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Endocrine Disrupting Chemicals and Endometrial Cancer: An Overview of Recent Laboratory Evidence and Epidemiological Studies

Author

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  • Maddalena Mallozzi

    (Surgical and Medical Department of Translational Medicine, Sant’Andrea Hospital, Faculty of Medicine and Psycology, University of Rome “Sapienza”, Via di Grottarossa n° 1035, 00139 Rome, Italy)

  • Chiara Leone

    (Surgical and Medical Department of Translational Medicine, Sant’Andrea Hospital, Faculty of Medicine and Psycology, University of Rome “Sapienza”, Via di Grottarossa n° 1035, 00139 Rome, Italy)

  • Francesca Manurita

    (Surgical and Medical Department of Translational Medicine, Sant’Andrea Hospital, Faculty of Medicine and Psycology, University of Rome “Sapienza”, Via di Grottarossa n° 1035, 00139 Rome, Italy)

  • Filippo Bellati

    (Surgical and Medical Department of Translational Medicine, Sant’Andrea Hospital, Faculty of Medicine and Psycology, University of Rome “Sapienza”, Via di Grottarossa n° 1035, 00139 Rome, Italy)

  • Donatella Caserta

    (Surgical and Medical Department of Translational Medicine, Sant’Andrea Hospital, Faculty of Medicine and Psycology, University of Rome “Sapienza”, Via di Grottarossa n° 1035, 00139 Rome, Italy)

Abstract

Background : Although exposure to endocrine disruptor compounds (EDCs) has been suggested as a contributing factor to a range of women’s health disorders including infertility, polycystic ovaries and the early onset of puberty, considerable challenges remain in attributing cause and effect on gynaecological cancer. Until recently, there were relatively few epidemiological studies examining the relationship between EDCs and endometrial cancer, however, in the last years the number of these studies has increased. Methods : A systematic MEDLINE (PubMed) search was performed and relevant articles published in the last 23 years (from 1992 to 2016) were selected. Results : Human studies and animal experiments are confirming a carcinogenic effect due to the EDC exposure and its carcinogenesis process result to be complex, multifactorial and long standing, thus, it is extremely difficult to obtain the epidemiological proof of a carcinogenic effect of EDCs for the high number of confusing factors. Conclusions : The carcinogenic effects of endocrine disruptors are plausible, although additional studies are needed to clarify their mechanisms and responsible entities. Neverthless, to reduce endocrine disruptors (ED) exposure is mandatory to implement necessary measures to limit exposure, particularly during those periods of life most vulnerable to the impact of oncogenic environmental causes, such as embryonic period and puberty.

Suggested Citation

  • Maddalena Mallozzi & Chiara Leone & Francesca Manurita & Filippo Bellati & Donatella Caserta, 2017. "Endocrine Disrupting Chemicals and Endometrial Cancer: An Overview of Recent Laboratory Evidence and Epidemiological Studies," IJERPH, MDPI, vol. 14(3), pages 1-23, March.
    • Handle: RePEc:gam:jijerp:v:14:y:2017:i:3:p:334-:d:93799
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    References listed on IDEAS

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    1. Cinzia La Rocca & Sabrina Tait & Cristiana Guerranti & Luca Busani & Francesca Ciardo & Bruno Bergamasco & Guido Perra & Francesca Romana Mancini & Roberto Marci & Giulia Bordi & Donatella Caserta & S, 2015. "Exposure to Endocrine Disruptors and Nuclear Receptors Gene Expression in Infertile and Fertile Men from Italian Areas with Different Environmental Features," IJERPH, MDPI, vol. 12(10), pages 1-20, October.
    2. Little, R.E. & Monaghan, S.C. & Gladen, B.C. & Shkyryak-Nyzhnyk, Z.A. & Wilcox, A.J., 1999. "Outcomes of 17137 pregnancies in 2 urban areas of Ukraine," American Journal of Public Health, American Public Health Association, vol. 89(12), pages 1832-1836.
    3. Guergana Mileva & Stephanie L. Baker & Anne T.M. Konkle & Catherine Bielajew, 2014. "Bisphenol-A: Epigenetic Reprogramming and Effects on Reproduction and Behavior," IJERPH, MDPI, vol. 11(7), pages 1-25, July.
    4. Patricia A. Richter & Ellen E. Bishop & Jiantong Wang & Monica H. Swahn, 2009. "Tobacco Smoke Exposure and Levels of Urinary Metals in the U.S. Youth and Adult Population: The National Health and Nutrition Examination Survey (NHANES) 1999–2004," IJERPH, MDPI, vol. 6(7), pages 1-17, July.
    5. Young Ae Cho & Jeongseon Kim & Hae Dong Woo & Moonsu Kang, 2013. "Dietary Cadmium Intake and the Risk of Cancer: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(9), pages 1-1, September.
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    2. Shuman Sheng & Wei Liu & Yafei Xue & Zhengwu Pan & Lanlan Zhao & Fei Wang & Xiaoyi Qi, 2022. "Follicle-Stimulating Hormone Promotes the Development of Endometrial Cancer In Vitro and In Vivo," IJERPH, MDPI, vol. 19(22), pages 1-11, November.
    3. Fu-Kuei Chang & Jentaie Shiea & Hsin-Jen Tsai, 2017. "Urinary Concentrations of Triclosan, Benzophenone-3, and Bisphenol A in Taiwanese Children and Adolescents," IJERPH, MDPI, vol. 14(12), pages 1-10, December.
    4. Alberto Leonardi & Marta Cofini & Donato Rigante & Laura Lucchetti & Clelia Cipolla & Laura Penta & Susanna Esposito, 2017. "The Effect of Bisphenol A on Puberty: A Critical Review of the Medical Literature," IJERPH, MDPI, vol. 14(9), pages 1-20, September.

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