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The Effect of Bisphenol A on Puberty: A Critical Review of the Medical Literature

Author

Listed:
  • Alberto Leonardi

    (Pediatric Clinic, Department of Surgical and Biomedical Sciences, Università degli Studi di Perugia, 06129 Perugia, Italy)

  • Marta Cofini

    (Pediatric Clinic, Department of Surgical and Biomedical Sciences, Università degli Studi di Perugia, 06129 Perugia, Italy)

  • Donato Rigante

    (Institute of Pediatrics, Università Cattolica Sacro Cuore, Fondazione Policlinico Universitario A. Gemelli, 00168 Rome, Italy)

  • Laura Lucchetti

    (Pediatric Clinic, Department of Surgical and Biomedical Sciences, Università degli Studi di Perugia, 06129 Perugia, Italy)

  • Clelia Cipolla

    (Institute of Pediatrics, Università Cattolica Sacro Cuore, Fondazione Policlinico Universitario A. Gemelli, 00168 Rome, Italy)

  • Laura Penta

    (Pediatric Clinic, Department of Surgical and Biomedical Sciences, Università degli Studi di Perugia, 06129 Perugia, Italy)

  • Susanna Esposito

    (Pediatric Clinic, Department of Surgical and Biomedical Sciences, Università degli Studi di Perugia, 06129 Perugia, Italy)

Abstract

Many scientific studies have revealed a trend towards an earlier onset of puberty and have disclosed an increasing number of children that display precocious puberty. As an explanation, some authors have considered the global socio-economic improvement across different populations, and other authors have considered the action of endocrine disrupting chemicals (EDCs). Among these, bisphenol A (BPA), an aromatic compound largely used worldwide as a precursor of some plastics and chemical additives, is well known for its molecular oestrogen-like and obesogenic actions. We reviewed the medical literature of the previous 20 years that examined associations between BPA exposure and the age of puberty in humans, considering only those referring to clinical or epidemiological data. Of 19 studies, only 7 showed a correlation between BPA and puberty. In particular, the possible disruptive role of BPA on puberty may be seen in those with central precocious puberty or isolated premature breast development aged 2 months to 4 years old, even if the mechanism is undefined. Some studies also found a close relationship between urinary BPA, body weight, and early puberty, which can be explained by the obesogenic effect of BPA itself. The currently available data do not allow establishment of a clear role for BPA in pubertal development because of the conflicting results among all clinical and epidemiological studies examined. Further research is needed to fully understand the potential role of exposure to EDCs and their adverse endocrine health outcomes.

Suggested Citation

  • Alberto Leonardi & Marta Cofini & Donato Rigante & Laura Lucchetti & Clelia Cipolla & Laura Penta & Susanna Esposito, 2017. "The Effect of Bisphenol A on Puberty: A Critical Review of the Medical Literature," IJERPH, MDPI, vol. 14(9), pages 1-20, September.
    • Handle: RePEc:gam:jijerp:v:14:y:2017:i:9:p:1044-:d:111486
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    References listed on IDEAS

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    1. Maddalena Mallozzi & Chiara Leone & Francesca Manurita & Filippo Bellati & Donatella Caserta, 2017. "Endocrine Disrupting Chemicals and Endometrial Cancer: An Overview of Recent Laboratory Evidence and Epidemiological Studies," IJERPH, MDPI, vol. 14(3), pages 1-23, March.
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    Cited by:

    1. Renata E. Howland & Nicole C. Deziel & Gillian R. Bentley & Mark Booth & Osul A. Choudhury & Jonathan N. Hofmann & Robert N. Hoover & Hormuzd A. Katki & Britton Trabert & Stephen D. Fox & Rebecca Troi, 2020. "Assessing Endogenous and Exogenous Hormone Exposures and Breast Development in a Migrant Study of Bangladeshi and British Girls," IJERPH, MDPI, vol. 17(4), pages 1-12, February.

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