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SLC11A1 (NRAMP1) Polymorphisms and Tuberculosis Susceptibility: Updated Systematic Review and Meta-Analysis

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  • XiangWei Li
  • Yu Yang
  • Feng Zhou
  • Yunzhi Zhang
  • Hongzhou Lu
  • Qi Jin
  • Lei Gao

Abstract

Background: Natural resistance associated macrophage protein 1 (NRAMP1), encoded by the SLC11A1 gene, has been described to regulate macrophage activation and be associated with infectious and autoimmune diseases. The relation between SLC11A1 polymorphisms and tuberculosis susceptibility has been studied in different populations. Methods: We systematically reviewed published studies on SLC11A1 polymorphisms and tuberculosis susceptibility until September 15, 2010 and quantitatively summarized associations of the most widely studied polymorphisms using meta-analysis. Results: In total, 36 eligible articles were included in this review. In Meta-analysis, significant associations were observed between tuberculosis risk and widely studied SLC11A1 polymorphisms with summarized odds ratio of 1.35 (95%CI, 1.17–1.54), 1.25 (95% CI, 1.04–1.50), 1.23 (95% CI, 1.04–1.44), 1.31 (95%CI, 1.08–1.59) for 3′ UTR, D543N, INT4, and 5′ (GT)n, respectively. Heterogeneity between studies was not pronounced, and the associations did not remarkably vary in the stratified analysis with respect to study population and study base. Conclusions: The association between SLC11A1 polymorphisms and tuberculosis susceptibility observed in our analyses supports the hypothesis that NRAMP1 might play an important role in the host defense to the development of tuberculosis.

Suggested Citation

  • XiangWei Li & Yu Yang & Feng Zhou & Yunzhi Zhang & Hongzhou Lu & Qi Jin & Lei Gao, 2011. "SLC11A1 (NRAMP1) Polymorphisms and Tuberculosis Susceptibility: Updated Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 6(1), pages 1-8, January.
    • Handle: RePEc:plo:pone00:0015831
    DOI: 10.1371/journal.pone.0015831
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    Cited by:

    1. Fang Ma & Yu Yang & Xiangwei Li & Feng Zhou & Cong Gao & Mufei Li & Lei Gao, 2013. "The Association of Sport Performance with ACE and ACTN3 Genetic Polymorphisms: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(1), pages 1-9, January.
    2. Lingling Yi & Dan Cheng & Huimin Shi & Xiaorong Huo & Kan Zhang & Guohua Zhen, 2014. "A Meta-Analysis of P2X7 Gene-762T/C Polymorphism and Pulmonary Tuberculosis Susceptibility," PLOS ONE, Public Library of Science, vol. 9(5), pages 1-7, May.
    3. Bonnie N Young & Adrian Rendón & Adrian Rosas-Taraco & Jack Baker & Meghan Healy & Jessica M Gross & Jeffrey Long & Marcos Burgos & Keith L Hunley, 2014. "The Effects of Socioeconomic Status, Clinical Factors, and Genetic Ancestry on Pulmonary Tuberculosis Disease in Northeastern Mexico," PLOS ONE, Public Library of Science, vol. 9(4), pages 1-8, April.
    4. Obeagu Emmanuel Ifeanyi, 2018. "A Review on Iron Homeostasis and Anaemia in Pulmonary Tuberculosis," International Journal of Healthcare and Medical Sciences, Academic Research Publishing Group, vol. 4(5), pages 84-89, 05-2018.
    5. Kai Chang & Shaoli Deng & Weiping Lu & Feng Wang & Shuangrong Jia & Fake Li & Lili Yu & Ming Chen, 2012. "Association between CD209 -336A/G and -871A/G Polymorphisms and Susceptibility of Tuberculosis: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(7), pages 1-9, July.

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