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Bisphenol-A: Epigenetic Reprogramming and Effects on Reproduction and Behavior

Author

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  • Guergana Mileva

    (School of Psychology, University of Ottawa, 136 Jean Jacques Lussier, Vanier Hall, Ottawa, ON K1N 6N5, Canada)

  • Stephanie L. Baker

    (School of Psychology, University of Ottawa, 136 Jean Jacques Lussier, Vanier Hall, Ottawa, ON K1N 6N5, Canada)

  • Anne T.M. Konkle

    (School of Psychology, University of Ottawa, 136 Jean Jacques Lussier, Vanier Hall, Ottawa, ON K1N 6N5, Canada
    Interdisciplinary School of Health Sciences, University of Ottawa, 25 University Private, Thompson Hall, Ottawa, ON K1N 6X1, Canada)

  • Catherine Bielajew

    (School of Psychology, University of Ottawa, 136 Jean Jacques Lussier, Vanier Hall, Ottawa, ON K1N 6N5, Canada)

Abstract

Bisphenol A (BPA) is a synthetic compound used in the production of many polycarbonate plastics and epoxy resins. It is one of the most widely produced chemicals in the world today and is found in most canned goods, plastics, and even household dust. Exposure to BPA is almost universal: most people have measurable amounts of BPA in both urine and serum. BPA is similar in structure to estradiol and can bind to multiple targets both inside and outside the nucleus, in effect acting as an endocrine disruptor. Research on BPA exposure has accelerated in the past decade with findings suggesting that perinatal exposure to BPA can negatively impact both male and female reproduction, create alterations in behavior, and act as a carcinogen. BPA can have both short term and long term effects with the latter typically occurring through epigenetic mechanisms such as DNA methylation. This review will draw on both human and animal studies in an attempt to synthesize the literature and examine the effects of BPA exposure on reproduction, behavior, and carcinogenesis with a focus on the potential epigenetic mechanisms by which it acts.

Suggested Citation

  • Guergana Mileva & Stephanie L. Baker & Anne T.M. Konkle & Catherine Bielajew, 2014. "Bisphenol-A: Epigenetic Reprogramming and Effects on Reproduction and Behavior," IJERPH, MDPI, vol. 11(7), pages 1-25, July.
    • Handle: RePEc:gam:jijerp:v:11:y:2014:i:7:p:7537-7561:d:38412
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    Citations

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    Cited by:

    1. Francesca Farrugia & Alexia Aquilina & Josanne Vassallo & Nikolai Paul Pace, 2021. "Bisphenol A and Type 2 Diabetes Mellitus: A Review of Epidemiologic, Functional, and Early Life Factors," IJERPH, MDPI, vol. 18(2), pages 1-26, January.
    2. T. Žalmanová & K. Hošková & J. Nevoral & Š. Prokešová & K. Zámostná & T. Kott & J. Petr, 2016. "Bisphenol S instead of bisphenol A: a story of reproductive disruption by regretable substitution - a review," Czech Journal of Animal Science, Czech Academy of Agricultural Sciences, vol. 61(10), pages 433-449.
    3. Maddalena Mallozzi & Chiara Leone & Francesca Manurita & Filippo Bellati & Donatella Caserta, 2017. "Endocrine Disrupting Chemicals and Endometrial Cancer: An Overview of Recent Laboratory Evidence and Epidemiological Studies," IJERPH, MDPI, vol. 14(3), pages 1-23, March.
    4. Xiuxia Song & Maohua Miao & Xiaoyu Zhou & Dekun Li & Youping Tian & Hong Liang & Runsheng Li & Wei Yuan, 2019. "Bisphenol A Exposure and Sperm ACHE Hydroxymethylation in Men," IJERPH, MDPI, vol. 16(1), pages 1-12, January.

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