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Role of herbal medicine for controlling coronavirus (SARS-CoV-2) disease (COVID-19)

Author

Listed:
  • Ravindra B. Malabadi

    (Department of Applied Botany, Mangalore University, Mangalagangotri-574199, Mangalore, Karnataka State, India)

  • Neelambika T. Meti

    (Plant Biotechnology Laboratory, Rajiv Gandhi Institute of IT and Biotechnology, Bharati Vidyapeeth University, Pune-Satara Road, Katraj, Pune – 411046, Maharashtra State, India)

  • Raju K. Chalannavar

    (Department of Applied Botany, Mangalore University, Mangalagangotri-574199, Mangalore, Karnataka State, India)

Abstract

This review paper highlights the use of herbal medicine in the management of the coronavirus disease COVID-19 (SARS-CoV-2) pandemic, which has caused a worldwide outbreak of respiratory illness. This is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which is zoonotic infecting both animal and human. Vaccines are the most promising solution to mitigate new viral strains. The Indian system of holistic medicine known as “Ayurveda†plays an important role in controling the viral disease SARS-CoV-2 and other health disorders. Dietary therapy and herbal medicine could be a complementary preventive therapy for COVID-19 (SARS-CoV-2). Plants have been used as a expression systems for the production of diagnostic reagents and pharmaceutical proteins often described as ‘molecular farming. On the basis of literature survy presented, some of the plant secondary metabolites that showed prominent antiviral activity against coronaviruses SARS-CoV-2 through impeding the main machinery used in their pathogenesis and replication cycle. The in vitro, in vivo, and in silico investigations revealed numerous plant-derived compounds with promising anti- SARS-CoV and anti- SARS CoV-2 activity. Therefore, this review gathered all antiviral plants in a single platform to facilitate the laboratory-based research for the development of novel drug/molecular therapeutics to overcome the SARS-CoV-2 and future pandemic situations. Further detailed clinical trial experiments should be conducted for the scientific validation.

Suggested Citation

  • Ravindra B. Malabadi & Neelambika T. Meti & Raju K. Chalannavar, 2021. "Role of herbal medicine for controlling coronavirus (SARS-CoV-2) disease (COVID-19)," International Journal of Research and Scientific Innovation, International Journal of Research and Scientific Innovation (IJRSI), vol. 8(2), pages 135-165, February.
    • Handle: RePEc:bjc:journl:v:8:y:2021:i:2:p:135-165
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    References listed on IDEAS

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    1. Jing-Hui Tian & Nita Patel & Robert Haupt & Haixia Zhou & Stuart Weston & Holly Hammond & James Logue & Alyse D. Portnoff & James Norton & Mimi Guebre-Xabier & Bin Zhou & Kelsey Jacobson & Sonia Macie, 2021. "SARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 immunogenicity in baboons and protection in mice," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    2. Wenhui Li & Michael J. Moore & Natalya Vasilieva & Jianhua Sui & Swee Kee Wong & Michael A. Berne & Mohan Somasundaran & John L. Sullivan & Katherine Luzuriaga & Thomas C. Greenough & Hyeryun Choe & M, 2003. "Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus," Nature, Nature, vol. 426(6965), pages 450-454, November.
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