IDEAS home Printed from https://ideas.repec.org/a/eee/chsofr/v148y2021ics0960077921003908.html
   My bibliography  Save this article

Role of immunotherapy in tumor-immune interaction: Perspectives from fractional-order modelling and sensitivity analysis

Author

Listed:
  • Ndenda, J.P.
  • Njagarah, J.B.H.
  • Shaw, S.

Abstract

Immunotherapy plays a vital role in strengthening the immune system and enhancing its ability to fight cancer during the tumor-immune interaction. This interaction is a complex process and biological studies are still ongoing to explore the tumor microenvironment with the action of the immune system. The limitations associated with ethical consideration and the costs associated with the biological experiments on human samples, motivate researchers to use other available means, including mathematical modelling to find possible solutions to the problems. In this study, we use a fractional model for tumor-immune interaction incorporating the treatment of cytokine interleukin-2 (IL-2) to boost the immune system to fight cancer. The basic properties of the model such as positivity of the solutions and local stability analysis of the tumor free equilibrium are studied and the conditions for tumor removal highlighted. Furthermore, the existence and uniqueness of solution of the model is proved using the fixed point theory. Given the uncertainty in the selection of model parameters, sensitivity analysis was performed using the Latin Hypercube Sampling scheme to determine model parameters which describe the processes that significantly influence the changes in the model state variables. The model was numerically solved for different orders of the fractional derivative using the Adams–Bashforth–Moulton Method. Our results suggest that, satisfactory stable tumor control can be achieved by adoptive cellular immunotherapy (ACI) alone, or through a combination of ACI and IL-2. We further observed that, the processes affecting the tumor-immune system interaction influence the dynamics variably at different stages of the disease. This observation is vital in informing researchers about the essential processes of emphasis when implementing drug targeting intervention measures aimed at curtailing the progression of cancer.

Suggested Citation

  • Ndenda, J.P. & Njagarah, J.B.H. & Shaw, S., 2021. "Role of immunotherapy in tumor-immune interaction: Perspectives from fractional-order modelling and sensitivity analysis," Chaos, Solitons & Fractals, Elsevier, vol. 148(C).
  • Handle: RePEc:eee:chsofr:v:148:y:2021:i:c:s0960077921003908
    DOI: 10.1016/j.chaos.2021.111036
    as

    Download full text from publisher

    File URL: http://www.sciencedirect.com/science/article/pii/S0960077921003908
    Download Restriction: Full text for ScienceDirect subscribers only

    File URL: https://libkey.io/10.1016/j.chaos.2021.111036?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Njagarah, J.B.H. & Tabi, C.B., 2018. "Spatial synchrony in fractional order metapopulation cholera transmission," Chaos, Solitons & Fractals, Elsevier, vol. 117(C), pages 37-49.
    2. Shah, Kamal & Alqudah, Manar A. & Jarad, Fahd & Abdeljawad, Thabet, 2020. "Semi-analytical study of Pine Wilt Disease model with convex rate under Caputo–Febrizio fractional order derivative," Chaos, Solitons & Fractals, Elsevier, vol. 135(C).
    3. Qureshi, Sania & Yusuf, Abdullahi, 2019. "Modeling chickenpox disease with fractional derivatives: From caputo to atangana-baleanu," Chaos, Solitons & Fractals, Elsevier, vol. 122(C), pages 111-118.
    4. Xiaoyi Tang & Ting Liu & Xuefeng Zang & Hao Liu & Danhong Wang & Hu Chen & Bin Zhang, 2013. "Adoptive Cellular Immunotherapy in Metastatic Renal Cell Carcinoma: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(5), pages 1-6, May.
    5. Kassa, Semu M. & Njagarah, John B.H. & Terefe, Yibeltal A., 2020. "Analysis of the mitigation strategies for COVID-19: From mathematical modelling perspective," Chaos, Solitons & Fractals, Elsevier, vol. 138(C).
    6. Balcı, Ercan & Öztürk, İlhan & Kartal, Senol, 2019. "Dynamical behaviour of fractional order tumor model with Caputo and conformable fractional derivative," Chaos, Solitons & Fractals, Elsevier, vol. 123(C), pages 43-51.
    7. Rihan, F.A. & Velmurugan, G., 2020. "Dynamics of fractional-order delay differential model for tumor-immune system," Chaos, Solitons & Fractals, Elsevier, vol. 132(C).
    8. Fathalla A. Rihan, 2013. "Numerical Modeling of Fractional-Order Biological Systems," Abstract and Applied Analysis, Hindawi, vol. 2013, pages 1-11, August.
    9. Ahmad, Shabir & Ullah, Aman & Arfan, Muhammad & Shah, Kamal, 2020. "On analysis of the fractional mathematical model of rotavirus epidemic with the effects of breastfeeding and vaccination under Atangana-Baleanu (AB) derivative," Chaos, Solitons & Fractals, Elsevier, vol. 140(C).
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Kumar, Sunil & Kumar, Ajay & Samet, Bessem & Gómez-Aguilar, J.F. & Osman, M.S., 2020. "A chaos study of tumor and effector cells in fractional tumor-immune model for cancer treatment," Chaos, Solitons & Fractals, Elsevier, vol. 141(C).
    2. DAŞBAŞI, Bahatdin, 2020. "Stability analysis of the hiv model through incommensurate fractional-order nonlinear system," Chaos, Solitons & Fractals, Elsevier, vol. 137(C).
    3. Rihan, F.A. & Rajivganthi, C, 2020. "Dynamics of fractional-order delay differential model of prey-predator system with Holling-type III and infection among predators," Chaos, Solitons & Fractals, Elsevier, vol. 141(C).
    4. Nazir, Ghazala & Shah, Kamal & Debbouche, Amar & Khan, Rahmat Ali, 2020. "Study of HIV mathematical model under nonsingular kernel type derivative of fractional order," Chaos, Solitons & Fractals, Elsevier, vol. 139(C).
    5. Asamoah, Joshua Kiddy K. & Okyere, Eric & Yankson, Ernest & Opoku, Alex Akwasi & Adom-Konadu, Agnes & Acheampong, Edward & Arthur, Yarhands Dissou, 2022. "Non-fractional and fractional mathematical analysis and simulations for Q fever," Chaos, Solitons & Fractals, Elsevier, vol. 156(C).
    6. Ullah, Ihsan & Ahmad, Saeed & Rahman, Mati ur & Arfan, Muhammad, 2021. "Investigation of fractional order tuberculosis (TB) model via Caputo derivative," Chaos, Solitons & Fractals, Elsevier, vol. 142(C).
    7. Abro, Kashif Ali & Khan, Ilyas & Nisar, Kottakkaran Sooppy, 2019. "Novel technique of Atangana and Baleanu for heat dissipation in transmission line of electrical circuit," Chaos, Solitons & Fractals, Elsevier, vol. 129(C), pages 40-45.
    8. Asamoah, Joshua Kiddy K. & Owusu, Mark A. & Jin, Zhen & Oduro, F. T. & Abidemi, Afeez & Gyasi, Esther Opoku, 2020. "Global stability and cost-effectiveness analysis of COVID-19 considering the impact of the environment: using data from Ghana," Chaos, Solitons & Fractals, Elsevier, vol. 140(C).
    9. Rahman, Mati ur & Arfan, Muhammad & Shah, Kamal & Gómez-Aguilar, J.F., 2020. "Investigating a nonlinear dynamical model of COVID-19 disease under fuzzy caputo, random and ABC fractional order derivative," Chaos, Solitons & Fractals, Elsevier, vol. 140(C).
    10. Qureshi, Sania & Yusuf, Abdullahi, 2019. "Mathematical modeling for the impacts of deforestation on wildlife species using Caputo differential operator," Chaos, Solitons & Fractals, Elsevier, vol. 126(C), pages 32-40.
    11. Laarem, Guessas, 2021. "A new 4-D hyper chaotic system generated from the 3-D Rösslor chaotic system, dynamical analysis, chaos stabilization via an optimized linear feedback control, it’s fractional order model and chaos sy," Chaos, Solitons & Fractals, Elsevier, vol. 152(C).
    12. Bedilu Alamirie Ejigu & Manalebish Debalike Asfaw & Lisa Cavalerie & Tilahun Abebaw & Mark Nanyingi & Matthew Baylis, 2021. "Assessing the impact of non-pharmaceutical interventions (NPI) on the dynamics of COVID-19: A mathematical modelling study of the case of Ethiopia," PLOS ONE, Public Library of Science, vol. 16(11), pages 1-21, November.
    13. Rubayyi T. Alqahtani & Shabir Ahmad & Ali Akgül, 2021. "Mathematical Analysis of Biodegradation Model under Nonlocal Operator in Caputo Sense," Mathematics, MDPI, vol. 9(21), pages 1-21, November.
    14. Rubayyi T. Alqahtani & Shabir Ahmad & Ali Akgül, 2021. "Dynamical Analysis of Bio-Ethanol Production Model under Generalized Nonlocal Operator in Caputo Sense," Mathematics, MDPI, vol. 9(19), pages 1-21, September.
    15. Begum, Razia & Tunç, Osman & Khan, Hasib & Gulzar, Haseena & Khan, Aziz, 2021. "A fractional order Zika virus model with Mittag–Leffler kernel," Chaos, Solitons & Fractals, Elsevier, vol. 146(C).
    16. Li, Zhongfei & Liu, Zhuang & Khan, Muhammad Altaf, 2020. "Fractional investigation of bank data with fractal-fractional Caputo derivative," Chaos, Solitons & Fractals, Elsevier, vol. 131(C).
    17. Rihan, F.A. & Al-Mdallal, Q.M. & AlSakaji, H.J. & Hashish, A., 2019. "A fractional-order epidemic model with time-delay and nonlinear incidence rate," Chaos, Solitons & Fractals, Elsevier, vol. 126(C), pages 97-105.
    18. Abu Arqub, Omar & Al-Smadi, Mohammed, 2020. "An adaptive numerical approach for the solutions of fractional advection–diffusion and dispersion equations in singular case under Riesz’s derivative operator," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 540(C).
    19. Liao, Xiaozhong & Wang, Yong & Yu, Donghui & Lin, Da & Ran, Manjie & Ruan, Pengbo, 2023. "Modeling and analysis of Buck-Boost converter with non-singular fractional derivatives," Chaos, Solitons & Fractals, Elsevier, vol. 169(C).
    20. Usman Riaz & Akbar Zada & Zeeshan Ali & Ioan-Lucian Popa & Shahram Rezapour & Sina Etemad, 2021. "On a Riemann–Liouville Type Implicit Coupled System via Generalized Boundary Conditions," Mathematics, MDPI, vol. 9(11), pages 1-22, May.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:eee:chsofr:v:148:y:2021:i:c:s0960077921003908. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Thayer, Thomas R. (email available below). General contact details of provider: https://www.journals.elsevier.com/chaos-solitons-and-fractals .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.