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Models of Neurotoxicity: Extrapolation of Benchmark Doses in Vitro

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  • Matteo Goldoni
  • Maria Vittoria Vettori
  • Rossella Alinovi
  • Andrea Caglieri
  • Sandra Ceccatelli
  • Antonio Mutti

Abstract

In risk assessment, no observed exposure level (NOAEL) and benchmark dose (BMD) are usually derived either from epidemiological studies in humans or from animal experiments. In many in vitro studies, concentration‐effect/response curves have been analyzed using different mathematical models finalized to the identification of EC50. In the present article, we propose a model to fit dose‐response curves in vitro. The BMD approach has been used to compare the cell viability (MTT assay) of different rat (C6 and PC12, glial and neuronal, respectively) and human cell lines (D384 and SK‐N‐MC, glial and neuronal, respectively) after 24‐hour exposure to the following neurotoxic substances: manganese chloride (MnCl2), methyl‐mercury (Me‐Hg), and the enantiomers of styrene oxide (SO). For all rat and human cell lines, the potency of the examined compounds was: MnCl2

Suggested Citation

  • Matteo Goldoni & Maria Vittoria Vettori & Rossella Alinovi & Andrea Caglieri & Sandra Ceccatelli & Antonio Mutti, 2003. "Models of Neurotoxicity: Extrapolation of Benchmark Doses in Vitro," Risk Analysis, John Wiley & Sons, vol. 23(3), pages 505-514, June.
    • Handle: RePEc:wly:riskan:v:23:y:2003:i:3:p:505-514
    DOI: 10.1111/1539-6924.00331
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    References listed on IDEAS

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    1. Kenny S. Crump, 1995. "Calculation of Benchmark Doses from Continuous Data," Risk Analysis, John Wiley & Sons, vol. 15(1), pages 79-89, February.
    2. R. Webster West & Ralph L. Kodell, 1999. "A Comparison of Methods of Benchmark‐Dose Estimation for Continuous Response Data," Risk Analysis, John Wiley & Sons, vol. 19(3), pages 453-459, June.
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