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The Association of Sport Performance with ACE and ACTN3 Genetic Polymorphisms: A Systematic Review and Meta-Analysis

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  • Fang Ma
  • Yu Yang
  • Xiangwei Li
  • Feng Zhou
  • Cong Gao
  • Mufei Li
  • Lei Gao

Abstract

Background: Genetic polymorphism is suggested to be associated with human physical performance. The angiotensin I-converting enzyme insertion/deletion (ACE I/D) polymorphism and the α-actinin-3 gene (ACTN3) R577X polymorphism have been most widely studied for such association analysis. However, the findings are frequently heterogeneous. We aim to summarize the associations of ACE I/D and ACTN3 R577X with sport performance by means of meta-analysis. Methods: We systematically reviewed and quantitatively summarized published studies, until October 31, 2012, on relationship between ACE/ACTN3 genetic polymorphisms and sports performance, respectively. Results: A total of 366 articles on ACE and 88 articles on ACTN3 were achieved by literature search. A significant association was found for ACE II genotype compared to D allele carriage (DD+ID) with increased possibility of physical performance (OR, 1.23; 95% CI, 1.05–1.45). With respect to sport discipline, the II genotype was found to be associated with performance in endurance athletes (OR, 1.35; 95% CI, 1.17–1.55). On the other hand, no significant association was observed for ACTN3 RR genotype as compared to X allele carriage (XX+RX) (OR, 1.03; 95% CI, 0.92–1.15). However, when restricted the analyses to power events, a significant association was observed (OR, 1.21; 95% CI, 1.03–1.42). Conclusion: Our results provide more solid evidence for the associations between ACE II genotype and endurance events and between ACTN3 R allele and power events. The findings suggest that the genetic profiles might influence human physical performance.

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  • Fang Ma & Yu Yang & Xiangwei Li & Feng Zhou & Cong Gao & Mufei Li & Lei Gao, 2013. "The Association of Sport Performance with ACE and ACTN3 Genetic Polymorphisms: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(1), pages 1-9, January.
    • Handle: RePEc:plo:pone00:0054685
    DOI: 10.1371/journal.pone.0054685
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    References listed on IDEAS

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    1. XiangWei Li & Yu Yang & Feng Zhou & Yunzhi Zhang & Hongzhou Lu & Qi Jin & Lei Gao, 2011. "SLC11A1 (NRAMP1) Polymorphisms and Tuberculosis Susceptibility: Updated Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 6(1), pages 1-8, January.
    2. A. G. Williams & M. P. Rayson & M. Jubb & M. World & D. R. Woods & M. Hayward & J. Martin & S. E. Humphries & H. E. Montgomery, 2000. "The ACE gene and muscle performance," Nature, Nature, vol. 403(6770), pages 614-614, February.
    3. H. E. Montgomery & R. Marshall & H. Hemingway & S. Myerson & P. Clarkson & C. Dollery & M. Hayward & D. E. Holliman & M. Jubb & M. World & E. L. Thomas & A. E. Brynes & N. Saeed & M. Barnard & J. D. B, 1998. "Human gene for physical performance," Nature, Nature, vol. 393(6682), pages 221-222, May.
    4. Yu Yang & Xiangwei Li & Feng Zhou & Qi Jin & Lei Gao, 2011. "Prevalence of Drug-Resistant Tuberculosis in Mainland China: Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 6(6), pages 1-7, June.
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    Cited by:

    1. Phuntila Tharabenjasin & Noel Pabalan & Hamdi Jarjanazi, 2019. "Association of the ACTN3 R577X (rs1815739) polymorphism with elite power sports: A meta-analysis," PLOS ONE, Public Library of Science, vol. 14(5), pages 1-20, May.
    2. Cristina Romero-Blanco & María Jesús Artiga-González & Alba Gómez-Cabello & Sara Vila-Maldonado & José Antonio Casajús & Ignacio Ara & Susana Aznar, 2020. "Strength and Endurance Training in Older Women in Relation to ACTN3 R577X and ACE I/D Polymorphisms," IJERPH, MDPI, vol. 17(4), pages 1-10, February.
    3. Craig Pickering & John Kiely, 2017. "Understanding Personalized Training Responses: Can Genetic Assessment Help?," The Open Sports Sciences Journal, Bentham Open, vol. 10(1), pages 191-213, November.
    4. Omar Peña-Vázquez & Liliana Aracely Enriquez-del Castillo & Susana Aideé González-Chávez & Jaime Güereca-Arvizuo & Ramon Candia Lujan & Claudia Esther Carrasco Legleu & Natanael Cervantes Hernández & , 2023. "Prevalence of Polymorphism and Post-Training Expression of ACTN3 (R/X) and ACE (I/D) Genes in CrossFit Athletes," IJERPH, MDPI, vol. 20(5), pages 1-13, March.

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