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Firm Heterogeneity in Biotech: Absorptive Capacity, Strategies and Local-Regional Connections

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  • Sharmistha Bagchi-Sen
  • Helen Lawton Smith

Abstract

This paper focuses on the characteristics of biotech firms with various levels of research and development (R&D) activity. It is done by exploring the relationship between R&D intensity, alliances and the extent of regionalization of firms' activities using evidence from a survey of US-based biotechnology firms. We profile two firm prototypes: research-oriented firms and product-oriented firms, focusing on their characteristics, strategies and operations. These include activities devoted to exploration and exploitation through alliances with universities (more exploration) and with pharmaceutical companies (exploration and exploitation), and locational needs which facilitate both exploration and exploitation.

Suggested Citation

  • Sharmistha Bagchi-Sen & Helen Lawton Smith, 2014. "Firm Heterogeneity in Biotech: Absorptive Capacity, Strategies and Local-Regional Connections," European Planning Studies, Taylor & Francis Journals, vol. 22(9), pages 1783-1801, September.
    • Handle: RePEc:taf:eurpls:v:22:y:2014:i:9:p:1783-1801
    DOI: 10.1080/09654313.2013.801572
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    1. Lin, Bou-Wen & Lee, Yikuan & Hung, Shih-Chang, 2006. "R&D intensity and commercialization orientation effects on financial performance," Journal of Business Research, Elsevier, vol. 59(6), pages 679-685, June.
    2. Philip Cooke, 2002. "Biotechnology Clusters as Regional, Sectoral Innovation Systems," International Regional Science Review, , vol. 25(1), pages 8-37, January.
    3. Gans, Joshua S. & Stern, Scott, 2003. "The product market and the market for "ideas": commercialization strategies for technology entrepreneurs," Research Policy, Elsevier, vol. 32(2), pages 333-350, February.
    4. David B. Audretsch & Paula E. Stephan, 1999. "Knowledge spillovers in biotechnology: sources and incentives," Journal of Evolutionary Economics, Springer, vol. 9(1), pages 97-107.
    5. Walter Powell & Kenneth Koput & James Bowie & Laurel Smith-Doerr, 2002. "The Spatial Clustering of Science and Capital: Accounting for Biotech Firm-Venture Capital Relationships," Regional Studies, Taylor & Francis Journals, vol. 36(3), pages 291-305.
    6. Kim, Chang-Su & Inkpen, Andrew C., 2005. "Cross-border R&D alliances, absorptive capacity and technology learning," Journal of International Management, Elsevier, vol. 11(3), pages 313-329, September.
    7. Philip Cooke, 2004. "The Molecular Biology Revolution and the Rise of Bioscience Megacentres in North America and Europe," Environment and Planning C, , vol. 22(2), pages 161-177, April.
    8. C. Autant-Bernard & V. Mangematin & N. Massard, 2006. "Creation of Biotech SMEs in France," Small Business Economics, Springer, vol. 26(2), pages 173-187, March.
    9. Mitchell P. Koza & Arie Y. Lewin, 1998. "The Co-Evolution of Strategic Alliances," Organization Science, INFORMS, vol. 9(3), pages 255-264, June.
    10. C. Autant-Bernard & V. Mangematin & N. Massard, 2006. "Creation of Biotech SMEs in France," Small Business Economics, Springer, vol. 26(2), pages 173-187, March.
    11. Anoop Madhok & Thomas Osegowitsch, 2000. "The International Biotechnology Industry: A Dynamic Capabilities Perspective," Journal of International Business Studies, Palgrave Macmillan;Academy of International Business, vol. 31(2), pages 325-335, June.
    12. Peter J. Lane & Michael Lubatkin, 1998. "Relative absorptive capacity and interorganizational learning," Post-Print hal-02311860, HAL.
    13. Pisano, Gary P., 1991. "The governance of innovation: Vertical integration and collaborative arrangements in the biotechnology industry," Research Policy, Elsevier, vol. 20(3), pages 237-249, June.
    14. Philip Cooke, 2005. "Rational drug design, the knowledge value chain and bioscience megacentres," Cambridge Journal of Economics, Cambridge Political Economy Society, vol. 29(3), pages 325-341, May.
    15. Greis, Noel P. & Dibner, Mark D. & Bean, Alden S., 1995. "External partnering as a response to innovation barriers and global competition in biotechnology," Research Policy, Elsevier, vol. 24(4), pages 609-630, July.
    16. Michelle Gittelman & Bruce Kogut, 2003. "Does Good Science Lead to Valuable Knowledge? Biotechnology Firms and the Evolutionary Logic of Citation Patterns," Management Science, INFORMS, vol. 49(4), pages 366-382, April.
    17. Frans A. J. Van den Bosch & Henk W. Volberda & Michiel de Boer, 1999. "Coevolution of Firm Absorptive Capacity and Knowledge Environment: Organizational Forms and Combinative Capabilities," Organization Science, INFORMS, vol. 10(5), pages 551-568, October.
    18. Frank T. Rothaermel & David L. Deeds, 2004. "Exploration and exploitation alliances in biotechnology: a system of new product development," Strategic Management Journal, Wiley Blackwell, vol. 25(3), pages 201-221, March.
    19. Lee, Cheng-Wen, 2007. "Strategic alliances influence on small and medium firm performance," Journal of Business Research, Elsevier, vol. 60(7), pages 731-741, July.
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