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Tests for High Dimensional Generalized Linear Models

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  • Chen, Song Xi
  • Guo, Bin

Abstract

We consider testing regression coefficients in high dimensional generalized linear models. By modifying a test statistic proposed by Goeman et al. (2011) for large but fixed dimensional settings, we propose a new test which is applicable for diverging dimension and is robust for a wide range of link functions. The power properties of the tests are evaluated under the setting of the local and fixed alternatives. A test in the presence of nuisance parameters is also proposed. The proposed tests can provide p-values for testing significance of multiple gene-sets, whose usefulness is demonstrated in a case study on an acute lymphoblastic leukemia dataset.

Suggested Citation

  • Chen, Song Xi & Guo, Bin, 2014. "Tests for High Dimensional Generalized Linear Models," MPRA Paper 59816, University Library of Munich, Germany.
    • Handle: RePEc:pra:mprapa:59816
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    References listed on IDEAS

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    1. Jelle J. Goeman & Sara A. Van De Geer & Hans C. Van Houwelingen, 2006. "Testing against a high dimensional alternative," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 68(3), pages 477-493, June.
    2. Chen, Song Xi & Zhang, Li-Xin & Zhong, Ping-Shou, 2010. "Tests for High-Dimensional Covariance Matrices," Journal of the American Statistical Association, American Statistical Association, vol. 105(490), pages 810-819.
    3. Wei Lan & Hansheng Wang & Chih-Ling Tsai, 2014. "Testing covariates in high-dimensional regression," Annals of the Institute of Statistical Mathematics, Springer;The Institute of Statistical Mathematics, vol. 66(2), pages 279-301, April.
    4. Jelle J. Goeman & Hans C. van Houwelingen & Livio Finos, 2011. "Testing against a high-dimensional alternative in the generalized linear model: asymptotic type I error control," Biometrika, Biometrika Trust, vol. 98(2), pages 381-390.
    5. Chen, Songxi, 2012. "Two Sample Tests for High Dimensional Covariance Matrices," MPRA Paper 46026, University Library of Munich, Germany.
    6. Song Xi Chen & Liang Peng & Ying-Li Qin, 2009. "Effects of data dimension on empirical likelihood," Biometrika, Biometrika Trust, vol. 96(3), pages 711-722.
    7. Patrick Danaher & Pei Wang & Daniela M. Witten, 2014. "The joint graphical lasso for inverse covariance estimation across multiple classes," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 76(2), pages 373-397, March.
    8. Jianqing Fan & Jinchi Lv, 2008. "Sure independence screening for ultrahigh dimensional feature space," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 70(5), pages 849-911, November.
    9. Zhong, Ping-Shou & Chen, Song Xi, 2011. "Tests for High-Dimensional Regression Coefficients With Factorial Designs," Journal of the American Statistical Association, American Statistical Association, vol. 106(493), pages 260-274.
    10. Vaart,A. W. van der, 2000. "Asymptotic Statistics," Cambridge Books, Cambridge University Press, number 9780521784504, September.
    11. Chen, Song Xi & Qin, Yingli, 2010. "A Two Sample Test for High Dimensional Data with Applications to Gene-set Testing," MPRA Paper 59642, University Library of Munich, Germany.
    12. John D. Storey & Jonathan E. Taylor & David Siegmund, 2004. "Strong control, conservative point estimation and simultaneous conservative consistency of false discovery rates: a unified approach," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 66(1), pages 187-205, February.
    13. Cun-Hui Zhang & Stephanie S. Zhang, 2014. "Confidence intervals for low dimensional parameters in high dimensional linear models," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 76(1), pages 217-242, January.
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    Cited by:

    1. Liu, Yan & Zhang, Sanguo & Ma, Shuangge & Zhang, Qingzhao, 2020. "Tests for regression coefficients in high dimensional partially linear models," Statistics & Probability Letters, Elsevier, vol. 163(C).
    2. Sardy, Sylvain & Diaz-Rodriguez, Jairo & Giacobino, Caroline, 2022. "Thresholding tests based on affine LASSO to achieve non-asymptotic nominal level and high power under sparse and dense alternatives in high dimension," Computational Statistics & Data Analysis, Elsevier, vol. 173(C).
    3. Simona Catuogno & Claudia Arena & Sara Saggese & Fabrizia Sarto, 2016. "The Influence of Blockholders, Bondholders and Families on the Venturers’ Accounting Behavior," International Journal of Business and Management, Canadian Center of Science and Education, vol. 11(8), pages 1-31, July.
    4. Chen, Zhao & Cheng, Vivian Xinyi & Liu, Xu, 2024. "Hypothesis testing on high dimensional quantile regression," Journal of Econometrics, Elsevier, vol. 238(1).
    5. Feng, Long & Zhang, Xiaoxu & Liu, Binghui, 2020. "Multivariate tests of independence and their application in correlation analysis between financial markets," Journal of Multivariate Analysis, Elsevier, vol. 179(C).
    6. Liu, Yang & Sun, Wei & Hsu, Li & He, Qianchuan, 2022. "Statistical inference for high-dimensional pathway analysis with multiple responses," Computational Statistics & Data Analysis, Elsevier, vol. 169(C).
    7. He, Yi & Jaidee, Sombut & Gao, Jiti, 2023. "Most powerful test against a sequence of high dimensional local alternatives," Journal of Econometrics, Elsevier, vol. 234(1), pages 151-177.
    8. Chen, Zhao & Cheng, Vivian Xinyi & Liu, Xu, 2024. "Reprint: Hypothesis testing on high dimensional quantile regression," Journal of Econometrics, Elsevier, vol. 239(2).
    9. Yi He & Sombut Jaidee & Jiti Gao, 2020. "Most Powerful Test against High Dimensional Free Alternatives," Monash Econometrics and Business Statistics Working Papers 13/20, Monash University, Department of Econometrics and Business Statistics.
    10. Zhou, Ping & Yu, Zhen & Ma, Jingyi & Tian, Maozai & Fan, Ye, 2021. "Communication-efficient distributed estimator for generalized linear models with a diverging number of covariates," Computational Statistics & Data Analysis, Elsevier, vol. 157(C).

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    More about this item

    Keywords

    Generalized Linear Model; Gene-Sets; High Dimensional Covariate; Nuisance Parameter; U-statistics.;
    All these keywords.

    JEL classification:

    • C3 - Mathematical and Quantitative Methods - - Multiple or Simultaneous Equation Models; Multiple Variables
    • C30 - Mathematical and Quantitative Methods - - Multiple or Simultaneous Equation Models; Multiple Variables - - - General
    • C4 - Mathematical and Quantitative Methods - - Econometric and Statistical Methods: Special Topics
    • C5 - Mathematical and Quantitative Methods - - Econometric Modeling

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