IDEAS home Printed from https://ideas.repec.org/a/eee/chsofr/v142y2021ics0960077920308754.html
   My bibliography  Save this article

The impact of distributed time delay in a tumor-immune interaction system

Author

Listed:
  • Sardar, Mrinmoy
  • Biswas, Santosh
  • Khajanchi, Subhas

Abstract

The impact of continuously distributed delay has been investigated in this paper to describe the interaction among tumor cells, tumor-specific CD8+T cells, helper T cells and immuno-stimulatory cytokine interleukin-2 (IL-2) through a system of coupled nonlinear ordinary differential equations. We analyze the qualitative properties of the model such as positivity of the solutions and the existence of biologically feasible equilibrium points. Next, we discuss the local asymptotic stability for the delayed and non-delayed system. Our model system experiences Hopf bifurcation with respect to the activation rate λ1 of tumor-specific CD8+T cells. The effect of continuously distributed delay involved in immune-activation on the system dynamics of the tumor is demonstrated. Our study reveals that the activation rate of CD8+T cells can prevent the oscillation of tumor-presence equilibria as well as tumor-free equilibria of the system. Then we performed some numerical results and interpret their biological implications to validate our analytical findings.

Suggested Citation

  • Sardar, Mrinmoy & Biswas, Santosh & Khajanchi, Subhas, 2021. "The impact of distributed time delay in a tumor-immune interaction system," Chaos, Solitons & Fractals, Elsevier, vol. 142(C).
    • Handle: RePEc:eee:chsofr:v:142:y:2021:i:c:s0960077920308754
    DOI: 10.1016/j.chaos.2020.110483
    as

    Download full text from publisher

    File URL: http://www.sciencedirect.com/science/article/pii/S0960077920308754
    Download Restriction: Full text for ScienceDirect subscribers only
    File URL: https://libkey.io/10.1016/j.chaos.2020.110483?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Khajanchi, Subhas, 2017. "Modeling the dynamics of stage-structure predator-prey system with Monod–Haldane type response function," Applied Mathematics and Computation, Elsevier, vol. 302(C), pages 122-143.
    2. Khajanchi, Subhas & Ghosh, Dibakar, 2015. "The combined effects of optimal control in cancer remission," Applied Mathematics and Computation, Elsevier, vol. 271(C), pages 375-388.
    3. Khajanchi, Subhas, 2018. "Modeling the dynamics of glioma-immune surveillance," Chaos, Solitons & Fractals, Elsevier, vol. 114(C), pages 108-118.
    4. Catherine M. Koebel & William Vermi & Jeremy B. Swann & Nadeen Zerafa & Scott J. Rodig & Lloyd J. Old & Mark J. Smyth & Robert D. Schreiber, 2007. "Adaptive immunity maintains occult cancer in an equilibrium state," Nature, Nature, vol. 450(7171), pages 903-907, December.
    5. Khajanchi, Subhas & Nieto, Juan J., 2019. "Mathematical modeling of tumor-immune competitive system, considering the role of time delay," Applied Mathematics and Computation, Elsevier, vol. 340(C), pages 180-205.
    6. Khajanchi, Subhas, 2015. "Bifurcation analysis of a delayed mathematical model for tumor growth," Chaos, Solitons & Fractals, Elsevier, vol. 77(C), pages 264-276.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Han, Haoming & Zhang, Jing & Liu, Yan, 2023. "Stability analysis of hybrid high-order nonlinear multiple time-delayed coupled systems via aperiodically intermittent control," Chaos, Solitons & Fractals, Elsevier, vol. 172(C).
    2. Khajanchi, Subhas, 2021. "The impact of immunotherapy on a glioma immune interaction model," Chaos, Solitons & Fractals, Elsevier, vol. 152(C).
    3. Sardar, Mrinmoy & Khajanchi, Subhas & Biswas, Santosh & Ghosh, Sumana, 2024. "A mathematical model for tumor-immune competitive system with multiple time delays," Chaos, Solitons & Fractals, Elsevier, vol. 179(C).
    4. Tang, Xiaosong, 2022. "Periodic solutions and spatial patterns induced by mixed delays in a diffusive spruce budworm model with Holling II predation function," Mathematics and Computers in Simulation (MATCOM), Elsevier, vol. 192(C), pages 420-429.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Khajanchi, Subhas, 2021. "The impact of immunotherapy on a glioma immune interaction model," Chaos, Solitons & Fractals, Elsevier, vol. 152(C).
    2. Khajanchi, Subhas & Nieto, Juan J., 2019. "Mathematical modeling of tumor-immune competitive system, considering the role of time delay," Applied Mathematics and Computation, Elsevier, vol. 340(C), pages 180-205.
    3. Li, Qian & Xiao, Yanni, 2019. "Bifurcation analyses and hormetic effects of a discrete-time tumor model," Applied Mathematics and Computation, Elsevier, vol. 363(C), pages 1-1.
    4. Khajanchi, Subhas & Bera, Sovan & Roy, Tapan Kumar, 2021. "Mathematical analysis of the global dynamics of a HTLV-I infection model, considering the role of cytotoxic T-lymphocytes," Mathematics and Computers in Simulation (MATCOM), Elsevier, vol. 180(C), pages 354-378.
    5. Khajanchi, Subhas, 2018. "Modeling the dynamics of glioma-immune surveillance," Chaos, Solitons & Fractals, Elsevier, vol. 114(C), pages 108-118.
    6. Liu, Yujuan & Lu, Qiong, 2020. "Hopf bifurcations in 3D competitive system with mixing exponential and rational growth rates," Applied Mathematics and Computation, Elsevier, vol. 378(C).
    7. Han, Haoming & Zhang, Jing & Liu, Yan, 2023. "Stability analysis of hybrid high-order nonlinear multiple time-delayed coupled systems via aperiodically intermittent control," Chaos, Solitons & Fractals, Elsevier, vol. 172(C).
    8. Sardar, Mrinmoy & Khajanchi, Subhas & Biswas, Santosh & Ghosh, Sumana, 2024. "A mathematical model for tumor-immune competitive system with multiple time delays," Chaos, Solitons & Fractals, Elsevier, vol. 179(C).
    9. Liu, Xiangdong & Li, Qingze & Pan, Jianxin, 2018. "A deterministic and stochastic model for the system dynamics of tumor–immune responses to chemotherapy," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 500(C), pages 162-176.
    10. D.S. Baek & T.H. Chung & Y.H. Kim & S.K. Oh & K.M. So & C. Park, 2017. "Changes in regulatory T cells in dogs with B-cell lymphoma and association with clinical tumour stage," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 62(12), pages 647-653.
    11. Khajanchi, Subhas & Ghosh, Dibakar, 2015. "The combined effects of optimal control in cancer remission," Applied Mathematics and Computation, Elsevier, vol. 271(C), pages 375-388.
    12. Zhao, Zhong & Pang, Liuyong & Li, Qiuying, 2021. "Analysis of a hybrid impulsive tumor-immune model with immunotherapy and chemotherapy," Chaos, Solitons & Fractals, Elsevier, vol. 144(C).
    13. Thomas Thisted & F. Donelson Smith & Arnab Mukherjee & Yuliya Kleschenko & Feng Feng & Zhi-Gang Jiang & Timothy Eitas & Kanam Malhotra & Zuzana Biesova & Adejumoke Onumajuru & Faith Finley & Anokhi Ci, 2024. "VISTA checkpoint inhibition by pH-selective antibody SNS-101 with optimized safety and pharmacokinetic profiles enhances PD-1 response," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    14. Maiti, Atasi Patra & Dubey, B. & Chakraborty, A., 2019. "Global analysis of a delayed stage structure prey–predator model with Crowley–Martin type functional response," Mathematics and Computers in Simulation (MATCOM), Elsevier, vol. 162(C), pages 58-84.
    15. Das, Parthasakha & Das, Pritha & Mukherjee, Sayan, 2020. "Stochastic dynamics of Michaelis–Menten kinetics based tumor-immune interactions," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 541(C).
    16. El-Mesady, A. & Ali, Hegagi Mohamed, 2024. "The influence of prevention and isolation measures to control the infections of the fractional Chickenpox disease model," Mathematics and Computers in Simulation (MATCOM), Elsevier, vol. 226(C), pages 606-630.
    17. Dzyubak, Larysa & Dzyubak, Oleksandr & Awrejcewicz, Jan, 2023. "Nonlinear multiscale diffusion cancer invasion model with memory of states," Chaos, Solitons & Fractals, Elsevier, vol. 168(C).
    18. Bera, Sovan & Khajanchi, Subhas & Roy, Tapan Kumar, 2022. "Dynamics of an HTLV-I infection model with delayed CTLs immune response," Applied Mathematics and Computation, Elsevier, vol. 430(C).
    19. Khajanchi, Subhas & Das, Dhiraj Kumar & Kar, Tapan Kumar, 2018. "Dynamics of tuberculosis transmission with exogenous reinfections and endogenous reactivation," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 497(C), pages 52-71.
    20. Yousefpour, Amin & Jahanshahi, Hadi & Bekiros, Stelios, 2020. "Optimal policies for control of the novel coronavirus disease (COVID-19) outbreak," Chaos, Solitons & Fractals, Elsevier, vol. 136(C).

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:eee:chsofr:v:142:y:2021:i:c:s0960077920308754. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Thayer, Thomas R. (email available below). General contact details of provider: https://www.journals.elsevier.com/chaos-solitons-and-fractals .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.