He & Wenhui Zhang & Zhenhua Chu & Yu Li, 2021. "Mitigating the Adverse Effects of Polychlorinated Biphenyl Derivatives on Estrogenic Activity via Molecular Modification Techniques," IJERPH, MDPI, vol. 18(9), pages 1-19, May.
    2. Terje Svingen, 2016. "Comments on Li et al . Effects of in Utero Exposure to Dicyclohexyl Phthalate on Rat Fetal Leydig Cells. Int. J. Environ. Res. Public Health 2016, 13 , 246," IJERPH, MDPI, vol. 13(6), pages 1-3, May.
    3. Fenglei Li & Qiaoyu Hu & Xianglei Zhang & Renhong Sun & Zhuanghua Liu & Sanan Wu & Siyuan Tian & Xinyue Ma & Zhizhuo Dai & Xiaobao Yang & Shenghua Gao & Fang Bai, 2022. "DeepPROTACs is a deep learning-based targeted degradation predictor for PROTACs," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    4. Haigang Zhang & Chengji Zhao & Hui Na, 2020. "Enhanced Biodegradation of Phthalic Acid Esters’ Derivatives by Plasticizer-Degrading Bacteria ( Burkholderia cepacia , Archaeoglobus fulgidus , Pseudomonas aeruginosa ) Using a Correction 3D-QSAR Mod," IJERPH, MDPI, vol. 17(15), pages 1-17, July.
    5. Siqi Liu & David Jassby & Daniel Mandler & Andrea I. Schäfer, 2024. "Differentiation of adsorption and degradation in steroid hormone micropollutants removal using electrochemical carbon nanotube membrane," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    6. Peixuan Sun & Wenjin Zhao, 2021. "Strategies to Control Human Health Risks Arising from Antibiotics in the Environment: Molecular Modification of QNs for Enhanced Plant–Microbial Synergistic Degradation," IJERPH, MDPI, vol. 18(20), pages 1-26, October.
    7. Michele Samorani & Manuel Laguna & Robert Kirk DeLisle & Daniel C. Weaver, 2011. "A Randomized Exhaustive Propositionalization Approach for Molecule Classification," INFORMS Journal on Computing, INFORMS, vol. 23(3), pages 331-345, August.
    8. Mariana Segovia-Mendoza & Margarita Isabel Palacios-Arreola & Lenin Pavón & Luis Enrique Becerril & Karen Elizabeth Nava-Castro & Omar Amador-Muñoz & Jorge Morales-Montor, 2022. "Environmental Pollution to Blame for Depressive Disorder?," IJERPH, MDPI, vol. 19(3), pages 1-13, February.
    9. Xueyan Chen & Ugur Uzuner & Man Li & Weibing Shi & Joshua S. Yuan & Susie Y. Dai, 2016. "Phytoestrogens and Mycoestrogens Induce Signature Structure Dynamics Changes on Estrogen Receptor α," IJERPH, MDPI, vol. 13(9), pages 1-14, August.
    10. Benjamin M. Steiner & Abigail M. Benvie & Derek Lee & Yuwei Jiang & Daniel C. Berry, 2024. "Cxcr4 regulates a pool of adipocyte progenitors and contributes to adiposity in a sex-dependent manner," Nature Communications, Nature, vol. 15(1), pages 1-21, December.
    11. Wanglong Zheng & Wentong Fan & Nannan Feng & Nanyan Lu & Hui Zou & Jianhong Gu & Yan Yuan & Xuezhong Liu & Jianfa Bai & Jianchun Bian & Zongping Liu, 2019. "The Role of miRNAs in Zearalenone-Promotion of TM3 Cell Proliferation," IJERPH, MDPI, vol. 16(9), pages 1-19, April.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:17:y:2020:i:18:p:6811-:d:415506. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.