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Spectrotemporal Response Properties of Core Auditory Cortex Neurons in Awake Monkey

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  • Roohollah Massoudi
  • Marc M Van Wanrooij
  • Huib Versnel
  • A John Van Opstal

Abstract

So far, most studies of core auditory cortex (AC) have characterized the spectral and temporal tuning properties of cells in non-awake, anesthetized preparations. As experiments in awake animals are scarce, we here used dynamic spectral-temporal broadband ripples to study the properties of the spectrotemporal receptive fields (STRFs) of AC cells in awake monkeys. We show that AC neurons were typically most sensitive to low ripple densities (spectral) and low velocities (temporal), and that most cells were not selective for a particular spectrotemporal sweep direction. A substantial proportion of neurons preferred amplitude-modulated sounds (at zero ripple density) to dynamic ripples (at non-zero densities). The vast majority (>93%) of modulation transfer functions were separable with respect to spectral and temporal modulations, indicating that time and spectrum are independently processed in AC neurons. We also analyzed the linear predictability of AC responses to natural vocalizations on the basis of the STRF. We discuss our findings in the light of results obtained from the monkey midbrain inferior colliculus by comparing the spectrotemporal tuning properties and linear predictability of these two important auditory stages.

Suggested Citation

  • Roohollah Massoudi & Marc M Van Wanrooij & Huib Versnel & A John Van Opstal, 2015. "Spectrotemporal Response Properties of Core Auditory Cortex Neurons in Awake Monkey," PLOS ONE, Public Library of Science, vol. 10(2), pages 1-30, February.
    • Handle: RePEc:plo:pone00:0116118
    DOI: 10.1371/journal.pone.0116118
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    References listed on IDEAS

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    1. Craig A Atencio & Christoph E Schreiner, 2012. "Spectrotemporal Processing in Spectral Tuning Modules of Cat Primary Auditory Cortex," PLOS ONE, Public Library of Science, vol. 7(2), pages 1-15, February.
    2. Xiaoqin Wang & Thomas Lu & Ross K. Snider & Li Liang, 2005. "Sustained firing in auditory cortex evoked by preferred stimuli," Nature, Nature, vol. 435(7040), pages 341-346, May.
    3. Jan W. H. Schnupp & Thomas D. Mrsic-Flogel & Andrew J. King, 2001. "Linear processing of spatial cues in primary auditory cortex," Nature, Nature, vol. 414(6860), pages 200-204, November.
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    Cited by:

    1. Ivar L Thorson & Jean Liénard & Stephen V David, 2015. "The Essential Complexity of Auditory Receptive Fields," PLOS Computational Biology, Public Library of Science, vol. 11(12), pages 1-33, December.

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