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The Prevalence of Drug-Resistant Tuberculosis in Mainland China: An Updated Systematic Review and Meta-Analysis

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  • Qionghong Duan
  • Zi Chen
  • Cong Chen
  • Zhengbin Zhang
  • Zhouqin Lu
  • Yalong Yang
  • Lin Zhang

Abstract

Background: In recent years, drug resistant tuberculosis (DR-TB) particularly the emergence of multi-drug-resistant tuberculosis (MDR-TB) has become a major public health issue. The most recent study regarding the prevalence of drug-resistant tuberculosis in mainland China was a meta-analysis published in 2011, and the subjects from the included studies were mostly enrolled before 2008, thus making it now obsolete. Current data on the national prevalence of DR-TB is needed. This review aims to provide a comprehensive and up-to-date assessment of the status of DR-TB epidemic in mainland China. Methods: A systematic review and meta-analysis of studies regarding the prevalence of drug-resistant tuberculosis in mainland China was performed. Pubmed/MEDLINE, EMBASE, the Cochrane central database, the Chinese Biomedical Literature Database and the China National Knowledge Infrastructure Database were searched for studies relevant to drug-resistant tuberculosis that were published between January 1, 2012 and May 18, 2015. Comprehensive Meta-Analysis (V2.2, Biostat) software was used to analyse the data. Results: A total of fifty-nine articles, published from 2012 to 2015, were included in our review. The result of this meta-analysis demonstrated that among new cases, the rate of resistance to any drug was 20.1% (18.0%–22.3%; n/N = 7203/34314) and among retreatment cases, the rate was 49.8% (46.0%–53.6%; n/N = 4155/8291). Multi-drug resistance among new and retreatment cases was 4.8% (4.0%–5.7%; n/N = 2300/42946) and 26.3% (23.1%–29.7%; n/N = 3125/11589) respectively. The results were significantly heterogeneous (p

Suggested Citation

  • Qionghong Duan & Zi Chen & Cong Chen & Zhengbin Zhang & Zhouqin Lu & Yalong Yang & Lin Zhang, 2016. "The Prevalence of Drug-Resistant Tuberculosis in Mainland China: An Updated Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(2), pages 1-11, February.
    • Handle: RePEc:plo:pone00:0148041
    DOI: 10.1371/journal.pone.0148041
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    References listed on IDEAS

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    1. Mohammad Javad Nasiri & Hossein Dabiri & Davood Darban-Sarokhalil & Abdolrazagh Hashemi Shahraki, 2015. "Prevalence of Non-Tuberculosis Mycobacterial Infections among Tuberculosis Suspects in Iran: Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(6), pages 1-9, June.
    2. Yu Yang & Xiangwei Li & Feng Zhou & Qi Jin & Lei Gao, 2011. "Prevalence of Drug-Resistant Tuberculosis in Mainland China: Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 6(6), pages 1-7, June.
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    1. Cajetan C Onyedum & Isaac Alobu & Kingsley Nnanna Ukwaja, 2017. "Prevalence of drug-resistant tuberculosis in Nigeria: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 12(7), pages 1-17, July.

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