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The Economic Geography Of Knowledge Flow Hierarchies Among Internationally Networked Medical Bioclusters: A Scientometric Analysis

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  • PHILIP COOKE

Abstract

This paper builds on a suite of research studies examining the metamorphosis in industry organisation, as Penrose calls it, regarding the centrality of firm capabilities in biosciences. Whereas knowledge leadership capabilities used to be inside global corporations now they have given way to university laboratories and dedicated biotechnology firm networks to access innovative research. The basic argument is that research centre and small firm knowledge capabilities have generally outstripped those of the multinationals in knowledge‐intensive industry, a consequence of which is a re‐alignment in cause‐and‐effect outcomes shaping economic geography. This is particularly pronounced in biosciences and pharmaceuticals. The paper mobilises a new theoretical framework and new data that support the thesis that a realignment of industry organisation around knowledge capabilities was pioneered in biosciences, is active in other industries, and biosciences is now entering a new phase. This mirrors a rise in systems biology that re‐asserts the dominance of key nodes in global bioeconomy hierarchies.

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  • Philip Cooke, 2009. "The Economic Geography Of Knowledge Flow Hierarchies Among Internationally Networked Medical Bioclusters: A Scientometric Analysis," Tijdschrift voor Economische en Sociale Geografie, Royal Dutch Geographical Society KNAG, vol. 100(3), pages 332-347, July.
    • Handle: RePEc:bla:tvecsg:v:100:y:2009:i:3:p:332-347
    DOI: 10.1111/j.1467-9663.2009.00506.x
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    References listed on IDEAS

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    1. Philip Cooke, 2002. "Biotechnology Clusters as Regional, Sectoral Innovation Systems," International Regional Science Review, , vol. 25(1), pages 8-37, January.
    2. Feldman, Maryann P. & Audretsch, David B., 1999. "Innovation in cities:: Science-based diversity, specialization and localized competition," European Economic Review, Elsevier, vol. 43(2), pages 409-429, February.
    3. Glaeser, Edward L & Hedi D. Kallal & Jose A. Scheinkman & Andrei Shleifer, 1992. "Growth in Cities," Journal of Political Economy, University of Chicago Press, vol. 100(6), pages 1126-1152, December.
      • Edward L. Glaeser & Hedi D. Kallal & Jose A. Scheinkman & Andrei Shleifer, 1991. "Growth in Cities," NBER Working Papers 3787, National Bureau of Economic Research, Inc.
      • Glaeser, Edward Ludwig & Kallal, Hedi D. & Scheinkman, Jose A. & Shleifer, Andrei, 1992. "Growth in Cities," Scholarly Articles 3451309, Harvard University Department of Economics.
    4. Philip Cooke, 2005. "Rational drug design, the knowledge value chain and bioscience megacentres," Cambridge Journal of Economics, Cambridge Political Economy Society, vol. 29(3), pages 325-341, May.
    5. Cooke, Phil, 2005. "Regionally asymmetric knowledge capabilities and open innovation: Exploring 'Globalisation 2'--A new model of industry organisation," Research Policy, Elsevier, vol. 34(8), pages 1128-1149, October.
    6. Philip Cooke, 2004. "The Molecular Biology Revolution and the Rise of Bioscience Megacentres in North America and Europe," Environment and Planning C, , vol. 22(2), pages 161-177, April.
    7. Ron Boschma, 2005. "Proximity and Innovation: A Critical Assessment," Regional Studies, Taylor & Francis Journals, vol. 39(1), pages 61-74.
    8. Steven Klepper, 2002. "The capabilities of new firms and the evolution of the US automobile industry," Industrial and Corporate Change, Oxford University Press and the Associazione ICC, vol. 11(4), pages 645-666, August.
    9. Jason Owen-Smith & Walter W. Powell, 2004. "Knowledge Networks as Channels and Conduits: The Effects of Spillovers in the Boston Biotechnology Community," Organization Science, INFORMS, vol. 15(1), pages 5-21, February.
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    1. ., 2011. "Introduction to the Handbook of Regional Innovation and Growth," Chapters, in: Philip Cooke & Bjørn Asheim & Ron Boschma & Ron Martin & Dafna Schwartz & Franz Tödtling (ed.), Handbook of Regional Innovation and Growth, chapter 1, Edward Elgar Publishing.
    2. Stefan Hennemann & Diego Rybski & Ingo Liefner, 2011. "The Myth of Global Science," ERSA conference papers ersa10p246, European Regional Science Association.
    3. Markus M. Bugge & Teis Hansen & Antje Klitkou, 2016. "What Is the Bioeconomy? A Review of the Literature," Sustainability, MDPI, vol. 8(7), pages 1-22, July.
    4. Sylvie Benoit, 2022. "Industrial anchorage in bioeconomy: what role does logistics governance play? [Ancrage industriel en bioéconomie : quel rôle joue la gouvernance logistique ?]," Post-Print hal-03984202, HAL.

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