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A Meta-Analysis of P2X7 Gene-762T/C Polymorphism and Pulmonary Tuberculosis Susceptibility

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  • Lingling Yi
  • Dan Cheng
  • Huimin Shi
  • Xiaorong Huo
  • Kan Zhang
  • Guohua Zhen

Abstract

Aim: We performed a comprehensive meta-analysis to determine the association between P2X7 -762T/C polymorphism and pulmonary tuberculosis susceptibility. Methodology: Based on comprehensive searches of the PubMed, SCI, Elsevier, China National Knowledge Infrastructure (CNKI) and Wanfang Database, we identified eligible studies about the association between P2X7 -762T/C polymorphism and pulmonary tuberculosis risk. Pooled odds ratio (ORs) and 95% confidence intervals (95%CIs) were calculated in random-effects model. Results: A total of 2207 tuberculosis cases and 2220 controls in 8 case-control studies were included in this meta-analysis. Allele model (C vs. T: p = 0.15; OR = 0.83, 95% CI = 0.65–1.07), homozygous model (CC vs. TT: p = 0.23; OR = 0.73, 95% CI = 0.44 to 1.22), and heterozygous model (CT vs. TT: p = 0.57; OR = 0.92, 95% CI = 0.68 to 1.24) did not show increased risk of developing pulmonary tuberculosis. Similarly, dominant model (CC+CT vs. TT: p = 0.32; OR = 0.84, 95% CI = 0.59 to 1.19) and recessive model (CC vs. CT+TT: p = 0.08; OR = 0.77, 95% CI = 0.57 to 1.04) failed to show increased risk of developing pulmonary tuberculosis. Subgroup analysis by ethnicity did not detect any significant association between P2X7–762T/C polymorphism and pulmonary tuberculosis susceptibility. Conclusions: P2X7 -762T/C gene polymorphism is not associated with pulmonary tuberculosis susceptibility.

Suggested Citation

  • Lingling Yi & Dan Cheng & Huimin Shi & Xiaorong Huo & Kan Zhang & Guohua Zhen, 2014. "A Meta-Analysis of P2X7 Gene-762T/C Polymorphism and Pulmonary Tuberculosis Susceptibility," PLOS ONE, Public Library of Science, vol. 9(5), pages 1-7, May.
    • Handle: RePEc:plo:pone00:0096359
    DOI: 10.1371/journal.pone.0096359
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    References listed on IDEAS

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    1. XiangWei Li & Yu Yang & Feng Zhou & Yunzhi Zhang & Hongzhou Lu & Qi Jin & Lei Gao, 2011. "SLC11A1 (NRAMP1) Polymorphisms and Tuberculosis Susceptibility: Updated Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 6(1), pages 1-8, January.
    2. Yu-jiao Wu & Xin Yang & Xiao-xiao Wang & Man-Tang Qiu & Yi-zhong You & Zhi-xin Zhang & Shan-mei Zhu & Lin Xu & Feng-lei Tang, 2013. "Association of Vitamin D Receptor BsmI Gene Polymorphism with Risk of Tuberculosis: A Meta-Analysis of 15 Studies," PLOS ONE, Public Library of Science, vol. 8(6), pages 1-8, June.
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