IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v403y2000i6770d10.1038_35001141.html
   My bibliography  Save this article

The ACE gene and muscle performance

Author

Listed:
  • A. G. Williams

    (Optimal Performance)

  • M. P. Rayson

    (Optimal Performance)

  • M. Jubb

    (Royal Defence Medical College, HMS Dolphin)

  • M. World

    (Royal Defence Medical College, HMS Dolphin)

  • D. R. Woods

    (British Heart Foundation, Centre for Cardiovascular Genetics, RFUCLMS, Rayne Institute)

  • M. Hayward

    (British Heart Foundation, Centre for Cardiovascular Genetics, RFUCLMS, Rayne Institute)

  • J. Martin

    (British Heart Foundation, Centre for Cardiovascular Genetics, RFUCLMS, Rayne Institute)

  • S. E. Humphries

    (British Heart Foundation, Centre for Cardiovascular Genetics, RFUCLMS, Rayne Institute)

  • H. E. Montgomery

    (British Heart Foundation, Centre for Cardiovascular Genetics, RFUCLMS, Rayne Institute)

Abstract

Angiotensin-converting enzyme in human skeletal muscle1 can be encoded by either of two variants of the ACE gene2, one of which carries an insertion of 287 base pairs. This longer allele gives rise to lower enzyme activity2, and is associated with enhanced endurance performance3 and an anabolic response to intense exercise training4. Here we examine training-related changes in the mechanical efficiency of human skeletal muscle (energy used per unit power output) and find that the presence of this ACE allele confers an enhanced mechanical efficiency in trained muscle.

Suggested Citation

  • A. G. Williams & M. P. Rayson & M. Jubb & M. World & D. R. Woods & M. Hayward & J. Martin & S. E. Humphries & H. E. Montgomery, 2000. "The ACE gene and muscle performance," Nature, Nature, vol. 403(6770), pages 614-614, February.
    • Handle: RePEc:nat:nature:v:403:y:2000:i:6770:d:10.1038_35001141
    DOI: 10.1038/35001141
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/35001141
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/35001141?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Mark M Pitt & Mark R Rosenzweig & M Nazmul Hassan, 2021. "Identifying the Costs of a Public Health Success: Arsenic Well Water Contamination and Productivity in Bangladesh [Individual Variations in Inorganic Arsenic Metabolism Associated with AS3MT Geneti," The Review of Economic Studies, Review of Economic Studies Ltd, vol. 88(5), pages 2479-2526.
    2. Lydia Sommers & Liz Akam & David John Hunter & Jasvinder Singh Bhatti & Sarabjit Mastana, 2024. "Role of the ACE I/D Polymorphism in Selected Public Health-Associated Sporting Modalities: An Updated Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 21(11), pages 1-18, October.
    3. Fang Ma & Yu Yang & Xiangwei Li & Feng Zhou & Cong Gao & Mufei Li & Lei Gao, 2013. "The Association of Sport Performance with ACE and ACTN3 Genetic Polymorphisms: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(1), pages 1-9, January.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:403:y:2000:i:6770:d:10.1038_35001141. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.