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Follicle-Stimulating Hormone Promotes the Development of Endometrial Cancer In Vitro and In Vivo

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  • Shuman Sheng

    (Department of Obstetrics and Gynecology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, 324 Jingwu Road, Jinan 250021, China)

  • Wei Liu

    (Department of Obstetrics and Gynecology, Shandong Provincial Hospital, Shandong University, 324 Jingwu Road, Jinan 250021, China)

  • Yafei Xue

    (Department of Obstetrics and Gynecology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, 324 Jingwu Road, Jinan 250021, China)

  • Zhengwu Pan

    (Department of Obstetrics and Gynecology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, 324 Jingwu Road, Jinan 250021, China)

  • Lanlan Zhao

    (Department of Obstetrics and Gynecology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, 324 Jingwu Road, Jinan 250021, China)

  • Fei Wang

    (Department of Obstetrics and Gynecology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, 324 Jingwu Road, Jinan 250021, China
    Department of Obstetrics and Gynecology, Shandong Provincial Hospital, Shandong University, 324 Jingwu Road, Jinan 250021, China)

  • Xiaoyi Qi

    (Department of Obstetrics and Gynecology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, 324 Jingwu Road, Jinan 250021, China
    Department of Obstetrics and Gynecology, Shandong Provincial Hospital, Shandong University, 324 Jingwu Road, Jinan 250021, China)

Abstract

Endocrine disruptors as risk factors for endometrial cancer (EC) are positively correlated with serum follicle-stimulating hormone (FSH) levels. Additionally, increased FSH is associated with EC. However, its exact mechanism is not yet clear. Therefore, this study investigated how FSH affects the occurrence of EC. Using immunohistochemistry (IHC), immunofluorescence (IF), and Western blot (WB), we found that FSH receptor (FSHR) was expressed in both EC tissues and cell lines. To explore the effect of FSH on EC in vitro , Ishikawa (ISK) cells were cultured in different doses of FSH, and it was found that FSH could promote the proliferation and migration of ISK cells. Furthermore, the detection of key molecules of migration and apoptosis by WB showed that FSH promoted cell migration and inhibited apoptosis. Additionally, FSH decreased AMPK activation. To clarify the effect of FSH on EC in vivo , we subcutaneously planted ISK cells into ovariectomized mice and then gave two of the groups oestradiol (E2). In comparison with the OE (ovariectomy plus E2) and sham groups, the growth rates and weights of the tumors in the OE plus FSH group were significantly higher. The findings above suggest that FSH promotes the proliferation and metastasis of EC, providing a new strategy for the treatment of EC.

Suggested Citation

  • Shuman Sheng & Wei Liu & Yafei Xue & Zhengwu Pan & Lanlan Zhao & Fei Wang & Xiaoyi Qi, 2022. "Follicle-Stimulating Hormone Promotes the Development of Endometrial Cancer In Vitro and In Vivo," IJERPH, MDPI, vol. 19(22), pages 1-11, November.
    • Handle: RePEc:gam:jijerp:v:19:y:2022:i:22:p:15344-:d:978653
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    References listed on IDEAS

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    1. Jelonia T. Rumph & Victoria R. Stephens & Joanie L. Martin & LaKendria K. Brown & Portia L. Thomas & Ayorinde Cooley & Kevin G. Osteen & Kaylon L. Bruner-Tran, 2022. "Uncovering Evidence: Associations between Environmental Contaminants and Disparities in Women’s Health," IJERPH, MDPI, vol. 19(3), pages 1-22, January.
    2. Rita Canipari & Lucia De Santis & Sandra Cecconi, 2020. "Female Fertility and Environmental Pollution," IJERPH, MDPI, vol. 17(23), pages 1-18, November.
    3. Maddalena Mallozzi & Chiara Leone & Francesca Manurita & Filippo Bellati & Donatella Caserta, 2017. "Endocrine Disrupting Chemicals and Endometrial Cancer: An Overview of Recent Laboratory Evidence and Epidemiological Studies," IJERPH, MDPI, vol. 14(3), pages 1-23, March.
    4. Henrieta Hlisníková & Ida Petrovičová & Branislav Kolena & Miroslava Šidlovská & Alexander Sirotkin, 2020. "Effects and Mechanisms of Phthalates’ Action on Reproductive Processes and Reproductive Health: A Literature Review," IJERPH, MDPI, vol. 17(18), pages 1-37, September.
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