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Numerical Modeling of Fractional-Order Biological Systems

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  • Fathalla A. Rihan

Abstract

We provide a class of fractional-order differential models of biological systems with memory, such as dynamics of tumor-immune system and dynamics of HIV infection of CD4 + T cells. Stability and nonstability conditions for disease-free equilibrium and positive equilibria are obtained in terms of a threshold parameter (minimum infection parameter) for each model. We provide unconditionally stable method, using the Caputo fractional derivative of order and implicit Euler’s approximation, to find a numerical solution of the resulting systems. The numerical simulations confirm the advantages of the numerical technique and using fractional-order differential models in biological systems over the differential equations with integer order. The results may give insight to infectious disease specialists.

Suggested Citation

  • Fathalla A. Rihan, 2013. "Numerical Modeling of Fractional-Order Biological Systems," Abstract and Applied Analysis, Hindawi, vol. 2013, pages 1-11, August.
    • Handle: RePEc:hin:jnlaaa:816803
    DOI: 10.1155/2013/816803
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    Cited by:

    1. Laarem, Guessas, 2021. "A new 4-D hyper chaotic system generated from the 3-D Rösslor chaotic system, dynamical analysis, chaos stabilization via an optimized linear feedback control, it’s fractional order model and chaos sy," Chaos, Solitons & Fractals, Elsevier, vol. 152(C).
    2. R. Rakkiyappan & V. Preethi Latha & Fathalla A. Rihan, 2019. "A Fractional-Order Model for Zika Virus Infection with Multiple Delays," Complexity, Hindawi, vol. 2019, pages 1-20, November.
    3. Agus Suryanto & Isnani Darti & Syaiful Anam, 2017. "Stability Analysis of a Fractional Order Modified Leslie-Gower Model with Additive Allee Effect," International Journal of Mathematics and Mathematical Sciences, Hindawi, vol. 2017, pages 1-9, May.
    4. Kar, Silajit & Maiti, Dilip K. & Maiti, Atasi Patra, 2024. "Impacts of non-locality and memory kernel of fractional derivative, awareness and treatment strategies on HIV/AIDS prevalence," Chaos, Solitons & Fractals, Elsevier, vol. 178(C).
    5. Agrawal, Khushbu & Kumar, Ranbir & Kumar, Sunil & Hadid, Samir & Momani, Shaher, 2022. "Bernoulli wavelet method for non-linear fractional Glucose–Insulin regulatory dynamical system," Chaos, Solitons & Fractals, Elsevier, vol. 164(C).
    6. Rihan, F.A. & Velmurugan, G., 2020. "Dynamics of fractional-order delay differential model for tumor-immune system," Chaos, Solitons & Fractals, Elsevier, vol. 132(C).
    7. Nazir, Ghazala & Shah, Kamal & Debbouche, Amar & Khan, Rahmat Ali, 2020. "Study of HIV mathematical model under nonsingular kernel type derivative of fractional order," Chaos, Solitons & Fractals, Elsevier, vol. 139(C).
    8. DAŞBAŞI, Bahatdin, 2020. "Stability analysis of the hiv model through incommensurate fractional-order nonlinear system," Chaos, Solitons & Fractals, Elsevier, vol. 137(C).
    9. Ndenda, J.P. & Njagarah, J.B.H. & Shaw, S., 2021. "Role of immunotherapy in tumor-immune interaction: Perspectives from fractional-order modelling and sensitivity analysis," Chaos, Solitons & Fractals, Elsevier, vol. 148(C).
    10. Rihan, F.A. & Al-Mdallal, Q.M. & AlSakaji, H.J. & Hashish, A., 2019. "A fractional-order epidemic model with time-delay and nonlinear incidence rate," Chaos, Solitons & Fractals, Elsevier, vol. 126(C), pages 97-105.
    11. Kumar, Sunil & Kumar, Ajay & Samet, Bessem & Gómez-Aguilar, J.F. & Osman, M.S., 2020. "A chaos study of tumor and effector cells in fractional tumor-immune model for cancer treatment," Chaos, Solitons & Fractals, Elsevier, vol. 141(C).
    12. Naim, Mouhcine & Lahmidi, Fouad & Namir, Abdelwahed & Kouidere, Abdelfatah, 2021. "Dynamics of an fractional SEIR epidemic model with infectivity in latent period and general nonlinear incidence rate," Chaos, Solitons & Fractals, Elsevier, vol. 152(C).
    13. Rihan, F.A. & Rajivganthi, C, 2020. "Dynamics of fractional-order delay differential model of prey-predator system with Holling-type III and infection among predators," Chaos, Solitons & Fractals, Elsevier, vol. 141(C).
    14. Usman Riaz & Akbar Zada & Zeeshan Ali & Ioan-Lucian Popa & Shahram Rezapour & Sina Etemad, 2021. "On a Riemann–Liouville Type Implicit Coupled System via Generalized Boundary Conditions," Mathematics, MDPI, vol. 9(11), pages 1-22, May.
    15. Naik, Parvaiz Ahmad & Zu, Jian & Owolabi, Kolade M., 2020. "Global dynamics of a fractional order model for the transmission of HIV epidemic with optimal control," Chaos, Solitons & Fractals, Elsevier, vol. 138(C).
    16. Yao, Zichen & Yang, Zhanwen & Gao, Jianfang, 2023. "Unconditional stability analysis of Grünwald Letnikov method for fractional-order delay differential equations," Chaos, Solitons & Fractals, Elsevier, vol. 177(C).
    17. Shi, Ruiqing & Lu, Ting & Wang, Cuihong, 2021. "Dynamic analysis of a fractional-order model for HIV with drug-resistance and CTL immune response," Mathematics and Computers in Simulation (MATCOM), Elsevier, vol. 188(C), pages 509-536.

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