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A Two Sample Test for High Dimensional Data with Applications to Gene-set Testing

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  • Chen, Song Xi
  • Qin, Yingli

Abstract

We proposed a two sample test for means of high dimensional data when the data dimension is much larger than the sample size. The classical Hotelling's $T^2$ test does not work for this ``large p, small n" situation. The proposed test does not require explicit conditions on the relationship between the data dimension and sample size. This offers much flexibility in analyzing high dimensional data. An application of the proposed test is in testing significance for sets of genes, which we demonstrate in an empirical study on a Leukemia data set.

Suggested Citation

  • Chen, Song Xi & Qin, Yingli, 2010. "A Two Sample Test for High Dimensional Data with Applications to Gene-set Testing," MPRA Paper 59642, University Library of Munich, Germany.
    • Handle: RePEc:pra:mprapa:59642
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    File URL: https://mpra.ub.uni-muenchen.de/59642/1/MPRA_paper_59642.pdf
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    References listed on IDEAS

    as
    1. John D. Storey & Jonathan E. Taylor & David Siegmund, 2004. "Strong control, conservative point estimation and simultaneous conservative consistency of false discovery rates: a unified approach," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 66(1), pages 187-205, February.
    2. James R. Schott, 2005. "Testing for complete independence in high dimensions," Biometrika, Biometrika Trust, vol. 92(4), pages 951-956, December.
    3. Fan, Jianqing & Hall, Peter & Yao, Qiwei, 2007. "To How Many Simultaneous Hypothesis Tests Can Normal, Student's t or Bootstrap Calibration Be Applied?," Journal of the American Statistical Association, American Statistical Association, vol. 102, pages 1282-1288, December.
    4. Fan, Jianqing & Peng, Heng & Huang, Tao, 2005. "Semilinear High-Dimensional Model for Normalization of Microarray Data: A Theoretical Analysis and Partial Consistency," Journal of the American Statistical Association, American Statistical Association, vol. 100, pages 781-796, September.
    5. Huang, Jian & Wang, Deli & Zhang, Cun-Hui, 2005. "A Two-Way Semilinear Model for Normalization and Analysis of cDNA Microarray Data," Journal of the American Statistical Association, American Statistical Association, vol. 100, pages 814-829, September.
    Full references (including those not matched with items on IDEAS)

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    More about this item

    Keywords

    large p small n; martingale central limit theorem; multiple comparison.;
    All these keywords.

    JEL classification:

    • C1 - Mathematical and Quantitative Methods - - Econometric and Statistical Methods and Methodology: General
    • C12 - Mathematical and Quantitative Methods - - Econometric and Statistical Methods and Methodology: General - - - Hypothesis Testing: General
    • C14 - Mathematical and Quantitative Methods - - Econometric and Statistical Methods and Methodology: General - - - Semiparametric and Nonparametric Methods: General

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