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Dermal Uptake of Organic Chemicals from a Soil Matrix

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  • Thomas E. McKone

Abstract

Uptake of chemicals from soil on human skin is considered. Based on a review of literature on the structure of human skin, the processes by which chemicals pass through this boundary, and experiments that reveal the rate and magnitude of this transport process; a two‐layer model is presented for estimating how chemical uptake through the stratum corneum depends on chemical properties, skin properties, soil properties and exposure conditions. The model is applied to two limiting scenarios—(1) continuous deposition and removal of soil on the skin surface and (2) a one‐time deposition of soil onto the skin surface. The fraction of soil‐bound chemical that passes through the stratum corneum is dependent on the skin‐soil layer thickness; the dimensionless Henry's law constant, Kh and the octanol‐water partition coefficient, Kow of the soil‐bound chemical. The nature of this dependence is discussed.

Suggested Citation

  • Thomas E. McKone, 1990. "Dermal Uptake of Organic Chemicals from a Soil Matrix," Risk Analysis, John Wiley & Sons, vol. 10(3), pages 407-419, September.
    • Handle: RePEc:wly:riskan:v:10:y:1990:i:3:p:407-419
    DOI: 10.1111/j.1539-6924.1990.tb00524.x
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    References listed on IDEAS

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    1. John K. Hawley, 1985. "Assessment of Health Risk from Exposure to Contaminated Soil," Risk Analysis, John Wiley & Sons, vol. 5(4), pages 289-302, December.
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    Cited by:

    1. David E. Burmaster & Nancy Irwin Maxwell, 1991. "Time‐ and Loading‐Dependence in the McKone Model for Dermal Uptake of Organic Chemicals from a Soil Matrix," Risk Analysis, John Wiley & Sons, vol. 11(3), pages 491-497, September.
    2. Kimberly M. Thompson & David E. Burmaster & Edmund A.C. Crouch3, 1992. "Monte Carlo Techniques for Quantitative Uncertainty Analysis in Public Health Risk Assessments," Risk Analysis, John Wiley & Sons, vol. 12(1), pages 53-63, March.
    3. Thomas E. McKone & Robert A. Howd, 1992. "Estimating Dermal Uptake of Nonionic Organic Chemicals from Water and Soil: I. Unified Fugacity‐Based Models for Risk Assessments," Risk Analysis, John Wiley & Sons, vol. 12(4), pages 543-557, December.
    4. Thomas E. McKone, 1991. "Human Exposure to Chemicals from Multiple Media and through Multiple Pathways: Research Overview and Comments," Risk Analysis, John Wiley & Sons, vol. 11(1), pages 5-10, March.
    5. Brent L. Finley & Paul K. Scott & Douglas A. Mayhall, 1994. "Development of a Standard Soil‐to‐Skin Adherence Probability Density Function for Use in Monte Carlo Analyses of Dermal Exposure," Risk Analysis, John Wiley & Sons, vol. 14(4), pages 555-569, August.

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