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Association of the ACTN3 R577X (rs1815739) polymorphism with elite power sports: A meta-analysis

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  • Phuntila Tharabenjasin
  • Noel Pabalan
  • Hamdi Jarjanazi

Abstract

Objective: The special status accorded to elite athletes stems from their uncommon genetic potential to excel in world-class power sports (PS). Genetic polymorphisms have been reported to influence elite PS status. Reports of associations between the α-actinin-3 gene (ACTN3) R577X polymorphism and PS have been inconsistent. In light of new published studies, we perform a meta-analysis to further explore the roles of this polymorphism in PS performance among elite athletes. Methods: Multi-database literature search yielded 44 studies from 38 articles. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were used in estimating associations (significance threshold was set at Pa ≤ 0.05) using the allele-genotype model (R and X alleles, RX genotype). Outlier analysis was used to examine its impact on association and heterogeneity outcomes. Subgroup analysis was race (Western and Asian) and gender (male/female)-based. Interaction tests were applied to differential outcomes between the subgroups, P-values of which were Bonferroni corrected (Pinteraction BC). Tests for sensitivity and publication bias were performed. Results: Significant overall R allele effects (OR 1.21, 95% CI 1.07–1.37, Pa = 0.002) were confirmed in the Western subgroup (OR 1.11, 95% CI 1.01–1.22, Pa = 0.02) and with outlier treatment (ORs 1.12–1.20, 95% CIs 1.02–1.30, Pa

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  • Phuntila Tharabenjasin & Noel Pabalan & Hamdi Jarjanazi, 2019. "Association of the ACTN3 R577X (rs1815739) polymorphism with elite power sports: A meta-analysis," PLOS ONE, Public Library of Science, vol. 14(5), pages 1-20, May.
    • Handle: RePEc:plo:pone00:0217390
    DOI: 10.1371/journal.pone.0217390
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    References listed on IDEAS

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    1. Fang Ma & Yu Yang & Xiangwei Li & Feng Zhou & Cong Gao & Mufei Li & Lei Gao, 2013. "The Association of Sport Performance with ACE and ACTN3 Genetic Polymorphisms: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(1), pages 1-9, January.
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    1. Arben Boshnjaku & Ermira Krasniqi & Harald Tschan & Barbara Wessner, 2021. "ACTN3 Genotypes and Their Relationship with Muscle Mass and Function of Kosovan Adults," IJERPH, MDPI, vol. 18(17), pages 1-13, August.

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