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Viral Pandemics of the Last Four Decades: Pathophysiology, Health Impacts and Perspectives

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  • Shubhadeep Roychoudhury

    (Department of Life Science and Bioinformatics, Assam University, Silchar 788011, India)

  • Anandan Das

    (Department of Life Science and Bioinformatics, Assam University, Silchar 788011, India)

  • Pallav Sengupta

    (Department of Physiology, Faculty of Medicine and Biomedical Sciences, MAHSA University, SP2, Bandar Saujana Putra, Jenjarom, Selangor 42610, Malaysia)

  • Sulagna Dutta

    (Department of Oral Biology and Biomedical Sciences, Faculty of Dentistry, MAHSA University, SP2, Bandar Saujana Putra, Jenjarom, Selangor 42610, Malaysia)

  • Shatabhisha Roychoudhury

    (Department of Microbiology, R. G. Kar Medical College and Hospital, Kolkata 700004, India
    Health Centre, Assam University, Silchar 788011, India)

  • Arun Paul Choudhury

    (Department of Obstetrics and Gynecology, Silchar Medical College and Hospital, Silchar 788014, India)

  • A. B. Fuzayel Ahmed

    (Department of Obstetrics and Gynecology, Silchar Medical College and Hospital, Silchar 788014, India)

  • Saumendra Bhattacharjee

    (Department of Pathology, Silchar Medical College and Hospital, Silchar 788014, India)

  • Petr Slama

    (Department of Animal Morphology, Physiology and Genetics, Faculty of AgriSciences, Mendel University in Brno, Zemedelska 1, 613 00 Brno, Czech Republic)

Abstract

The last four decades has witnessed some of the deadliest viral pandemics with far-reaching consequences. These include the Human Immunodeficiency Virus (HIV) (1981), Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) (2002), Influenza A virus subtype H1N1 (A/H1N1) (2009), Middle East Respiratory Syndrome Coronavirus (MERS-CoV) (2012), Ebola virus (2013) and the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) (2019-present). Age- and gender-based characterizations suggest that SARS-CoV-2 resembles SARS-CoV and MERS-CoV with regard to higher fatality rates in males, and in the older population with comorbidities. The invasion-mechanism of SARS-CoV-2 and SARS-CoV, involves binding of its spike protein with angiotensin-converting enzyme 2 (ACE2) receptors; MERS-CoV utilizes dipeptidyl peptidase 4 (DPP4), whereas H1N1 influenza is equipped with hemagglutinin protein. The viral infections-mediated immunomodulation, and progressive inflammatory state may affect the functions of several other organs. Although no effective commercial vaccine is available for any of the viruses, those against SARS-CoV-2 are being developed at an unprecedented speed. Until now, only Pfizer/BioNTech’s vaccine has received temporary authorization from the UK Medicines and Healthcare products Regulatory Agency. Given the frequent emergence of viral pandemics in the 21st century, proper understanding of their characteristics and modes of action are essential to address the immediate and long-term health consequences.

Suggested Citation

  • Shubhadeep Roychoudhury & Anandan Das & Pallav Sengupta & Sulagna Dutta & Shatabhisha Roychoudhury & Arun Paul Choudhury & A. B. Fuzayel Ahmed & Saumendra Bhattacharjee & Petr Slama, 2020. "Viral Pandemics of the Last Four Decades: Pathophysiology, Health Impacts and Perspectives," IJERPH, MDPI, vol. 17(24), pages 1-39, December.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:24:p:9411-:d:462604
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    1. Noe B. Mercado & Roland Zahn & Frank Wegmann & Carolin Loos & Abishek Chandrashekar & Jingyou Yu & Jinyan Liu & Lauren Peter & Katherine McMahan & Lisa H. Tostanoski & Xuan He & David R. Martinez & Lu, 2020. "Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques," Nature, Nature, vol. 586(7830), pages 583-588, October.
    2. Rasmussen, S.A. & Jamieson, D.J. & MacFarlane, K. & Cragan, J.D. & Williams, J. & Henderson, Z., 2009. "Pandemic influenza and pregnant women: Summary of a meeting of experts," American Journal of Public Health, American Public Health Association, vol. 99(S2), pages 248-254.
    3. Wenhui Li & Michael J. Moore & Natalya Vasilieva & Jianhua Sui & Swee Kee Wong & Michael A. Berne & Mohan Somasundaran & John L. Sullivan & Katherine Luzuriaga & Thomas C. Greenough & Hyeryun Choe & M, 2003. "Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus," Nature, Nature, vol. 426(6965), pages 450-454, November.
    4. V. Stalin Raj & Huihui Mou & Saskia L. Smits & Dick H. W. Dekkers & Marcel A. Müller & Ronald Dijkman & Doreen Muth & Jeroen A. A. Demmers & Ali Zaki & Ron A. M. Fouchier & Volker Thiel & Christian Dr, 2013. "Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC," Nature, Nature, vol. 495(7440), pages 251-254, March.
    5. Quinn, S.C. & Kumar, S. & Freimuth, V.S. & Musa, D. & Casteneda-Angarita, N. & Kidwell, K., 2011. "Racial disparities in exposure, susceptibility, and access to health care in the US H1N1 influenza pandemic," American Journal of Public Health, American Public Health Association, vol. 101(2), pages 285-293.
    6. Walter Leal Filho & Luciana Londero Brandli & Amanda Lange Salvia & Lez Rayman-Bacchus & Johannes Platje, 2020. "COVID-19 and the UN Sustainable Development Goals: Threat to Solidarity or an Opportunity?," Sustainability, MDPI, vol. 12(13), pages 1-14, July.
    7. Francesco Di Gennaro & Damiano Pizzol & Claudia Marotta & Mario Antunes & Vincenzo Racalbuto & Nicola Veronese & Lee Smith, 2020. "Coronavirus Diseases (COVID-19) Current Status and Future Perspectives: A Narrative Review," IJERPH, MDPI, vol. 17(8), pages 1-11, April.
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