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The Influence of Quercetin on Maternal Immunity, Oxidative Stress, and Inflammation in Mice with Exposure of Fine Particulate Matter during Gestation

Author

Listed:
  • Wei Liu

    (Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China)

  • Minjia Zhang

    (Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China)

  • Jinqiu Feng

    (Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China)

  • Aiqin Fan

    (Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China)

  • Yalin Zhou

    (Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China)

  • Yajun Xu

    (Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China
    Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, Peking University, Beijing 100191, China)

Abstract

The objective is to investigate the influence of PM 2.5 exposure on peripheral blood lymphocyte subsets in pregnant mice and the antagonism of quercetin on adverse effects induced by PM 2.5 exposure. Pregnant mice were randomly divided into control group, PM 2.5 model group and 3 quercetin intervention groups. Dams in all groups except the control group were exposed to PM 2.5 suspension by intratracheal instillation on gestational day (GD) 3, 6, 9, 12 and 15. Meanwhile, each dam was given 0.15% carboxymethylcellulose sodium (CMCS) (control group & PM 2.5 model group) and different doses of quercetin (quercetin intervention groups) by gavage once a day from GD0 to GD17. The percentage of lymphocyte subsets, Biomarkers of systemic inflammation injuries (IL-2, IL-6, IL-8 & TNF-α) and oxidative stress indicators (CAT, GSH & HO-1) in peripheral blood of the dams were analyzed. The number of T cells increased, accompanied by increased level of IL-2, IL-6, IL-8 and HO-1 due to PM 2.5 exposure. Less CD4+ and CD8+ T cells were counted in 100 mg/kg quercetin intervention group, compared with PM 2.5 model group. Quercetin may inhibit cytokine production, especially in IL-6 and IL-8 and may upgrade the level of HO-1. Our findings indicate that PM 2.5 could significantly influence the distribution of T-lymphocyte subsets, activate inflammatory reaction and elevate oxidative stress level in peripheral blood of pregnant mice. Certain dose of quercetin administration during pregnancy may protect the dams against the adverse effects through various ways.

Suggested Citation

  • Wei Liu & Minjia Zhang & Jinqiu Feng & Aiqin Fan & Yalin Zhou & Yajun Xu, 2017. "The Influence of Quercetin on Maternal Immunity, Oxidative Stress, and Inflammation in Mice with Exposure of Fine Particulate Matter during Gestation," IJERPH, MDPI, vol. 14(6), pages 1-16, June.
    • Handle: RePEc:gam:jijerp:v:14:y:2017:i:6:p:592-:d:100302
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    References listed on IDEAS

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    1. Yiling Pei & Rongfang Jiang & Yunzeng Zou & Yu Wang & Suhui Zhang & Guanghe Wang & Jinzhuo Zhao & Weimin Song, 2016. "Effects of Fine Particulate Matter (PM 2.5 ) on Systemic Oxidative Stress and Cardiac Function in ApoE −/− Mice," IJERPH, MDPI, vol. 13(5), pages 1-15, May.
    2. Bin Luo & Hongxia Shi & Lina Wang & Yanrong Shi & Cheng Wang & Jingli Yang & Yaxiong Wan & Jingping Niu, 2014. "Rat Lung Response to PM 2.5 Exposure under Different Cold Stresses," IJERPH, MDPI, vol. 11(12), pages 1-12, December.
    3. Grace Y Sun & Zihong Chen & Kimberly J Jasmer & Dennis Y Chuang & Zezong Gu & Mark Hannink & Agnes Simonyi, 2015. "Quercetin Attenuates Inflammatory Responses in BV-2 Microglial Cells: Role of MAPKs on the Nrf2 Pathway and Induction of Heme Oxygenase-1," PLOS ONE, Public Library of Science, vol. 10(10), pages 1-20, October.
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    Cited by:

    1. Wei Liu & Yalin Zhou & Yong Qin & Yong Li & Lanlan Yu & Ruijun Li & Yuhan Chen & Yajun Xu, 2019. "Sex-Dependent Effects of PM 2.5 Maternal Exposure and Quercetin Intervention on Offspring’s Short Chain Fatty Acids," IJERPH, MDPI, vol. 16(22), pages 1-11, November.

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