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The Neuronal Responses to Repetitive Acoustic Pulses in Different Fields of the Auditory Cortex of Awake Rats

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  • Lanlan Ma
  • Xuhui Tai
  • Liye Su
  • Lijuan Shi
  • Enhua Wang
  • Ling Qin

Abstract

Cortical representation of time-varying features of acoustic signals is a fundamental issue of acoustic processing remaining unresolved. The rat is a widely used animal model for auditory cortical processing. Though some electrophysiological studies have investigated the neural responses to temporal repetitive sounds in the auditory cortex (AC) of rats, most of them were conducted under anesthetized condition. Recently, it has been shown that anesthesia could significantly alter the temporal patterns of neural response. For this reason, we systematically examined the single-unit neural responses to click-trains in the core region of rat AC under awake condition. Consistent with the reports on anesthetized rats, we confirmed the existence of characteristic tonotopic organizations, which were used to divide the AC into anterior auditory field (AAF), primary auditory cortex (A1) and posterior auditory field (PAF). We further found that the neuron's capability to synchronize to the temporal repetitive stimuli progressively decreased along the anterior-to-posterior direction of AC. The median of maximum synchronization rate was 64, 32 and 16 Hz in AAF, A1 and PAF, respectively. On the other hand, the percentage of neurons, which showed non-synchronized responses and could represent the stimulus repetition rate by the mean firing rate, increased from 7% in AAF and A1 to 20% in PAF. These results suggest that the temporal resolution of acoustic processing gradually increases from the anterior to posterior part of AC, and thus there may be a hierarchical stream along this direction of rat AC.

Suggested Citation

  • Lanlan Ma & Xuhui Tai & Liye Su & Lijuan Shi & Enhua Wang & Ling Qin, 2013. "The Neuronal Responses to Repetitive Acoustic Pulses in Different Fields of the Auditory Cortex of Awake Rats," PLOS ONE, Public Library of Science, vol. 8(5), pages 1-10, May.
    • Handle: RePEc:plo:pone00:0064288
    DOI: 10.1371/journal.pone.0064288
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    References listed on IDEAS

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    1. Xiaoqin Wang & Thomas Lu & Ross K. Snider & Li Liang, 2005. "Sustained firing in auditory cortex evoked by preferred stimuli," Nature, Nature, vol. 435(7040), pages 341-346, May.
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    Cited by:

    1. Daniel Bendor, 2015. "The Role of Inhibition in a Computational Model of an Auditory Cortical Neuron during the Encoding of Temporal Information," PLOS Computational Biology, Public Library of Science, vol. 11(4), pages 1-25, April.

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