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Scaling up xylitol bioproduction: Challenges to achieve a profitable bioprocess

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  • Queiroz, Sarah S.
  • Jofre, Fanny M.
  • Mussatto, Solange I.
  • Felipe, Maria das Graças A.

Abstract

Xylitol is a GRAS (Generally Recognized as Safe) polyol commonly used in the food industry and able to promote several benefits to the health. In addition, it can also be used as a building block molecule for the manufacture of different high-value chemicals. Currently, the commercial production of xylitol occurs by chemical route through the catalytic hydrogenation of xylose from lignocellulosic biomass. Since this is an expensive process due to the severe reactional conditions employed, the biotechnological route for xylitol production, which comprises the biological conversion of xylose into xylitol, emerges as a potential lower-cost alternative to obtain this polyol due to the milder process conditions required. However, the biotechnological route still presents important bottlenecks and challenges that impairs the process scaling up. Modern strategies and technologies that can potentially improve xylitol bioproduction include adaptive evolution of microbial strains to enhance their tolerance to inhibitors and the xylose uptake rate during the fermentation step; development of engineered microorganisms to result in higher xylose-to-xylitol bioconversion yields; as well as xylitol purification techniques to improve the recovery yields. Moreover, techno-economic analysis of the overall production chain is essential to identify the process viability for large-scale implementation as well as the steps requiring improvements. These are some key factors discussed in this review, which aims to provide insights for the development of a more economically competitive, less energy demanding and scalable new technology for xylitol production.

Suggested Citation

  • Queiroz, Sarah S. & Jofre, Fanny M. & Mussatto, Solange I. & Felipe, Maria das Graças A., 2022. "Scaling up xylitol bioproduction: Challenges to achieve a profitable bioprocess," Renewable and Sustainable Energy Reviews, Elsevier, vol. 154(C).
    • Handle: RePEc:eee:rensus:v:154:y:2022:i:c:s1364032121010583
    DOI: 10.1016/j.rser.2021.111789
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    References listed on IDEAS

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    1. Hernández, Valentina & Romero-García, Juan M. & Dávila, Javier A. & Castro, Eulogio & Cardona, Carlos A., 2014. "Techno-economic and environmental assessment of an olive stone based biorefinery," Resources, Conservation & Recycling, Elsevier, vol. 92(C), pages 145-150.
    2. Xu, Chunping & Paone, Emilia & Rodríguez-Padrón, Daily & Luque, Rafael & Mauriello, Francesco, 2020. "Reductive catalytic routes towards sustainable production of hydrogen, fuels and chemicals from biomass derived polyols," Renewable and Sustainable Energy Reviews, Elsevier, vol. 127(C).
    3. Landaeta, Roberto & Aroca, Germán & Acevedo, Fernando & Teixeira, José A. & Mussatto, Solange I., 2013. "Adaptation of a flocculent Saccharomyces cerevisiae strain to lignocellulosic inhibitors by cell recycle batch fermentation," Applied Energy, Elsevier, vol. 102(C), pages 124-130.
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    Cited by:

    1. Vinícius P. Shibukawa & Lucas Ramos & Mónica M. Cruz-Santos & Carina A. Prado & Fanny M. Jofre & Gabriel L. de Arruda & Silvio S. da Silva & Solange I. Mussatto & Júlio C. dos Santos, 2023. "Impact of Product Diversification on the Economic Sustainability of Second-Generation Ethanol Biorefineries: A Critical Review," Energies, MDPI, vol. 16(17), pages 1-30, September.
    2. Su Lwin Htike & Julaluk Khemacheewakul & Charin Techapun & Yuthana Phimolsiripol & Pornchai Rachtanapun & Suphat Phongthai & Worasit Tochampa & Siraphat Taesuwan & Kittisak Jantanasakulwong & Kritsada, 2024. "Production of Xylitol and Ethanol from Agricultural Wastes and Biotransformation of Phenylacetylcarbinol in Deep Eutectic Solvent," Agriculture, MDPI, vol. 14(11), pages 1-23, November.

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