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Adaptive immunity maintains occult cancer in an equilibrium state

Author

Listed:
  • Catherine M. Koebel

    (Washington University School of Medicine, St. Louis, Missouri 63110, USA)

  • William Vermi

    (Washington University School of Medicine, St. Louis, Missouri 63110, USA
    University of Brescia/Spedali Civili di Brescia)

  • Jeremy B. Swann

    (Cancer Immunology Program, Sir Donald and Lady Trescowthick Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia
    University of Melbourne, Parkville, Victoria 3010, Australia)

  • Nadeen Zerafa

    (Cancer Immunology Program, Sir Donald and Lady Trescowthick Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia)

  • Scott J. Rodig

    (Brigham and Women’s Hospital Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Lloyd J. Old

    (Ludwig Institute for Cancer Research at Memorial Sloan Kettering Cancer Center)

  • Mark J. Smyth

    (Cancer Immunology Program, Sir Donald and Lady Trescowthick Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia
    University of Melbourne, Parkville, Victoria 3010, Australia)

  • Robert D. Schreiber

    (Washington University School of Medicine, St. Louis, Missouri 63110, USA)

Abstract

Tumours are occasionally transferred from donor to recipients during organ transplantation. This paper shows in a mouse model that during latency tumours are actively held in check by the adaptive immune system.

Suggested Citation

  • Catherine M. Koebel & William Vermi & Jeremy B. Swann & Nadeen Zerafa & Scott J. Rodig & Lloyd J. Old & Mark J. Smyth & Robert D. Schreiber, 2007. "Adaptive immunity maintains occult cancer in an equilibrium state," Nature, Nature, vol. 450(7171), pages 903-907, December.
    • Handle: RePEc:nat:nature:v:450:y:2007:i:7171:d:10.1038_nature06309
    DOI: 10.1038/nature06309
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    Citations

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    Cited by:

    1. Das, Parthasakha & Mukherjee, Sayan & Das, Pritha, 2019. "An investigation on Michaelis - Menten kinetics based complex dynamics of tumor - immune interaction," Chaos, Solitons & Fractals, Elsevier, vol. 128(C), pages 297-305.
    2. D.S. Baek & T.H. Chung & Y.H. Kim & S.K. Oh & K.M. So & C. Park, 2017. "Changes in regulatory T cells in dogs with B-cell lymphoma and association with clinical tumour stage," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 62(12), pages 647-653.
    3. Yau-Hua Yu & Hsu-Ko Kuo & Kuo-Wei Chang, 2008. "The Evolving Transcriptome of Head and Neck Squamous Cell Carcinoma: A Systematic Review," PLOS ONE, Public Library of Science, vol. 3(9), pages 1-11, September.
    4. Das, Parthasakha & Das, Pritha & Mukherjee, Sayan, 2020. "Stochastic dynamics of Michaelis–Menten kinetics based tumor-immune interactions," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 541(C).
    5. Thomas Thisted & F. Donelson Smith & Arnab Mukherjee & Yuliya Kleschenko & Feng Feng & Zhi-Gang Jiang & Timothy Eitas & Kanam Malhotra & Zuzana Biesova & Adejumoke Onumajuru & Faith Finley & Anokhi Ci, 2024. "VISTA checkpoint inhibition by pH-selective antibody SNS-101 with optimized safety and pharmacokinetic profiles enhances PD-1 response," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    6. Louise A. Baldwin & Nenad Bartonicek & Jessica Yang & Sunny Z. Wu & Niantao Deng & Daniel L. Roden & Chia-Ling Chan & Ghamdan Al-Eryani & Damien J. Zanker & Belinda S. Parker & Alexander Swarbrick & S, 2022. "DNA barcoding reveals ongoing immunoediting of clonal cancer populations during metastatic progression and immunotherapy response," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    7. Sardar, Mrinmoy & Biswas, Santosh & Khajanchi, Subhas, 2021. "The impact of distributed time delay in a tumor-immune interaction system," Chaos, Solitons & Fractals, Elsevier, vol. 142(C).

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