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Exposure to Endocrine Disruptors and Nuclear Receptors Gene Expression in Infertile and Fertile Men from Italian Areas with Different Environmental Features

Author

Listed:
  • Cinzia La Rocca

    (Department of Food Safety and Veterinary Public Health, Istituto Superiore di Sanità, Roma 00161, Italy)

  • Sabrina Tait

    (Department of Food Safety and Veterinary Public Health, Istituto Superiore di Sanità, Roma 00161, Italy)

  • Cristiana Guerranti

    (Department of Physical, Earth and Environmental Sciences, University of Siena, Siena 53100, Italy
    Bioscience Research Center, Orbetello (GR) 58015, Italy)

  • Luca Busani

    (Department of Food Safety and Veterinary Public Health, Istituto Superiore di Sanità, Roma 00161, Italy)

  • Francesca Ciardo

    (Department of Obstetric and Gynecological Sciences and Urological Sciences, University of Roma Sapienza, S. Andrea Hospital, Roma 00189, Italy)

  • Bruno Bergamasco

    (Department of Food Safety and Veterinary Public Health, Istituto Superiore di Sanità, Roma 00161, Italy)

  • Guido Perra

    (Department of Physical, Earth and Environmental Sciences, University of Siena, Siena 53100, Italy)

  • Francesca Romana Mancini

    (Department of Food Safety and Veterinary Public Health, Istituto Superiore di Sanità, Roma 00161, Italy)

  • Roberto Marci

    (Department of Biomedical Sciences and Advanced Therapies, Section of Obstetrics and Gynaecology, University of Ferrara, Ferrara 44124, Italy)

  • Giulia Bordi

    (Department of Obstetric and Gynecological Sciences and Urological Sciences, University of Roma Sapienza, S. Andrea Hospital, Roma 00189, Italy)

  • Donatella Caserta

    (Department of Obstetric and Gynecological Sciences and Urological Sciences, University of Roma Sapienza, S. Andrea Hospital, Roma 00189, Italy)

  • Silvano Focardi

    (Department of Physical, Earth and Environmental Sciences, University of Siena, Siena 53100, Italy)

  • Massimo Moscarini

    (Department of Obstetric and Gynecological Sciences and Urological Sciences, University of Roma Sapienza, S. Andrea Hospital, Roma 00189, Italy)

  • Alberto Mantovani

    (Department of Food Safety and Veterinary Public Health, Istituto Superiore di Sanità, Roma 00161, Italy)

Abstract

Internal levels of selected endocrine disruptors (EDs) ( i.e ., perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), di-2-ethylhexyl-phthalate (DEHP), mono-(2-ethylhexyl)-phthalate (MEHP), and bisphenol A (BPA)) were analyzed in blood/serum of infertile and fertile men from metropolitan, urban and rural Italian areas. PFOS and PFOA levels were also evaluated in seminal plasma. In peripheral blood mononuclear cells (PBMCs) of same subjects, gene expression levels of a panel of nuclear receptors (NRs), namely estrogen receptor α (ERα) estrogen receptor β (ERβ), androgen receptor (AR), aryl hydrocarbon receptor (AhR), peroxisome proliferator-activated receptor γ (PPARγ) and pregnane X receptor (PXR) were also assessed. Infertile men from the metropolitan area had significantly higher levels of BPA and gene expression of all NRs, except PPARγ, compared to subjects from other areas. Subjects from urban areas had significantly higher levels of MEHP, whereas subjects from rural area had higher levels of PFOA in both blood and seminal plasma. Interestingly, ERα, ERβ, AR, PXR and AhR expression is directly correlated with BPA and inversely correlated with PFOA serum levels. Our study indicates the relevance of the living environment when investigating the exposure to specific EDs. Moreover, the NRs panel in PBMCs demonstrated to be a potential biomarker of effect to assess the EDs impact on reproductive health.

Suggested Citation

  • Cinzia La Rocca & Sabrina Tait & Cristiana Guerranti & Luca Busani & Francesca Ciardo & Bruno Bergamasco & Guido Perra & Francesca Romana Mancini & Roberto Marci & Giulia Bordi & Donatella Caserta & S, 2015. "Exposure to Endocrine Disruptors and Nuclear Receptors Gene Expression in Infertile and Fertile Men from Italian Areas with Different Environmental Features," IJERPH, MDPI, vol. 12(10), pages 1-20, October.
    • Handle: RePEc:gam:jijerp:v:12:y:2015:i:10:p:12426-12445:d:56761
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    References listed on IDEAS

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    1. Cinzia La Rocca & Sabrina Tait & Cristiana Guerranti & Luca Busani & Francesca Ciardo & Bruno Bergamasco & Laura Stecca & Guido Perra & Francesca Romana Mancini & Roberto Marci & Giulia Bordi & Donate, 2014. "Exposure to Endocrine Disrupters and Nuclear Receptor Gene Expression in Infertile and Fertile Women from Different Italian Areas," IJERPH, MDPI, vol. 11(10), pages 1-19, September.
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    Cited by:

    1. Yuan Meng & Ren Lin & Fengjuan Wu & Qi Sun & Lihong Jia, 2018. "Decreased Capacity for Sperm Production Induced by Perinatal Bisphenol A Exposure Is Associated with an Increased Inflammatory Response in the Offspring of C57BL/6 Male Mice," IJERPH, MDPI, vol. 15(10), pages 1-11, October.
    2. Francesca Nappi & Luigi Barrea & Carolina Di Somma & Maria Cristina Savanelli & Giovanna Muscogiuri & Francesco Orio & Silvia Savastano, 2016. "Endocrine Aspects of Environmental “Obesogen” Pollutants," IJERPH, MDPI, vol. 13(8), pages 1-16, July.
    3. Maddalena Mallozzi & Chiara Leone & Francesca Manurita & Filippo Bellati & Donatella Caserta, 2017. "Endocrine Disrupting Chemicals and Endometrial Cancer: An Overview of Recent Laboratory Evidence and Epidemiological Studies," IJERPH, MDPI, vol. 14(3), pages 1-23, March.

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    1. Yuan Meng & Ren Lin & Fengjuan Wu & Qi Sun & Lihong Jia, 2018. "Decreased Capacity for Sperm Production Induced by Perinatal Bisphenol A Exposure Is Associated with an Increased Inflammatory Response in the Offspring of C57BL/6 Male Mice," IJERPH, MDPI, vol. 15(10), pages 1-11, October.

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