IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0062847.html
   My bibliography  Save this article

Adoptive Cellular Immunotherapy in Metastatic Renal Cell Carcinoma: A Systematic Review and Meta-Analysis

Author

Listed:
  • Xiaoyi Tang
  • Ting Liu
  • Xuefeng Zang
  • Hao Liu
  • Danhong Wang
  • Hu Chen
  • Bin Zhang

Abstract

Purpose: Metastatic renal cell carcinoma (mRCC), as one of the most immunogenic tumors has been the focus of adoptive cellular immunotherapy (ACI), but the effects of ACI on objective response and survival in patients with mRCC are still controversial. Therefore, a systematic review and meta-analysis was performed to address this issue. Methods: A search was conducted in the PubMed database for randomized clinical trials (RCTs) with ACI in mRCC. All included articles in this study were assessed according to the selection criteria and were divided into two groups: ACI versus no ACI. Outcomes were toxicity, objective response, 1-, 3- and 5-year survival. Risk ratio (RR) and 95% confidence intervals (CI) were calculated using a fixed-effects meta-analysis. Heterogeneity was measured by value of I2 or P. Results: 4 studies (469 patients) were included. Most of ACI-related adverse reactions were grade 1 or 2 and reversible. ACI provided significant benefit in terms of objective response (RR = 1.65; 95% CI, 1.15 to 2.38; P = 0.007, I2 = 49%), 1-year survival (RR = 1.30; 95% CI, 1.12 to 1.52; P = 0.0008, I2 = 0%), 3-year survival (RR = 2.76; 95% CI, 1.85 to 4.14; P

Suggested Citation

  • Xiaoyi Tang & Ting Liu & Xuefeng Zang & Hao Liu & Danhong Wang & Hu Chen & Bin Zhang, 2013. "Adoptive Cellular Immunotherapy in Metastatic Renal Cell Carcinoma: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(5), pages 1-6, May.
    • Handle: RePEc:plo:pone00:0062847
    DOI: 10.1371/journal.pone.0062847
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0062847
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0062847&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0062847?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Ndenda, J.P. & Njagarah, J.B.H. & Shaw, S., 2021. "Role of immunotherapy in tumor-immune interaction: Perspectives from fractional-order modelling and sensitivity analysis," Chaos, Solitons & Fractals, Elsevier, vol. 148(C).
    2. Yuan Zeng & Wenli Ruan & Jiaxi He & Jianrong Zhang & Wenhua Liang & Yaoqi Chen & Qihua He & Jianxing He, 2016. "Adoptive Immunotherapy in Postoperative Non-Small-Cell Lung Cancer: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(9), pages 1-11, September.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0062847. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.